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  1. Computational discovery of transcription factors associated with drug responseRead the original story

    Oct 27, 2015 | The Pharmacogenomics Journal

    Correspondence: Dr L Wang, Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, Gonda 19, Mayo Clinic Rochester, 200, 1st Street SW, Rochester, MN 55905, USAE-mail: [email protected] ; Dr S Sinha, Department of Computer Science and Institute of Genomic Biology, University of Illinois at Urbana–Champaign, 201 North Goodwin Avenue, Urbana, IL 61801, USA. E-mail: [email protected] This study integrates gene expression, genotype and drug response data in lymphoblastoid cell lines with transcription factor -binding sites from ENCODE in a novel methodology that elucidates regulatory contexts associated with cytotoxicity.

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