Z-scale interpretation
Zahra

Islamabad, Pakistan

#1 Feb 14, 2011
Hi,

I need help in figuring out the amino acid descriptor z-scale.

I have a very basic assignment, how can i tell from the z-scale values whether an amino acid is
1) positive or negative
2) Hydrophobic or hydrophilic
Trem

Malmö, Sweden

#2 Oct 30, 2014
Zahra wrote:
Hi,
I need help in figuring out the amino acid descriptor z-scale.
I have a very basic assignment, how can i tell from the z-scale values whether an amino acid is
1) positive or negative
2) Hydrophobic or hydrophilic
I know this is a very old post, but since this page comes up in Google searches for z-scales, and information on z-scales online has been a little difficult for me, at least, it might be good to have a quick answer anyway.
The 3 Hellberg z-scales reflect hydrophilicity(z1),steric properties(z2) and electronic properties(z3). For instance, Phe has a very low z1-value due to its hydrophobicity, Trp has a high z2 due to its bulkyness, and Arg has a low z3 due to its positively charged side chain. There are other more exact ways of defining these properties, however, since the z-scales have been created by combining many different chemical measurements of amino acids into new descriptors using principal component analysis(PCA).
Source: Wikberg et.al,2010, "Introduction to Pharmaceutical Bioinformatics"

Tell me when this thread is updated:

Subscribe Now Add to my Tracker

Add your comments below

Characters left: 4000

Please note by submitting this form you acknowledge that you have read the Terms of Service and the comment you are posting is in compliance with such terms. Be polite. Inappropriate posts may be removed by the moderator. Send us your feedback.

Biochemistry Discussions

Title Updated Last By Comments
News University of Maryland researcher's published a... Feb 16 noobieR 1
News Poop, there it is: New test for exotic civet co... (Sep '13) Feb 8 Fancy Phart 4
News Dr. Hays Young, Dna Analyst and Technical Leade... Feb 6 Wildbird 1
Will this have ruined my health? Feb 2 Njhuckman 1
News Association of rare missense variants in the se... Dec '16 Stephany McDowell 1
News Researchers uncover a new mechanistic understan... Oct '16 Stephany McDowell 1
News Why the Air Force Wants to See Pilots' Sweat Sep '16 Stephany McDowell 3
More from around the web