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  1. New ultrasound scoring system for thyroid nodules to reduce unnecessary biopsiesRead the original story w/Photo

    Sunday Jun 18 | PhysOrg Weblog

    Nodules-a type of abnormality detected by ultrasound-are extremely common in the thyroid gland. Up to two-thirds of adults have nodules in this gland, and most are benign or only cause a slow-growing cancer that is no threat to life.

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  2. Small unruptured intracranial aneurysms grow slowlyRead the original story w/Photo

    Tuesday Jun 6 | PhysOrg Weblog

    Small unruptured intracranial aneurysms have low growth and rupture rates, according to a review published online June 6 in the Annals of Internal Medicine . Ajay Malhotra, M.D., from the Yale School of Medicine and Yale University in New Haven, Conn., and colleagues conducted a systematic literature review and summarized evidence relating to the growth and rupture risk of UIAs 7 mm and smaller and rupture risks for very-small and small aneurysms .

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  3. Mutations in SULT2B1 tied to ichthyosis in humansRead the original story w/Photo

    Monday Jun 5 | PhysOrg Weblog

    Scientists have discovered another gene mutation behind certain cases of autosomal-recessive congenital ichthyosis , according to a report published in the June 1 issue of the American Journal of Human Genetics . Keith Choate, M.D., Ph.D., of the Yale University School of Medicine in New Haven, Conn., and colleagues utilized whole-exome sequencing and multigene panel screening to identify four distinct mutations in ARCI, including missense, nonsense, and splice site mutations.

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  4. Hypothalamic Lin28a shows role in glucose homeostasisRead the original story w/Photo

    Monday Jun 5 | PhysOrg Weblog

    The study was published online May 26 in Diabetes . Jung Dae Kim, Ph.D., from the Yale University School of Medicine in New Haven, Conn., and colleagues examined the central function of the Lin28a/ Let-7 axis.

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  5. Lower-, higher-dose elagolix beneficial for endometriosisRead the original story w/Photo

    May 22, 2017 | PhysOrg Weblog

    Lower- and higher-dose elagolix are beneficial for women with endometriosis, according to research published online May 19 in the New England Journal of Medicine to coincide with the 13th World Congress on Endometriosis, held from May 17 to 20 in Vancouver, Canada. Hugh S. Taylor, M.D., from the Yale School of Medicine in New Haven, Conn., and colleagues conducted two phase 3 trials to examine the impact of lower-dose and higher-dose elagolix versus placebo for women with surgically diagnosed endometriosis and moderate or severe endometriosis-associated pain .

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  6. Safety events common for pharmaceuticals and biologics after FDA approvalRead the original story w/Photo

    May 9, 2017 | PhysOrg Weblog

    Among more than 200 new pharmaceuticals and biologics approved by the U.S. Food and Drug Administration from 2001 through 2010, nearly a third were affected by a postmarket safety event such as issuance of a boxed warning or safety communication, according to a study published by JAMA . The majority of pivotal trials that form the basis for FDA approval for therapeutics enroll fewer than 1,000 patients with follow-up of six months or less, which may make it challenging to identify uncommon or long-term serious safety risks.

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  7. Care transitions common at end of life for medicare recipientsRead the original story w/Photo

    Apr 12, 2017 | PhysOrg Weblog

    More than one-third of Medicare beneficiaries who died in 2011 had at least four care transitions during their last six months of life, according to a study published online April 3 in the Journal of the American Geriatrics Society . Shi-Yi Wang, M.D., Ph.D., from Yale University in New Haven, Conn., and colleagues evaluated transitions between health care settings in the last six months of life among Medicare beneficiaries aged 66 and older who died between July and December 2011.

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  8. Nurse! what's taking so long?Read the original story w/Photo

    Apr 11, 2017 | PhysOrg Weblog

    Researchers found that nurses are usually quick to react when alarms are urgent. But, they're slower to respond at the end of the workday or when they suffer from "chronic alarm fatigue."

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  9. Threat of firearm use affects PTSD symptoms among female victims of partner violenceRead the original story w/Photo

    Apr 10, 2017 | PhysOrg Weblog

    A new study shows that the threat of firearm use by a male partner in an intimate relationship is a significant predictor of post-traumatic stress disorder symptom severity in women, independent of other forms of interpersonal partner violence. The study is published in Violence and Gender .

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  10. PROTAC shows efficacy against castration-resistant prostate cancer in preclinical studiesRead the original story w/Photo

    Apr 5, 2017 | PhysOrg Weblog

    An orally bioavailable androgen receptor PROTAC, developed using a protein degradation technology, was effective in lowering tumor burden in mice bearing human castration-resistant prostate cancer, according to data presented here at the AACR Annual Meeting 2017, April 1-5. "More than 15 years ago, Professor Craig Crews of Yale University had an idea of targeting oncoproteins for degradation by essentially hijacking the endogenous ubiquitination and proteasome machinery.

