Pharmacology question CYP
Posted in the Pharmacology Forum
#1 May 10, 2011
I have two questions about CYP450 and its isozymes. Does the metobolism of some drug, done by one of the isozymes, can affect metabolism of other?
For example: does metabolism of caffeine (1a2 iso) can interfere with metabolism of codeine (3a4 and 2d6)? Like slow it, or speed it up ?
Second one is familiar. Does metabolism of caffeine, can somehow slow aldehyde dehydrogenase?
I hope you could understand my questions, becouse I'm not native english speaker :)
#2 May 4, 2012
The cytochrome phenotype srereo isomer enzyme is the holy grail of your tolerability to certain drugs chiefly metabolized in the hepatic system. For example, if you livers ALT, formerly spgt is high like in fatty infiltration or hepatitis your tolerability to acetaminophen (Tylenol) is prolonged and the others half life is extended. One example is the drug Tagamet. If taken it will increase the elimination of Xanax quite a bit. The moan CYP450 isoenzme is the main enzyme for most drugs excreted in the liver. Main substrate are effected and many other isoenzmes play a pivotal part in prolongation or lessening of the efficacy of many Rx's. It's complicated, so always read your package insert or Physician's Desk Reference every time you are given a drug not previously taken.
#3 May 4, 2012
Caffiene is a sympathememetic. Thus increasing your BP- elimination (it is a diuretic) and thus it will enhance elimination of a MU agonist like codeine sulfate.
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