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  1. Structural fidelity and NMR relaxation analysis in a prototype RNA hairpin.Read the original story

    Monday Apr 27 | CiteULike

    RNA , Vol. 21, No. 5. , pp. 963-974, doi:10.1261/rna.047357.114 RNA hairpins are widespread and very stable motifs that contribute decisively to RNA folding and biological function.


  2. A pooling-based approach to mapping genetic variants associated with DNA methylation.Read the original story

    Sunday Apr 26 | CiteULike

    DNA methylation is an epigenetic modification that plays a key role in gene regulation. Previous studies have investigated its genetic basis by mapping genetic variants that are associated with DNA methylation at specific sites, but these have been limited to microarrays that cover less than 2% of the genome and cannot account for allele-specific methylation .


  3. Systematic interaction network filtering identifies CRMP1 as a novel...Read the original story

    Saturday Apr 25 | CiteULike

    Assemblies of huntingtin fragments with expanded polyglutamine tracts are a pathological hallmark of Huntington's disease . The molecular mechanisms by which these structures are formed and cause neuronal dysfunction and toxicity are poorly understood.


  4. Animal-to-Animal Variability in Neuromodulation and Circuit Function.Read the original story

    Thursday Apr 23 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Each animal alive in the world is different from all other individuals, while sharing most attributes of form and function with others of the same species.


  5. Associative Learning in Invertebrates.Read the original story

    Thursday Apr 23 | CiteULike

    This work reviews research on neural mechanisms of two types of associative learning in the marine mollusk Aplysia, classical conditioning of the gill- and siphon-withdrawal reflex and operant conditioning of feeding behavior. Basic classical conditioning is caused in part by activity-dependent facilitation at sensory neuron-motor neuron synapses and involves a hybrid combination of activity-dependent presynaptic facilitation and Hebbian potentiation, which are coordinated by trans-synaptic signaling.


  6. Germline and somatic imprinting in the nonhuman primate highlights...Read the original story

    Sunday Apr 12 | CiteULike

    Genomic imprinting is an epigenetic mechanism resulting in parental allele-specific gene expression. Defects in normal imprinting are found in cancer, assisted reproductive technologies, and several human syndromes.


  7. The discovery of integrated gene networks for autism and related disorders.Read the original story

    Monday Apr 6 | CiteULike

    Despite considerable genetic heterogeneity underlying neurodevelopmental diseases, there is compelling evidence that many disease genes will map to a much smaller number of biological subnetworks. We developed a computational method, termed MAGI , that simultaneously integrates protein-protein interactions and RNA-seq expression profiles during brain development to discover "modules" enriched for de novo mutations in probands.


  8. The IRF family transcription factors at the interface of innate and adaptive immune responses.Read the original story

    Saturday Apr 4 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. The interferon-regulatory factor family, originally identified as transcriptional regulators of the type I interferon system, consists of nine members in mammals.


  9. Adult Neurogenesis in Neurodegenerative Diseases.Read the original story

    Apr 3, 2015 | CiteULike

    Adult neurogenesis is limited to specific brain regions in the mammalian brain, such as the hippocampal dentate gyrus and the subventricular zone/olfactory bulb system. Alterations in adult neurogenesis appear to be a common hallmark in different neurodegenerative diseases including Parkinson's disease , Alzheimer's disease , and Huntington's disease .


  10. Accurate typing of short tandem repeats from genome-wide sequencing data and its applications.Read the original story

    Apr 1, 2015 | CiteULike

    Short Tandem Repeats are implicated in dozens of human genetic diseases and contribute significantly to genome variation and instability. Yet profiling STRs from short-read sequencing data is challenging because of their high sequencing error rates.


  11. Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells.Read the original story

    Mar 27, 2015 | CiteULike

    Recently, a handful of intergenic long noncoding RNAs have been shown to compete with mRNAs for binding to miRNAs and to contribute to development and disease. Beyond these reports, little is yet known of the extent and functional consequences of miRNA-mediated regulation of mRNA levels by lncRNAs.


  12. A cloud-compatible bioinformatics pipeline for ultrarapid pathogen...Read the original story

    Mar 24, 2015 | CiteULike

    Unbiased next-generation sequencing approaches enable comprehensive pathogen detection in the clinical microbiology laboratory and have numerous applications for public health surveillance, outbreak investigation, and the diagnosis of infectious diseases. However, practical deployment of the technology is hindered by the bioinformatics challenge of analyzing results accurately and in a clinically relevant timeframe.


  13. Genetic Dissection of Memory Formation in Drosophila melanogasterRead the original story

    Mar 21, 2015 | CiteULike

    Cold Spring Harbor Symposia on Quantitative Biology , Vol. 55 , pp. 203-211, doi:10.1101/sqb.1990.055.01.022 To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document.


  14. A recent bottleneck of Y chromosome diversity coincides with a global change in culture.Read the original story

    Mar 20, 2015 | CiteULike

    It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50-100 thousand yr ago . Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples.


  15. Mitochondria and cancer: Warburg addressed.Read the original story

    Mar 19, 2015 | CiteULike

    Cold Spring Harbor symposia on quantitative biology , Vol. 70 , pp. 363-374, doi:10.1101/sqb.2005.70.035 Otto Warburg recognized that cancer cells generate excessive lactate in the presence of oxygen .


  16. The E-Id protein axis modulates the activities of the...Read the original story

    Feb 23, 2015 | CiteULike

    The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis. It is now well established that the E and Id protein axis regulates multiple steps in lymphocyte development.


  17. MIPSTR: a method for multiplex genotyping of germline and somatic STR ...Read the original story

    Feb 11, 2015 | CiteULike

    Abstract Short tandem repeats are highly mutable genetic elements that often reside in functional genomic regions. The cumulative evidence of genetic studies on individual STRs suggests that STR variation profoundly affects phenotype and contributes to trait heritability.


  18. SWORD - a highly efficient protein database searchRead the original story

    Feb 6, 2015 | CiteULike

    For decades, it has been explored and solved using different exact and heuristic approaches. However, exponential growth of data in size in recent years has brought significant challenges in improving already existing algorithms.


  19. Molecular dissection of the genetic mechanisms that underlie...Read the original story

    Jan 27, 2015 | CiteULike

    Recent studies have shown a surprising phenomenon, whereby orthologous regulatory regions from different species drive similar expression levels despite being highly diverged in sequence. Here, we investigated this phenomenon by genomically integrating hundreds of ribosomal protein promoters from nine different yeast species into S. cerevisiae and accurately measuring their activity.


  20. Statistical Kinetics of Processive EnzymesRead the original story

    Jan 21, 2015 | CiteULike

    Cold Spring Harbor Symposia on Quantitative Biology , Vol. 60 , pp. 793-802, doi:10.1101/sqb.1995.060.01.085 To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document.


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