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Results 1 - 20 of 87 for "u:citeulike.org" in Cold Spring Harbor, NY

  1. Assessing the reliability of spike-in normalization for analyses of single-cell RNA sequencing data.Read the original story

    15 hrs ago | CiteULike

    By profiling the transcriptomes of individual cells, single-cell RNA sequencing provides unparalleled resolution to study cellular heterogeneity. However, this comes at the cost of high technical noise, including cell-specific biases in capture efficiency and library generation.

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  2. Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis.Read the original story

    Friday Oct 13 | CiteULike

    The impact of inherited genetic variation on gene expression in humans is well-established. The majority of known expression quantitative trait loci impact expression of local genes .

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  3. Erasure and reestablishment of random allelic expression imbalance after epigenetic reprogramming.Read the original story

    Thursday Oct 12 | CiteULike

    RNA , Vol. 22, No. 10. , pp. 1620-1630, doi:10.1261/rna.058347.116 To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document.

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  4. High-throughput allele-specific expression across 250 environmental conditions.Read the original story

    Sunday Oct 1 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Gene-by-environment interactions determine common disease risk factors and biomedically relevant complex traits.

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  5. Transcriptional correlates of memory maintenance following long-term...Read the original story

    Saturday Sep 30 | CiteULike

    We characterized the transcriptional response accompanying maintenance of long-term sensitization memory in the pleural ganglia of Aplysia californica using microarray and qPCR . We found that 24 h after memory induction there is strong regulation of 1198 transcripts in a pattern that is almost completely distinct from what is observed during memory encoding .

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  6. Lymphangiogenesis guidance by paracrine and pericellular factors.Read the original story

    Thursday Sep 28 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Lymphatic vessels are important for tissue fluid homeostasis, lipid absorption, and immune cell trafficking and are involved in the pathogenesis of several human diseases.

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  7. Sirtuins in Aging and DiseaseRead the original story

    Monday Sep 25 | CiteULike

    Cold Spring Harbor Symposia on Quantitative Biology , Vol. 72 , pp. 483-488, doi:10.1101/sqb.2007.72.024 Sirtuin genes function as anti-aging genes in yeast, Caenorhabditis elegans, and Drosophila.

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  8. UMI-tools: modeling sequencing errors in Unique Molecular Identifiers ...Read the original story

    Monday Sep 18 | CiteULike

    Unique Molecular Identifiers are random oligonucleotide barcodes that are increasingly used in high-throughput sequencing experiments. Through a UMI, identical copies arising from distinct molecules can be distinguished from those arising through PCR amplification of the same molecule.

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  9. Sasquatch: predicting the impact of regulatory SNPs on transcription...Read the original story

    Sep 15, 2017 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. In the era of genome-wide association studies and personalized medicine, predicting the impact of single nucleotide polymorphisms in regulatory elements is an important goal.

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  10. Detection of long repeat expansions from PCR-free whole-genome sequence data.Read the original story

    Sep 14, 2017 | CiteULike

    Identifying large expansions of short tandem repeats such as those that cause amyotrophic lateral sclerosis and fragile X syndrome is challenging for short-read whole-genome sequencing data. A solution to this problem is an important step towards integrating WGS into precision medicine.

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  11. Hormone-dependent control of developmental timing through regulation of chromatin accessibility.Read the original story

    Sep 14, 2017 | CiteULike

    Specification of tissue identity during development requires precise coordination of gene expression in both space and time. Spatially, master regulatory transcription factors are required to control tissue-specific gene expression programs.

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  12. An atlas of alternative splicing profiles and functional associations ...Read the original story

    Sep 1, 2017 | CiteULike

    An atlas of alternative splicing profiles and functional associations reveals new regulatory programs and genes that simultaneously express multiple major isoforms. To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document.

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  13. Detection of structural mosaicism from targeted and whole-genome sequencing data.Read the original story

    Sep 1, 2017 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Structural mosaic abnormalities are large post-zygotic mutations present in a subset of cells and have been implicated in developmental disorders and cancer.

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  14. Regulation of the Bioavailability of TGF-I2 and TGF-I2-Related Proteins.Read the original story

    Aug 30, 2017 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. The bioavailability of members of the transforming growth factor I2 family is controlled by a number of mechanisms.

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  15. Structural Biology and Evolution of the TGF-I2 Family.Read the original story

    Aug 20, 2017 | CiteULike

    We review the evolution and structure of members of the transforming growth factor I2 family, antagonistic or agonistic modulators, and receptors that regulate TGF-I2 signaling in extracellular environments. The growth factor domain common to all family members and many of their antagonists evolved from a common cystine knot growth factor domain.

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  16. Agonists and Antagonists of TGF-I2 Family Ligands.Read the original story

    Aug 20, 2017 | CiteULike

    The discovery of the transforming growth factor I2 family ligands and the realization that their bioactivities need to be tightly controlled temporally and spatially led to intensive research that has identified a multitude of extracellular modulators of TGF-I2 family ligands, uncovered their functions in developmental and pathophysiological processes, defined the mechanisms of their activities, and explored potential modulator-based therapeutic applications in treating human diseases. These studies revealed a diverse repertoire of extracellular and membrane-associated molecules that are capable of modulating TGF-I2 family signals via control of ligand availability, processing, ligand-receptor interaction, and receptor activation.

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  17. Non-Smad Signaling Pathways of the TGF-I2 Family.Read the original story

    Aug 17, 2017 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Transforming growth factor I2 and structurally related factors use several intracellular signaling pathways in addition to Smad signaling to regulate a wide array of cellular functions.

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  18. Posttranslational Regulation of Smads.Read the original story

    Aug 17, 2017 | CiteULike

    Transforming growth factor I2 family signaling dictates highly complex programs of gene expression responses, which are extensively regulated at multiple levels and vary depending on the physiological context. The formation, activation, and destruction of two major functional complexes in the TGF-I2 signaling pathway are direct targets for posttranslational regulation.

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  19. Regulation of TGF-I2 Family Signaling by Inhibitory Smads.Read the original story

    Aug 17, 2017 | CiteULike

    To insert individual citation into a bibliography in a word-processor, select your preferred citation style below and drag-and-drop it into the document. Inhibitory Smads have conserved carboxy-terminal MH2 domains but highly divergent amino-terminal regions when compared with receptor-regulated Smads and common-partner Smads .

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  20. Genetic PrP Prion Diseases.Read the original story

    Aug 13, 2017 | CiteULike

    Genetic prion diseases caused by mutations in the prion protein gene have been classified as genetic Creutzfeldt-Jakob disease, Gerstmann-Straussler-Scheinker disease, or fatal familial insomnia. Mutations in PRNP can be missense, nonsense, and/or octapeptide repeat insertions or, possibly, deletions.

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