Posted in the Biochemistry Forum
#1 Feb 14, 2011
I need help in figuring out the amino acid descriptor z-scale.
I have a very basic assignment, how can i tell from the z-scale values whether an amino acid is
1) positive or negative
2) Hydrophobic or hydrophilic
#2 Oct 30, 2014
I know this is a very old post, but since this page comes up in Google searches for z-scales, and information on z-scales online has been a little difficult for me, at least, it might be good to have a quick answer anyway.
The 3 Hellberg z-scales reflect hydrophilicity(z1),steric properties(z2) and electronic properties(z3). For instance, Phe has a very low z1-value due to its hydrophobicity, Trp has a high z2 due to its bulkyness, and Arg has a low z3 due to its positively charged side chain. There are other more exact ways of defining these properties, however, since the z-scales have been created by combining many different chemical measurements of amino acids into new descriptors using principal component analysis(PCA).
Source: Wikberg et.al,2010, "Introduction to Pharmaceutical Bioinformatics"
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