Ottomans did not ruin the region. The Brits did.<quoted text>
Before the Brits, there was the Ottomans. And now there is the Iranians, It really never ends.
The real question - still not answered - is less from the historical and more from the contemporary Israeli point of view:
How do you negotiate "peace" with an entity whose sole reason for existing is to destroy you?
Iranians have done nothing. If Iran had wanted, it would have taken all of them centuries ago. