Posted in the Top Stories Forum
Since: Apr 13
#1 Apr 21, 2013
PAMAM as a drug carrier can improve the bioavailability and drug targeting of the oral drug. It has been a difficult problem for the biomedical field to develop new drug carriers to improve oral drugs bioavailability and drug targeting. By oral administration in mice experiments, tracking and monitoring anionic G6.0 PAMAM-COOH transport changes in the body through the mouth, we can get the following conclusions:(1) PAMAM-COOH as a drug carrier in mice body is stable.(2) PAMAM-COOH can enter mice through the oral administration, while maintaining the biological stability it can also enter the body circulation, distribute to a certain organ with the targeting.(3) 1mg/kg PAMAM-COOH taken by mouth has no drug toxicity, and there is no difference in the state of growth with normal mice. Based on this, we can determine PAMAM as a drug carrier has huge potential applications to improve oral drugs bioavailability and drug targeting. Weihai CY Dendrimer Technology Co.,Ltd. forwards from "Evidence of Oral Translocation of Anionic G6.5 Dendrimers in Mice" Giridhar Thiagarajan, United States, Shraddha Sadekar, United States, Mol.Pharmaceutics 2013, 10, 988-998.
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