Friday Dec 6
Nucleic Acids Research
Combining Hi-C data with phylogenetic correlation to predict the...
Defining the target genes of distal regulatory elements , such as enhancer, repressors and insulators, is a challenging task.
3D Chromosome Modeling with Semi-Definite Programming and Hi-C Data
For a long period of time, scientists studied genomes while assuming they are linear.
The EMBO Journal
Cohesin's role as an active chromatin domain anchorage revealed
Cohesin is a conserved protein complex indispensible for proper cell division, because it secures sister-chromatid cohesion following DNA replication until segregation is required at the onset of anaphase.
[Research Article] Organization of the Mitotic Chromosome
The three-dimensional organization of chromosomal DNA within the cell nucleus plays an important role in gene regulation.
R & D
Cost-effective method accurately orders DNA sequencing along entire chromosomes
A new computational method has been shown to quickly assign, order and orient DNA sequencing information along entire chromosomes.
Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions.
Genomes assembled de novo from short reads are highly fragmented relative to the finished chromosomes of Homo sapiens and key model organisms generated by the Human Genome Project.