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Pharmacology

Why do you need inhibitors for kinetic studies?

I'm new to pharmacology,so could someone please explain why you need selective inhibitors to study something like metabolite formation? For example, why do you even need selective inhibitors of UGT enzymes which glucoronidate drugs in order to study glucoronidation kinetics? Why not just use mass spec to measure for glucoronidated product over different time points? Why do you even need to do inhibition studies in order to determine the rate of formation of glucoronidated product? Thanks in advance.  (Jul 14, 2012 | post #1)