Ringworms got to your brain.
Centrifugal force as a substitute for gravity, eh?
You have sure seen 2010 and the Russian ship that spun in the middle to simulate gravity. Visualize that ship heading for Jupiter with that middle spinning.
Let's get in the middle of that centrifuge and balance a six foot pole so it stands upright. You have your centrifugal force exerting acceleration across the cross section of the pole in a straight line. The arrested acceleration against the floor is equalized if the matter and density si even throughout the pole so it can be perpendicular. It also creates friction at that point of contact which in turn creates a fulcrum point for accelerations and decelerations working transversely to the force the centrifuge works.
Let's say you are moving thirty thousand miles per hour toward Jupiter. Your pole is balanced. Your engine misses a cylinder. A brief decrease in forward acceleration. What happens to the pole? It falls over and breaks its nose.
The geometry of gravity forces on the earth slows down the effect of those transverse forces, of which tidal forces are one. For the pole to fall over it has to fight the tug of gravity from all of those other directions. This gives some reaction time you will not get in the above scenario.
Your body cells will develop according to those simulated acceleration forces, in addition to trying to balance out the mass after being developed.
You're gonna get warped.
In addition to that you have the practical considerations of distributing mass equalizing about the axis of that centrifuge, and the longitudinal vibrations it will cause.
Batman Aura will be sitting in his nice new shiny spaceship, plot his course for the Pleiades, get up to speed, get up to get a beer out of the fridge, then fall on his face, knocking his ass out, and he will miss the turn at Andromeda and have his forward momentum arrested very suddenly when he impacts a small asteroid that didn't show up on his monitor. Of, course, that may have forestalled some serious vomiting episodes.
You won't colonize the universe unless you are in a spirit like form, something not affected by mass. You will need to switch off that Higg's boson. Believe or not, such is already done, but not in a manner you would consider human directed.
I love that bit: "...Your engine misses a cylinder..."
In deep space? That choked me up; now I have Cola going through my nose.
Lol. Okay Dave. Let us make nice. In space,.you do notbhave to worry about cylinders. Uhmkay?
Dave I know you think you always have something smart to say, always able to give a refutation at a moment's notice... But why not read up just a itsy bitsy teensy weensy little bit on the matter before commenting?