Cold Spring Harbor Newswire

Cold Spring Harbor Newswire

Comprehensive Real-Time News Feed for Cold Spring Harbor, NY.

Results 1 - 11 of 11 for "u:newswise.com" in Cold Spring Harbor, NY

  1. Research Suggests a Possible Role for a Storm of "Jumping Genes" in ALSRead the original story

    Friday Mar 24 | Newswise

    Stony Brook, NY - March 24, 2017 - By inserting an amyotrophic lateral sclerosis -linked human gene called TDP-43 into fruit flies, researchers at Stony Brook University and Cold Spring Harbor Laboratory discovered a potential role for 'transposons' in the disease. Transposons, which are also called 'jumping genes' because they jump from place to place within DNA, are virus-like entities that fill most of the spaces between genes in an organism.

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  2. Some Genetic Variations May Be Particularly Difficult to Evaluate...Read the original story

    Monday Mar 13 | Newswise

    Some heritable but unstable genetic mutations that are passed from parent to affected offspring may not be easy to investigate using current human-induced pluripotent stem cell modeling techniques, according to research conducted at The Icahn School of Medicine at Mount Sinai and published March 14, in the journal Stem Cell Reports. The study serves to caution stem cell biologists that certain rare mutations, like the ones described in the study, are difficult to recreate in laboratory-produced stem cells.

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  3. ORC as Loader of the RingsRead the original story

    Feb 21, 2017 | Newswise

    An international collaboration of life scientists, including experts at Van Andel Research Institute , has described in exquisite detail the critical first steps of DNA replication, which allows cells to divide and most advanced life, including human, to propagate. Results of the study are published in the journal Nature Structural and Molecular Biology and reveal that a ring-shaped protein called origin recognition complex possesses a special alpha-helix, which slips into a groove on DNA and initiates a cascade of microscopic interactions that copy DNA.

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  4. Researchers Identify 'Achilles' Heel' of PTEN That Helps Drive Prostate Cancer ProgressionRead the original story

    Feb 13, 2017 | Newswise

    Cold Spring Harbor, NY -- Researchers at Cold Spring Harbor Laboratory have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it into the cell nucleus. A study they publish today in The Journal of Cell Biology suggests that the loss of Importin-11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers.

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  5. Researchers Identify "Achilles' Heel" of Key Anti-Cancer ProteinRead the original story

    Feb 13, 2017 | Newswise

    Researchers at Cold Spring Harbor Laboratory in New York have discovered that a protein called Importin-11 protects the anti-cancer protein PTEN from destruction by transporting it into the cell nucleus. The study, " The nuclear transport receptor Importin-11 is a tumor suppressor that maintains PTEN protein ," which will be published online February 13 in The Journal of Cell Biology, suggests that the loss of Importin-11 may destabilize PTEN, leading to the development of lung, prostate, and other cancers.

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  6. Plus-Sized Fly: A Model to Understand the Mechanisms Underlying Human ObesityRead the original story

    Jan 10, 2017 | Newswise

    Cold Spring Harbor, NY - Why do people become obese? Poor dietary choices and overeating seem like clear causes, but what is at the root of these behaviors? Significantly overweight people may be genetically predisposed to be affected disproportionately when faced with the ready availability of calorie-laden treats. It appears, in others words, that some people's genes place them at particular risk of gaining more weight than others in the modern food landscape.

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  7. Researchers Identify Potentially Druggable Mutant p53 Proteins That Promote Cancer GrowthRead the original story

    Dec 9, 2016 | Newswise

    Cold Spring Harbor, NY - Discovered in the 1970s, tumor suppressors are among the most important proteins in the body. A master regulator of growth -- "the guardian of the genome" -- the p53 protein monitors cell growth for errors.

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  8. Revolutionary Method to Map Brains at Single-Neuron Resolution Successfully DemonstratedRead the original story

    Aug 20, 2016 | Newswise

    Cold Spring Harbor, NY - Neuroscientists today publish in Neuron details of a revolutionary new way of mapping the brain at the resolution of individual neurons, which they have successfully demonstrated in the mouse brain. The new method, called MAPseq , makes it possible in a single experiment to trace the long-range projections of large numbers of individual neurons from a specific region or regions to wherever they lead in the brain - in experiments that are many times less expensive, labor-intensive and time-consuming than current mapping technologies allow.

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  9. Gene Hunters Find Rare Inherited Mutations Linked to Bipolar DisorderRead the original story

    Jun 27, 2016 | Newswise

    Using so-called next-generation genome sequencing, researchers at Johns Hopkins have identified 84 potential inherited gene mutations that may contribute to the most severe forms of bipolar disorder. About 5.6 million Americans are estimated to have bipolar disorder.

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  10. 'Amazing Protein Diversity' Is Discovered in the Maize PlantRead the original story

    Jun 24, 2016 | Newswise

    Cold Spring Harbor, NY -- The genome of the corn plant - or maize, as it's called almost everywhere except the US - "is a lot more exciting" than scientists have previously believed. So says the lead scientist in a new effort to analyze and annotate the depth of the plant's genetic resources.

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  11. Summer Session Fruit Fly Data Leads to Promising New Target in Colorectal CancerRead the original story

    Jun 16, 2016 | Newswise

    In summer 2011, University of Colorado Cancer Center investigators Joaquin Espinosa, PhD, and Matthew Galbraith, PhD, taught a summer symposium on gene expression at Cold Spring Harbor Laboratory in Long Island, New York. As part of the three-week course, one of their students, Joel Perrez-Perri from Dr. Pablo Wappner's lab at the Instituto Leloir in Buenos Aires, Argentina, presented data from experiments on fruit flies describing the role of the histone acetyl-transferase TIP60 in regulating the expression of genes controlled by a protein known as HIF1A.

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