May 16, 2008
Drug Combo Helps Women With Advanced Breast Cancer
A combination of two new-generation cancer drugs modestly delayed the time it took for cancer to worsen in a study of 300 women with very advanced disease who had stopped responding to other treatments.
It was the first test of these two highly targeted drugs, Herceptin and Tykerb. Both aim at a protein called HER-2/neu that is made in abnormally large quantities in about one-fourth of all breast cancers. Herceptin blocks the protein on the cell's surface; Tykerb does it inside the cell.
In the study, women getting the combo survived 12 weeks without their cancer worsening compared to eight weeks for those receiving Tykerb alone. Read more
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