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Aug 20, 2013

jolenerosdale Profile

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The Koyal Group Info Mag - SA konference for at markere e...

Omkring 650 mineindustrien fagfolk forventes at deltage i konferencen i Adelaide Convention Center på fredag, og vil blive åbnet af SA's kasserer og minister for mineralske ressourcer og energi, Tom Koutsantonis MP. Keynote adresser vil være fra den ledende regering geolog, Dr Steve Hill, og Dr. Kathy Ehrig, de vigtigste Geometallurgist på BHP Billiton og præsentationer vil indebære betydelige minearbejdere i staten herunder BHP Billiton, OZ Minerals, Nyrstar, Hillgrove ressourcer, Valence industrier, Iluka ressourcer og Arrium minedrift. Relaterede stillinger: http://koyalgroupi http://koyalgroupi  (Dec 5, 2014 | post #1)

Houston, TX

Breakthrough shows how DNA is 'edited' to correct genetic...

The Koyal Group Info Mag News - An international team of scientists has made a major step forward in our understanding of how enzymes 'edit' genes, paving the way for correcting genetic diseases in patients. Researchers at the Universities of Bristol, Münster and the Lithuanian Institute of Biotechnology have observed the process by which a class of enzymes called CRISPR – pronounced 'crisper' – bind and alter the structure of DNA. The results, published in the Proceedings of the National Academy of Sciences (PNAS) today, provide a vital piece of the puzzle if these genome editing tools are ultimately going to be used to correct genetic diseases in humans. CRISPR enzymes were first discovered in bacteria in the 1980s as an immune defence used by bacteria against invading viruses. Scientists have more recently shown that one type of CRISPR enzyme – Cas9 – can be used to edit the human genome - the complete set of genetic information for humans. These enzymes have been tailored to accurately target a single combination of letters within the three billion base pairs of the DNA molecule. This is the equivalent of correcting a single misspelt word in a 23-volume encyclopaedia. To find this needle in a haystack, CRISPR enzymes use a molecule of RNA - a nucleic acid similar in structure to DNA. The targeting process requires the CRISPR enzymes to pull apart the DNA strands and insert the RNA to form a sequence-specific structure called an 'R-loop'. The global team tested the R-loop model using specially modified microscopes in which single DNA molecules are stretched in a magnetic field. By altering the twisting force on the DNA, the researchers could directly monitor R-loop formation events by individual CRISPR enzymes. This allowed them to reveal previously hidden steps in the process and to probe the influence of the sequence of DNA bases. Professor Mark Szczelkun, from Bristol University's School of Biochemistry, said: "An important challenge in exploiting these exciting genome editing tools is ensuring that only one specific location in a genome is targeted. "Our single molecule assays have led to a greater understanding of the influence of DNA sequence on R-loop formation. In the future this will help in the rational re-engineering of CRISPR enzymes to increase their accuracy and minimise off-target effects. This will be vital if we are to ultimately apply these tools to correct genetic diseases in patients." More discoveries you might want to know about http://koyalgroupi  (May 31, 2014 | post #1)

Chicago, IL

Japan's recovery from crisis, The Koyal Group updates

Five Years On, Japan Eyes Recovery from Crisis Japanese Prime Minister Shinzo Abe has put Japan back on the minds of global investors, as his policy mix of drastic monetary easing and fiscal stimulus has raised expectations that the economy may finally be exiting 15 years of deflation. But the move also marks a belated departure from traditional policy measures that had failed to get the world’s third-largest economy out of the ditch it fell into five years ago following a global financial crisis. Read full article here: http://blogs.wsj.c om/moneybeat/2013/ 09/14/five-years-o n-japan-eyes-recov ery-from-crisis/  (Sep 14, 2013 | post #1)