Bethesda Newswire

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  1. US societies push back against NIH reproducibility guidelinesRead the original story w/Photo

    Yesterday | NatureNews

    Many journals have introduced checklists to comply with NIH guidelines for reproducibility in research. But some societies are not happy with the "one-size-fits-all" approach.


  2. Carcinogenesis & Cancer GeneticsRead the original story

    Monday Apr 13 | The Journal of Investigative Dermatology

    We also found DC-HIL expression to be induced by melanoma on blood circulating myeloid-derived suppressor cells that promote the cancer’s progression. Using the CD14 low phenotype to mark MDSC in humans, we showed: strong positive correlation between advancing melanoma stage and blood burden of DC-HIL MDSC; quick decline of this blood level after surgical resection of early melanoma; and restoration by anti-DC-HIL mAb of depressed T-cell interferon-gamma response associated with melanoma to near-normal levels.


  3. Loss of Feedback Inhibition via D2 Autoreceptors Enhances Acquisition ...Read the original story

    Monday Apr 13 | Neuropsychopharmacology

    Understanding the factors that regulate cue reactivity will be vital for improving treatment of addictive disorders. Low availability of dopamine D2 receptors in the striatum is associated with high cocaine intake and compulsive use.


  4. Molecular Genetics of Visual Circuit FormationRead the original story

    Saturday Apr 11 | Nature Neuroscience

    A postdoctoral fellow position is available in the Retinal Circuits Development and Genetics Unit of the National Eye Institute on the National Institutes of Health campus in Bethesda, Maryland, . The goal of our research is to understand how visual circuits develop and how they function.


  5. Antibody shows promise as treatment for HIVRead the original story w/Photo

    Wednesday Apr 8 | NatureNews

    Treating HIV with an antibody can reduce the levels of the virus in people's bodies - at least temporarily, scientists report on 8 April in Nature 1 . The approach, called passive immunization, involves infusing antibodies into a person's blood.


  6. Career paths: Staff scientists backedRead the original story

    Wednesday Apr 8 | Nature

    Non-faculty researchers in university labs and core facilities will soon be able to apply for grants from the US National Cancer Institute in Bethesda, Maryland. The 'research specialist' award addresses the unsustainable growth in the number of postdoctoral positions and reflects an effort to both develop new career paths and provide stability for biomedical labs, says Dinah Singer, director of the institute's division of cancer biology.


  7. Federalist principles for healthcare data networksRead the original story

    Tuesday Apr 7 | Nature Biotechnology

    Instrumenting the health system for discovery promises the identification of new drug targets, repositioning of medications, partitioning of populations for personalized medicine, quantification of the impact of environment on disease, comparison of the effectiveness of treatments and postmarket surveillance of therapeutics. EHRs have already spawned 'big data' about patients, including diagnoses, notes, laboratory results and medications.


  8. Naive CD8+ T-cell precursors display structured TCR repertoires and...Read the original story

    Tuesday Mar 24 | Immunology and Cell Biology

    E-mail: ; Dr JJ Miles, Human Immunity Laboratory, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia. E-mail: Basic parameters of the naive antigen -specific T-cell repertoire in humans remain poorly defined.


  9. Ebola's fast evolution questionedRead the original story w/Photo

    Thursday Mar 26 | NatureNews

    Genome sequencing study finds the virus evolving more slowly than thought, but others say the focus should be on monitoring the effects of new mutations A woman gets vaccinated on 10 March 2015 at a health centre in Conakry, Guinea, during the first clinical trials of the VSV-EBOV vaccine against the Ebola virus. The Ebola virus is evolving more slowly than was previously thought, contends a controversial new study of viral genomes from the current West African epidemic.


  10. Director, Division of NeuroscienceRead the original story

    Saturday Mar 21 | Nature Neuroscience

    The Director is responsible for planning, directing and evaluating extramural and collaborative research and training in the three DN branches: Neurobiology of Aging, Behavioral and Systems Neuroscience, and Dementias of Aging {for a more detailed description of the research areas supported and fostered by DN, please follow this link}. The Institute in Alzheimer's disease research and the Dementias Branch directs all aspects of research on Alzheimer's disease from basic neuroscience to translational research and clinical trials of new therapeutic interventions.


