Is there a pathway for protein to be ...

Is there a pathway for protein to be converted to fat?

Posted in the Biochemistry Forum


Rocky Mount, NC

#1 Jan 2, 2011
I keep reading that excess dietary protein is somehow converted to fat.

However I can't find any direct pathway where this occurs in the human body.

Instead I find "indirect" fat storage due to excess protein intake. Either by supressing and invoking DNL or convesrion of carbohydrates or supressing lipolysis and/or increasing lipogenesis in the first place.

But no instances where protein is directly converted to fat(unless first converted to glucose "gluoneogensis" then stored as fat?)

Is there a pathway for this? If so what?

Tim Joseph

United States

#2 Jan 13, 2011
In the citric acid cycle, when excess proteins are broken down for energy storage, their constituent amino acids are converted to acetyl-CoA inside the mitochondrial matrix. Acetyl-CoA is converted to citrate and travels out of the mitochondria to the cytosol and is converted back to Acetyl-CoA. This is transformed into Malonyl-CoA, which through a series of steps is converted to palmitate (16:0). Palmitate can then be converted to other types fatty acids.

Rocky Mount, NC

#3 Jan 15, 2011
Thank you Tim

Since: Jun 11

Location hidden

#4 Aug 24, 2011
Hi mates,

There is no conversion between Protein/Carbs and Fat, the storage molecule is different. Glycogen is stored in the muscle and its storage is generally limited and short term while fat can build up as long term storage. If your body has excess calories for its metabolic need be that energy from protein, fat or carbs ingested the body will form triglycerides from long chain hydrocarbons and store it. If you eat to much protein your body will store more fat, however it is INCORRECT to say that protein is metabolically converted into fat.
If you were to eat a 7000 calorie excess of protein you most certainly would retain any fat you also ingested but you would not convert it to 2 pounds of fat you would excrete the majority of it. This would of course be a bad idea as your liver would be overtaxed for sure trying to process and excrete all that excess.

Hope you have got it. Cheers!!!
Reid Wilson
"Proteins And Amino Acids" : Musclefeast. com

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