Cold Spring Harbor Newswire

Cold Spring Harbor Newswire

Comprehensive Real-Time News Feed for Cold Spring Harbor, NY.

Results 1 - 20 of 33 for "u:medicalxpress.com" in Cold Spring Harbor, NY

  1. Throwing molecular wrench into gene control machine leads to 'melting away' of leukemiaRead the original story w/Photo

    Monday Jan 8 | PhysOrg Weblog

    By inducing the expression of a small peptide in mouse models of human AML, CSHL researchers were able to prevent MYB, a major cancer enabler, from promoting cancer growth. Imaged 9, 11, and 13 days following introduction of the peptide, mice from the experiments show dramatic differences in outcome.

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  2. Physicists negate century-old assumption regarding neurons and brain activityRead the original story w/Photo

    Thursday Dec 21 | PhysOrg Weblog

    The old scheme for a neuron functioning as an excitable unit , and the new one with left/right/down sensitivities Credit: Prof. Ido Kanter Neurons are the basic computational building blocks that compose our brain.

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  3. New Lyme disease tests could offer quicker, more accurate detectionRead the original story w/Photo

    Dec 6, 2017 | PhysOrg Weblog

    New tests to detect early Lyme disease - which is increasing beyond the summer months -could replace existing tests that often do not clearly identify the infection before health problems occur. In an analysis published on December 7 in Clinical Infectious Diseases , scientists from Rutgers University, Harvard University, Yale University, National Institute of Allergy and Infectious Diseases of the NIH and other academic centers, industry and public health agencies say new diagnostic methods offer a better chance for more accurate detection of the infection from the Lyme bacteria.

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  4. New method to determine before surgery which prostate tumors pose a lethal threatRead the original story w/Photo

    Dec 1, 2017 | PhysOrg Weblog

    Screen shot from a new genome-viewing program that displays results of CSHL's innovative method for analyzing diagnostic prostate biopsy results. Arrayed in columns from left to right are genomic profiles of each of several hundred prostate cells sampled from an inidivual's 13 biopsy cores.

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  5. Study finds a new way to shut down cancer cells' ability to consume glucoseRead the original story w/Photo

    Nov 7, 2017 | PhysOrg Weblog

    Joaquin Espinosa, PhD, Matthew Galbraith, PhD, and University of Colorado Cancer Center colleagues demonstrate link between gene CDK8 and the ability of cancer to uptake and metabolize glucose. Credit: University of Colorado Cancer Center Cancer cells consume exorbitant amounts of glucose, a key source of energy, and shutting down this glucose consumption has long been considered a logical therapeutic strategy.

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  6. A new method accelerates the mapping of genes in the 'Dark Matter' of our DNARead the original story w/Photo

    Nov 6, 2017 | PhysOrg Weblog

    The information in the sequence of the human genome has a paramount importance in biomedical research. However, the value of this information is very limited in absence of a detailed map of the genes encoded in the genome.

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  7. Fantastic journey: How newborn neurons to find their proper place in the adult brainRead the original story w/Photo

    Nov 2, 2017 | PhysOrg Weblog

    Baby neurons -- neuroblasts -- migrate from their birthplace to positions in the olfactory bulb of adult mice thanks to two forces, one pulling from the front, the other pushing from behind. A single protein called DOCK7 helps to orchestrate these two steps.

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  8. Promise seen in possible treatment for autism spectrum disorderRead the original story w/Photo

    Nov 1, 2017 | PhysOrg Weblog

    In searching for a potential therapeutic for autism spectrum disorder, researchers have found that R-Baclofen reverses cognitive deficits and improves social interactions in two lines of 16p11.2 deletion mice. Credit: Picower Institute for Learning and Memory Human chromosome 16p11.2 deletion syndrome is caused by the absence of about 27 genes on chromosome 16. This deletion is characterized by intellectual disability; impaired language, communication, and socialization skills; and autism spectrum disorder or ASD.

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  9. Research revises our knowledge of how the brain learns to fearRead the original story w/Photo

    Oct 23, 2017 | PhysOrg Weblog

    A subset of neurons shown here, called PKC delta-expressing cells, located in the brain's central amygdala, drive aversive learning in mice, neuroscientists from CSHL have demonstrated. Credit: Li Lab CSHL Our brains wire themselves up during development according to a series of remarkable genetic programs that have evolved over millions of years.

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  10. Fundamental research enhances understanding of major cancer geneRead the original story w/Photo

    Oct 19, 2017 | PhysOrg Weblog

    The protein produced by the key cancer gene PTEN is involved in the destruction of a signalling molecule called PI P2. Amount of PI P2 seems to be linked to cancer growth and progression, especially in the prostate.

