Brain cancer cell line whole-genome sequencing completed
Posted in the Cell Biology Forum
Since: May 12
#1 May 24, 2012
University of California at Los Angeles Jonsson Comprehensive Cancer Research Center scientists published in DSG2 the April 29 special issue of Public Library of Science Genetics that they have completed the first whole-genome sequencing of brain cancer cell line, which is as of a single cancer cell lines did the most thorough sequencing analysis. By using the latest technology, the sequencing of work to be completed within one month, sequencing costs about $ 35,000.This research has taken a new DSTYK step toward personalized treatment based on the unique biological signature of the individual cancer, they reveal new molecular targets will help to develop more effective and less toxic drugs. The study doctor earlier the better to find a new method of monitoring brain cancer recurrence can be useful, easy to make a diagnosis and treatment of DTNBP1 brain cancer recurrence. With this discovery, the clinician can also be determination of the exact time of brain cancer cells is inactivated in order to prevent excessive use of drugs on the human health damage caused.The sequencing work into human glioma cell line called U87, in over 1000 laboratories worldwide are using U87 cell lines to carry out research. Chose the cell line, because its the most fully. The sequencing work will enable those engaged in the study of DUSP1 cell lines scientists found their research to re-elaborate, and prompted them to propose a new forward direction.The sequencing revealed almost all of the potential cancer-causing chromosomal translocation and lead to the development of cancer gene deletion and mutation.Researchers from the long chain of genetic material out of the cell lines, and then randomly truncated. Billions of DUSP14 different DNA fragments in the cancer by a new generation of sequencing technology at the same time for reading, you can ensure that the results with high sensitivity and accuracy of genetic material through the analysis of more than 1 billion times.
The researchers said that a special information tool uses the most advanced technology, will greatly enhance the effectiveness of genetic analysis. Previously, scientists can not understand most of the mutations in a cancer, because they are invisible, and now this new technology will allow scientists to monitor each type of cancer, and its genome fully decoded, so the scientists will not miss a cancer-causing mutations.Know which genes mutate and drive the development of cancer, clinicians will be able to choose the most suitable for a specific molecular signature of attack cancer therapy, and thus provide more effective treatment to patients. The sequencing also show molecular abnormalities drive the development of cancer, reveals the target will contribute to the development of new therapies to attack only cancer cells without damage to healthy cells.The researchers also pointed out that the cancer genome sequencing diagram, the scientists will be able to develop a sensitive molecular detectors, looking for a unique gene mutation found only in cancer cells. As long as the detection of this mutation can determine the cancer had returned and, thus, the patient will be able to get aggressive treatment in the earliest stages of cancer recurrence. In turn, this detection method can also be used to determine whether the cancer has been effectively eliminated, thus timely termination of the treatment of harmful.
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