Why do you need inhibitors for kinetic studies?
Posted in the Pharmacology Forum
Since: Jul 12
#1 Jul 14, 2012
I'm new to pharmacology,so could someone please explain why you need selective inhibitors to study something like metabolite formation? For example, why do you even need selective inhibitors of UGT enzymes which glucoronidate drugs in order to study glucoronidation kinetics? Why not just use mass spec to measure for glucoronidated product over different time points? Why do you even need to do inhibition studies in order to determine the rate of formation of glucoronidated product? Thanks in advance.
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