Monday Apr 14
Nucleic Acids Research
Large-scale reconstruction of 3D structures of human chromosomes from chromosomal contact data
Chromosomes are not positioned randomly within a nucleus, but instead, they adopt preferred spatial conformations to facilitate necessary long-range gene-gene interactions and regulations.
HiCNorm: removing biases in Hi-C data via Poisson regression.
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Statistical confidence estimation for Hi-C data reveals regulatory chromatin contacts
Our current understanding of how DNA is packed in the nucleus is most accurate at the fine scale of individual nucleosomes and at the large scale of chromosome territories.