p53 promotes VEGF expression and angi...

p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway

There are 1 comment on the Cell Death and Differentiation story from Jun 10, 2013, titled p53 promotes VEGF expression and angiogenesis in the absence of an intact p21-Rb pathway. In it, Cell Death and Differentiation reports that:

Correspondence: J Haigh, Department for Biomedical Molecular Biology, Ghent University, Technologiepark 927, Ghent , 9052 Belgium.

Join the discussion below, or Read more at Cell Death and Differentiation.

andrew j langham

London, UK

#1 Jun 17, 2013
p53 tumour suppressor downregulates vascular endothelial growth factor (VEGF) expression, p53 rapidly induces VEGF transcription upon hypoxia exposure by binding processes, within an HIF-1α-, to a highly conserved and functional p53-binding site within the VEGF promoter. However, during sustained hypoxia, p53 indirectly downregulates VasEGF expression via the retinoblastoma (Rb) pathway in a p21-dependent manner, which is distinct from its role in cell-cycle regulation., especially for tumours that harbour wild-type TP53 and a dysfunctional Rb pathway p 55 plays a major role as well'

Tell me when this thread is updated:

Subscribe Now Add to my Tracker

Add your comments below

Characters left: 4000

Please note by submitting this form you acknowledge that you have read the Terms of Service and the comment you are posting is in compliance with such terms. Be polite. Inappropriate posts may be removed by the moderator. Send us your feedback.

Molecular Biology Discussions

Title Updated Last By Comments
Zika & Wolbachia research; (Oct '16) Oct '16 andrew john langham 1
News How our cells use mother's and father's genes (Sep '16) Sep '16 Stephany McDowell 1
News Rattlesnake Ancestor Was Venom Factory (Sep '16) Sep '16 Stephany McDowell 1
News How rattlesnakes got, and lost, their venom (Sep '16) Sep '16 Stephany McDowell 1
News Why scientists reconstructed an ancient plague (Aug '16) Aug '16 who do u call 1
News Ilex Medical Ltd. (ILX) - Financial and Strateg... (Mar '15) Mar '16 Anonymous 12
Software for Biologics Data Management (Mar '14) Mar '14 Ocimum 1
More from around the web