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  11. How honeybees read the waggle danceRead the original story w/Photo

    Oct 9, 2017 | PhysOrg Weblog

    Left: To inform their hivemates about the location of profitable flowers, a honeybee performs the waggle dance with specific vibration patterns. Right: Composite image of three interneurons in the honeybee brain which show unique responses to such vibrations.

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  12. Watch out! Brain network calculates impact of approaching objectRead the original story w/Photo

    Oct 9, 2017 | PhysOrg Weblog

    A neuroimaging study of two monkeys published in Journal of Neuroscience identifies a brain network that tracks the location of an object approaching the face and anticipates its potential consequences upon making contact with the body. Using functional resonance magnetic imaging in two resus monkeys, Suliann Ben Hamed and colleagues found a brain network linking occipital, parietal, premotor and prefrontal regions that is maximally activated when a virtual cone rapidly approaching the monkey was paired with a puff of air to the monkey's cheek, delivered when the object would be expected to reach the face in a real-world setting.

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  13. Safe to treat dementia patients with clot-busting drugsRead the original story w/Photo

    Oct 9, 2017 | PhysOrg Weblog

    Stroke patients with dementia treated with intravenous thrombolysis using powerful clot-busting drugs are at no higher risk of brain haemorrhage or death than other patients receiving the same treatment, a study from Karolinska Institutet published in the journal Neurology reports. Ischemic stroke is the most common form of stroke and is caused when a blood clot blocks the blood flow to the brain.

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  14. Researchers test psychedelic on cerebral organoidsRead the original story w/Photo

    Oct 9, 2017 | PhysOrg Weblog

    A Brazilian study, published in Scientific Reports on October 09, 2017, has identified changes in signaling pathways associated with neural plasticity, inflammation and neurodegeneration triggered by a compound from the family of dimethyltryptamine known as 5-MeO-DMT. "We describe for the first time psychedelic-related changes in the molecular functioning of human neural tissue," says Stevens Rehen, study leader, Professor of Federal University of Rio de Janeiro and Head of Research at D"Or Institute for Research and Education .

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  15. First cell-type census of mouse brains: Surprises about structure, male-female differencesRead the original story w/Photo

    Oct 5, 2017 | PhysOrg Weblog

    Pavel Osten's team used their qBrain brain-mapping platform to visualize and count inhibitory neurons in the mouse brain. Brainwide distribution of the 3 major inhibitory cell types, expressing neuropeptides called SST, PV and VIP, is shown in this color-coded composite.

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  16. White supremacy-the dark side of eugenicsRead the original story w/Photo

    Sep 22, 2017 | PhysOrg Weblog

    Whenever I work on a new edition of my human genetics textbook and reach the section on eugenics, at the end of an evolution chapter, I'm relieved that it's history. But this summer, as I wrapped up the 12th edition, the eugenics coverage took on a frightening new reality.

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  17. Neuron types in brain are defined by gene activity shaping their communication patternsRead the original story w/Photo

    Sep 21, 2017 | PhysOrg Weblog

    Patterns of cell-to-cell communication are the core feature that makes possible rigorous distinctions among neuron types across the mouse brain. This discovery by CSHL researchers was made through analysis of the gene activity profiles of these 6 known inhibitory cell types.

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  18. Research reveals 'exquisite selectivity' of neuronal wiring in the cerebral cortexRead the original story w/Photo

    Aug 21, 2017 | PhysOrg Weblog

    The CSHL team traced local and long-range connections of chandelier cells in the mouse brain. Arrow heads point to two of the chandelier cell soma or cell bodies, from each of which hundreds of candelabra-like arbors reach out to connect with local pyramidal neurons in a part of the cerebral cortex.

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  19. Long-sought mechanism of metastasis is discovered in pancreatic cancerRead the original story w/Photo

    Jul 27, 2017 | PhysOrg Weblog

    To trace the cause of metastasis in pancreatic cancer, the CSHL team used cells sampled from six mice to grow paired sets of pancreatic organoids -- balls of cells that develop in 3-D culture. The mice had gene mutations that induced pancreatic ductal cancer.

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  20. Want to win at sports? Take a cue from these mighty miceRead the original story w/Photo

    Jul 20, 2017 | PhysOrg Weblog

    As student athletes hit training fields this summer to gain the competitive edge, a new study shows how the experiences of a tiny mouse can put them on the path to winning. Scientists examined how surges of testosterone both before and after aggressive encounters led the male California mouse to win in future matches.

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