Now i have to look it up and write in in english. lol<quoted text>
he's manually pollinating his lemon tree or he's got lots of insects in his room. lol
It'snot only the position of ERV's , nor the astronomical chance that about 14 are more orless at the same place, but that they have the same function in humans and monkey though the regulation is slightly different.
Lemons can wait a moment...education ongoing.
In this study we report main properties of Harbinger DNA transposons identified in protists, plants, insects,
worms, and vertebrates. This is the first superfamily of eukaryotic DNA transposons where all autonomous
transposons, even those that are hosted by species from different kingdoms, encode two proteins: a super-
family-specific transposase and a DNA-binding protein characterized by the presence of the conserved
SANT/myb/trihelix motif. The last motif is known to be important for the DNA binding by different tran-
scription regulators. Therefore, we suggest that this protein is necessary for coordinated expression of the
Harbinger transposase. Although mammalian genomes are free of recognizable remnants of Harbingers, we
identified a widely expressed HARBI1 gene encoding a 350-aa protein entirely derived from a Harbinger trans-
posase some 450500 million years ago. The HARBI1 proteins are conserved in humans, rats, mice, cows,
pigs, chickens, frogs, and various bony fish, as well as other extremely important proteins, including RAG1
and RAG2. Conserved motifs detected in the Harbinger transposases are also well preserved in the HARBI1
proteins. Therefore, the HARBI1 proteins are expected to be nucleases important for functioning of bony ver-
tebrates. We also found that the protein most similar to HARBI1 is encoded by an autonomous Harbinger
3_DR transposon that was transpositionally active in the zebrafish genome a few million years ago. Nonau-
tonomous transposons derived from Harbinger3_DR are characterized by a striking preference for a 17-bp
target site never seen previously in any other DNA transposon. Based on this observation, we suggest that the
hypothetical HARBI1 nucleases are also characterized by a strong DNA-target specificity.