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Address correspondence to Sven Kroener, School of Behavioral and Brain Sciences, The University of Texas at Dallas, 800 West Campbell Rd, GR41, Richardson, TX 75080, USA. Email: The N -methyl-D-aspartic acid -hypofunction theory of schizophrenia suggests that schizophrenia is associated with a loss of NMDA receptors, specifically on corticolimbic parvalbumin -expressing GABAergic interneurons, leading to disinhibition of pyramidal cells and cortical desynchronization. Comment?
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