Evolution: Forget Random Mutation - V...

Evolution: Forget Random Mutation - Variation is the Real Issue

There are 18 comments on the www.scientificblogging.com story from Jul 30, 2008, titled Evolution: Forget Random Mutation - Variation is the Real Issue. In it, www.scientificblogging.com reports that:

Darwin is famous for convincingly arguing that natural selection can explain why living things have features that are well-matched to the environment they live in.

In the popular consciousness, evolution is often thought of as natural selection acting on random mutations to produce the amazing tricks and traits found in the living world. But 'random mutation' isn't quite right ...

Join the discussion below, or Read more at www.scientificblogging.com.

“Got Science?”

Since: Apr 07

Location hidden

#1 Jul 30, 2008
This genotype to phenotype causal chain is a terrifically interesting analysis.
truthist

United States

#2 Jul 30, 2008
This article is full of engineering concepts and terminology. Sweet language.

I would like to see the list of the central problems in biology at this time.
noshellswill

Jacksonville, FL

#3 Jul 31, 2008
The science issue is really neato. A DNA change will cause a protein change. Proteins build organisms ... change a protein change the organism. Then environmental competition picks the better organism. Pretty 1.2.3 eh ?

But, a "causal chain" from gene to successful organism HANGS UP in the enormous FOLDING SPACE of single protein molecules. Nobody can predict how a single change in a large protein changes it folding. So the changed organism can't be predicted from a changed gene.

WooHoo! From a scientists POV it's a wonderful issue filled with Nobel-Prize-winning problems to solve.
Cousin Jethro

Leesburg, FL

#4 Jul 31, 2008
The dualism factor strikes again: Lao Tzu speaks of this as Ti (Substance) and Yun (Function)...it seems the multiplicities of substances and their tails/tales of multifarious functions stream off everywhere and we often try to collect them in language bags: macro-micro, ontogeny-phylogeny, phenotype-genotype; sometimes it appears as mere attachment to language/words rather than concepts/realities...growing up one always heard, "well it's either their genes or their environment..." and then the talks sail off into that duality...duality itself is a modality close to monality, which is more where we are actually living, splitting the One to our convenient parts, postulation, perception, then spitting the words, oftime absent the love which binds...Love being that "this" which most represents the intersection of Ti(substance) and Yun(function), where both each become and reflect the other as in a greater One
John Briner

Vancouver, Canada

#5 Jul 31, 2008
Interesting perspective - thx

- John Briner

“a'Round We Go”

Since: Apr 08

AOL

#6 Jul 31, 2008
Remember don't marry your sister you brother.

“a'Round We Go”

Since: Apr 08

AOL

#7 Jul 31, 2008
Remember don't marry your sister or
brother.
Cousin Jethro

Leesburg, FL

#8 Jul 31, 2008
Sence wrote:
Remember don't marry your sister or
brother.
Too late!(just kidding) For most earthlings it would suffice to remind them of the command, "don't murder your sister or brother," then well after that, maybe yours could be added -- with the more vulgar version, too
Adrian in Tacoma

Bonney Lake, WA

#9 Jul 31, 2008
Can anyone say MRSA?... Hey Cash, what's with the James Bond look?!...(hee)
Cousin Jethro

Leesburg, FL

#10 Jul 31, 2008
Adrian in Tacoma wrote:
Can anyone say MRSA?... Hey Cash, what's with the James Bond look?!...(hee)
What's MRSA I'm too lazy to google it...that's not Cash it's his Boned Cloned
Zaphod Beeblebrox

Somerset, KY

#11 Jul 31, 2008
Methicillin-resistant Staphylococcus aureus

A very deadly staph infection that originally showed up in hospitals where it was not really a threat, but has started killing people in other locations because they don't know they have it until it is too late.
Cousin Jethro

Leesburg, FL

#12 Jul 31, 2008
Zaphod Beeblebrox wrote:
Methicillin-resistant Staphylococcus aureus
A very deadly staph infection that originally showed up in hospitals where it was not really a threat, but has started killing people in other locations because they don't know they have it until it is too late.
Thanks a lot I'm not sure I feel better already...glad I opted for a second Scotch tonight

“Women (and cats) of WoW unite!”

Since: Jul 07

San Diego, but now: The Woods

#13 Jul 31, 2008
That was a very interesting and well written article. Certainly there will be potential breakthroughs for disease prevention and eradication that will ensue should scientists unlock the formula for identifying the mechanisms of how various genes work together in concert and what rules apply (and don't).

Still, so much disease can be prevented by how we humans interact with our environment. For instance:

"Common complex disorders are disorders in which multiple genetic and/or environmental factors act together to influence the expression and severity of a disorder. Examples of common complex disorders include high blood pressure, obesity, and diabetes."

http://www.bioedonline.org/slides/slide01.cfm...

This caused me to wonder, will our bad habits cause our own genes to mutate until we are not just passing on a predisposition to a certain disease, but causing it to become more likely to be inherited directly?