  11. Mistrust and meddling unsettles US science agencyRead the original story w/Photo

    Mar 10, 2015 | NatureNews

    The US National Science Foundation has had a tough couple of years. Republicans in the US Congress have put the agency under the microscope, questioning its decisions on individual grants and the purpose of entire fields of study.


  12. Analysis of variants and mutations in the human winged helix FOXA3...Read the original story

    Mar 3, 2015 | International Journal of Obesity

    E-mail: Received 22 September 2014; Revised 12 November 2014; Accepted 23 November 2014 Accepted article preview online 12 February 2015; Advance online publication 3 March 2015 The forkhead factor Foxa3 is involved in the early transcriptional events controlling adipocyte differentiation and plays a critical function in fat depot expansion in response to high-fat diet regimens and during aging in mice. No studies to date have assessed the potential associations of genetic variants in FOXA3 with human metabolic outcomes.


  13. Ebola survivors offer clues to body's virus defencesRead the original story w/Photo

    Mar 9, 2015 | NatureNews

    The human body can mobilize a strong defense against Ebola virus, suggests a study of four people with the virus who were treated in the United States last year. A team led by immunologist Rafi Ahmed of Emory University in Atlanta, Georgia, found that the people treated at Emory between August and October 2014 mustered robust immune defences against the virus, which has killed nearly 10,000 people in West Africa in 15 months.


  14. Astroglial Glutamate Transporter Deficiency Increases Synaptic...Read the original story

    Feb 25, 2015 | Neuropsychopharmacology

    Correspondence: Professor K Tanaka, Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-Ku, Tokyo 113-8510, Japan, Tel: +81 3 5803 5846, Fax: +81 3 5803 5843, E-mail: Received 20 May 2014; Revised 10 January 2015; Accepted 10 January 2015 Accepted article preview online 9 February 2015; Advance online publication 25 February 2015 I ratio) has been proposed to underlie the pathogenesis of neuropsychiatric disorders, such as autism spectrum disorders , obsessive-compulsive disorder , and Tourette’s syndrome . A proper E I ratio is achieved via factors expressed in neuron and glia.


  15. Researchers seek definition of head-trauma disorderRead the original story w/Photo

    Feb 25, 2015 | NatureNews

    Dave Duerson suspected that something was wrong with his brain. By 2011, 18 years after the former American football player had retired from the Phoenix Cardinals, he experienced frequent headaches, memory problems and an increasingly short temper.


  16. Marijuana flips appetite switch in brainRead the original story w/Photo

    Feb 18, 2015 | NatureNews

    Smoking marijuana may stoke a yearning for crisps, but understanding how it affects hunger is relevant not just to those who indulge in it. The drug has yielded a ripe target for scientists who seek to stimulate or suppress appetite: the receptor CB1, found in cells throughout the body.


  17. Lymphovascular invasion is significantly associated with biochemical...Read the original story

    Feb 10, 2015 | Prostate Cancer and Prostatic Diseases

    Correspondence: Dr K Mitsuzuka, Department of Urology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan. E-mail: The significance of lymphovascular invasion remains controversial, and the association of LVI with biochemical relapse was investigated in men treated with radical prostatectomy according to pathological results.


  18. A multigene array for measurable residual disease detection in AML patients undergoing SCTRead the original story

    Feb 9, 2015 | Bone Marrow Transplantation

    E-mail: AML is a diagnosis encompassing a diverse group of myeloid malignancies. Heterogeneous genetic etiology, together with the potential for oligoclonality within the individual patient, have made the identification of a single high-sensitivity marker of disease burden challenging.


  19. NIH defends monkey experimentsRead the original story w/Photo

    Jan 28, 2015 | NatureNews

    The US National Institutes of Health has modified the way a controversial lab studies stress in monkeys in response to criticism by animal-rights activists and members of Congress who say that the research is inhumane. At issue are experiments led by Stephen Suomi, a psychologist at the US National Institute of Child Health and Human Development in Poolesville, Maryland.


  20. Funding: Spread sparse grantsRead the original story

    Jan 28, 2015 | Nature

    Some well-funded researchers will soon have one fewer option for getting grants. Starting next year, the National Institute of General Medical Sciences in Bethesda, Maryland, will not award large grants to researchers who already have one.


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