p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway
There are 1 comment on the Cell Death and Differentiation story from Jun 10, 2013, titled p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway. In it, Cell Death and Differentiation reports that:
Correspondence: J Haigh, Department for Biomedical Molecular Biology, Ghent University, Technologiepark 927, Ghent , 9052 Belgium.
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#1 Jun 17, 2013
p53 tumour suppressor downregulates vascular endothelial growth factor (VEGF) expression, p53 rapidly induces VEGF transcription upon hypoxia exposure by binding processes, within an HIF-1α-, to a highly conserved and functional p53-binding site within the VEGF promoter. However, during sustained hypoxia, p53 indirectly downregulates VasEGF expression via the retinoblastoma (Rb) pathway in a p21-dependent manner, which is distinct from its role in cell-cycle regulation., especially for tumours that harbour wild-type TP53 and a dysfunctional Rb pathway p 55 plays a major role as well'
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