How to Enhance the solubility of GlibenClamide in buffer solution PH 1.2 ???

[fenny]

i'm doing some research for my final project.
My research is about dissolution of glibenclamide in many drug products.
i need information about cosolvent that can enhance the solubility of glibenclamide in buffer solution PH1.2
i've already tried 10%methanol to dissolved 0.15g glibenclamide then i added buffer solution PH 1.2ad.1L.
But it didn't give any absorbance. Do you know what should i do?
Any help would be appreciated.
Thanks !

[Lisa]

if you dilute glibenclamide in methanolic HCl 0,1 M you will have absorbance, with a maximum at 300 nm and a less intense maximum at 275 nm
source: Ph Eur, BP
([e-mail])

[RAKESH]

hi

COULD any body PLZ HELP BY LEtTING ME KNOW , HOW to PREPARED pH-1.2 BUFFER SOLUTION.

Thanking you

please mail me on [e-mail] or post in this forum

[RAKESH]

i DONT KNOW THE ANSWER FOR UR QUESTION, BUT COULD U PLZ HELP BY LEETING ME KNOW , HOW U PREPARED pH-1.2 BUFFER SOLUTION.

Thanking you

[amit kumar batra]

sir,
i want to carry out dissolution of glibenclamide in Hcl buffer pH 1.2,but it is not possible, so i selected pH 4.0 for dissolution media in acidic region. This pH was selected on the basis of pka (5.3)property of drug, can i do it or not.

[swarup mukherje]

is methanol a good solvent for formulation of glibenclamide?

[Ambekar Abdul Wahid]

Sir, kindlely give me the solubility of glebenclamide in various phospate buffer like pH 4, pH 6.8, pH 7.4 & pH 8. kindely also tell me how to select the media for permeation studies of Teansdermal drug delivery system

[deepak]

for preparing buffer pH 1.2(gastric simulated)you should dissolve 2g NaCl and 7 ml Conc HCl in 1000ml of water and adjust pH with HCl and NaoH

[saurav timilsina]

hey.. i'm trying to formulate a suatained release of antidiabetic drug. could anyone suggest for which i should be going? i mean selection criteria for the drugs

[daphne sherine]

hi
im doing project wit glibenclamide....
can anyone pls tel me the uv spectroscopical procedure and concentration range for glibenclamide/glyburide ,other than mentioned in pharmacopoeias.. or can u tel the beer's law range for pharmacopoeial procedure

[harish]

by preperation with cyclodextrine

[nitesh]

hee heee he e sorry dont know

[gaurav malviya]

same as harish ok