Here's something else to consider. It is known that "advanced paternal age ... is characteristic of some new mutation genetic diseases." This makes it very important to plan for reproduction at the optimal time. There are also other types of disease associated with both paternal and maternal age.

http://www.bioedonline.org/slides/slide01.cfm...
http://www.sciencedaily.com/releases/2002/10/...
http://www.gynob.com/obpre.htm

I think that eventually women will be able to freeze eggs or embryos routinely to ensure that they have the optimum chance of healthy offspring.

http://www.sciencedirect.com/science...

It may seem like too much thinking and planning, but so are many things worth doing. Incidentally, San Diego has had a frozen zoo for decades. Now that's planning ahead.

http://cres.sandiegozoo.org/projects/gr_froze...

P.S. To Cash - how in the heck did you get to be so cool? "Will Solve Maxwell's Equations For Food," indeed. Somehow I have a feeling that pie is the food you have in mind.

P.P.S. To Adrian in Tacoma - yup, and we humans really had a hand in that mutation.

“Got Science?”

Since: Apr 07

Location hidden

#14 Aug 12, 2008
TrilbyKat wrote:
P.S. To Cash - how in the heck did you get to be so cool? "Will Solve Maxwell's Equations For Food," indeed. Somehow I have a feeling that pie is the food you have in mind.
P.P.S. To Adrian in Tacoma - yup, and we humans really had a hand in that mutation.
My dad! He won a Nobel Prize in Awesome decades before I did (though I got two.)
Cousin Jethro

Apopka, FL

#15 Aug 13, 2008
TrilbyKat wrote:
That was a very interesting and well written article. Certainly there will be potential breakthroughs for disease prevention and eradication that will ensue should scientists unlock the formula for identifying the mechanisms of how various genes work together in concert and what rules apply (and don't).
Still, so much disease can be prevented by how we humans interact with our environment. For instance:
"Common complex disorders are disorders in which multiple genetic and/or environmental factors act together to influence the expression and severity of a disorder. Examples of common complex disorders include high blood pressure, obesity, and diabetes."
http://www.bioedonline.org/slides/slide01.cfm...
This caused me to wonder, will our bad habits cause our own genes to mutate until we are not just passing on a predisposition to a certain disease, but causing it to become more likely to be inherited directly?
Here's something else to consider. It is known that "advanced paternal age ... is characteristic of some new mutation genetic diseases." This makes it very important to plan for reproduction at the optimal time. There are also other types of disease associated with both paternal and maternal age.
http://www.bioedonline.org/slides/slide01.cfm...
http://www.sciencedaily.com/releases/2002/10/...
http://www.gynob.com/obpre.htm
I think that eventually women will be able to freeze eggs or embryos routinely to ensure that they have the optimum chance of healthy offspring.
http://www.sciencedirect.com/science...
It may seem like too much thinking and planning, but so are many things worth doing. Incidentally, San Diego has had a frozen zoo for decades. Now that's planning ahead.
http://cres.sandiegozoo.org/projects/gr_froze...
P.S. To Cash - how in the heck did you get to be so cool? "Will Solve Maxwell's Equations For Food," indeed. Somehow I have a feeling that pie is the food you have in mind.
P.P.S. To Adrian in Tacoma - yup, and we humans really had a hand in that mutation.
Bravo -- one of the best thought out and prepared comments I've seen on any thread -- brings up the questions in my mind of micro-evolution vs macro-evolution; environmental habituational evolution vs cellular accidental evolution and variants...and perceptual evolution(s) within the 55 perception channels, say, like sense of time, sense of compass direction, sense of color hue and intensity, etc., sense of rightness, sense of goodness, senses of whatever including sense of sense and sense of nonsense -- this last being most majorly applied to approx. 97% of comments on threads as we all attempt to evolve, heal and stay whole
truthist

United States

#16 Aug 13, 2008
Cash wrote:
<quoted text>
My dad! He won a Nobel Prize in Awesome decades before I did (though I got two.)
Congratulations!

You are awesome.:)
truthist

United States

#17 Aug 13, 2008
TrilbyKat, you rock! Thanks.:)

(I agree, Cousin Jethro.)
satish kumar

Amsterdam, Netherlands

#18 Feb 24, 2009
Hai, i found good blog while i am on surfing. If u want more plz visit the blog.
http://www.biochemden.blogspot.com

thank u

Tell me when this thread is updated:

Subscribe Now Add to my Tracker

Add your comments below

Characters left: 4000

Please note by submitting this form you acknowledge that you have read the Terms of Service and the comment you are posting is in compliance with such terms. Be polite. Inappropriate posts may be removed by the moderator. Send us your feedback.

Biochemistry Discussions

Title Updated Last By Comments
Isolation of caffeine (Oct '06) May 13 Anonymous 13
Foods affecting body odor question (Oct '06) May 10 K in ct 54
News Video: 2 dudes start a fire tornado in slow motion (Nov '15) Jan '16 TOUJOURS PRET 5
dehydrogenase enzyme in the citric acid cycle? (Nov '15) Nov '15 Shanna 1
News Patent Awarded for Drug Developed to Fight Bald... (Aug '15) Sep '15 justinparson12 2
biochemistry jobs and paying (Jun '15) Jun '15 sachita 1
News Regular ibuprofen use can extend lifespan, rese... (Jan '15) Jan '15 Commander Bunny 1
More from around the web