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  11. Tanning's allure tied to other addictionsRead the original story w/Photo

    Mar 31, 2017 | PhysOrg Weblog

    People who seem to have a deep tan year-round-whether from the sun or indoor tanning-may be "addicted" to tanning. And new research suggests there's also a link between such tanning and other addictions.

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  12. Updated appropriate use criteria address coronary revascularization for patients with SIHDRead the original story w/Photo

    Mar 10, 2017 | PhysOrg Weblog

    The American College of Cardiology, along with several partnering organizations, today released updated appropriate use criteria for performing coronary revascularization in patients with stable ischemic heart disease. In ischemic heart disease , clogged arteries cause the heart muscle to be deprived of the oxygen-rich blood needed to function.

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  13. Antidepressant efficacy varies for depressive symptom clustersRead the original story w/Photo

    Feb 28, 2017 | PhysOrg Weblog

    Antidepressant treatment efficacy varies for empirically-defined clusters of symptoms, according to a study published online Feb. 22 in JAMA Psychiatry . Adam M. Chekroud, from Yale University in New Haven, Conn., and colleagues determined the efficacy of antidepressant treatments on empirically defined groups of symptoms .

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  14. 1 in 4 teen E-cigarette users has tried 'Dripping'Read the original story w/Photo

    Feb 6, 2017 | PhysOrg Weblog

    One-quarter of U.S. teen e-cigarette users have experimented with "dripping"-a new vaping method that produces thicker clouds of vapor, researchers report. Regular electronic cigarettes produce inhalable vapor by gradually drawing liquid into a heating coil through an automatic wick, explained lead researcher Suchitra Krishnan-Sarin.

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  15. Evaluation of recombinant antithrombin versus placebo in preterm preeclampsiaRead the original story w/Photo

    Jan 23, 2017 | PhysOrg Weblog

    In a study to be presented Friday, Jan. 27, in the late breaking oral session, at the Society for Maternal-Fetal Medicine's annual meeting, The Pregnancy Meeting, researchers with The PRESERVE-1 Study Group University of Texas Health Science Center at Houston-McGovern Medical School, Houston, Texas, and Yale School of Medicine, New Haven, Connecticut, present findings of a study titled Randomized double-blind placebo controlled evaluation of the safety and efficacy of recombinant Antithrombin versus placebo in preterm preeclampsia. The study was sponsored by rEVO Biologics, Inc. Preeclampsia is a major cause of maternal and perinatal mortality and morbidity.

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  16. Gun violence may be 'contagious,' study suggestsRead the original story w/Photo

    Jan 3, 2017 | PhysOrg Weblog

    To predict someone's risk of becoming a victim of gun violence, a new study offers a suggestion: Look at the company they keep. Researchers report that gun violence may actually be "contagious," with social networks acting as a breeding ground for the spread of gun exposure and violence.

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  17. JAMA Internal Medicine publishes more articles on firearm violenceRead the original story w/Photo

    Jan 3, 2017 | PhysOrg Weblog

    JAMA Internal Medicine is publishing another collection of articles on firearm violence, including two original investigations, two commentaries and an editorial. JAMA also is publishing a research letter on gun violence research.

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  18. New appropriate use criteria for coronary revascularization releasedRead the original story w/Photo

    Dec 21, 2016 | PhysOrg Weblog

    The American College of Cardiology, along with several partnering organizations, today released updated appropriate use criteria for performing coronary revascularization in patients with acute coronary syndromes. Patients with acute coronary syndromes suffer from sudden, reduced blood flow to the heart, requiring quick diagnosis and care.

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  19. Daily low-dose aspirin may cut pancreatic cancer riskRead the original story w/Photo

    Dec 20, 2016 | PhysOrg Weblog

    There's evidence that daily low-dose aspirin may decrease the risk of pancreatic cancer, according to a new study. The Chinese-based study couldn't prove cause-and-effect.

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  20. Cancer genomics continued: Triple negative breast cancer and cancer immunotherapyRead the original story w/Photo

    Dec 13, 2016 | PhysOrg Weblog

    Continuing PLOS Medicine 's special issue on cancer genomics, Christos Hatzis of Yale University, New Haven, CT, USA and colleagues describe a new subtype of triple negative breast cancer that may be more amenable to treatment than other cases of this difficult-to-treat disease. Triple negative breast cancer is so called because it lacks molecular characteristics that are associated with response to modern targeted treatments.

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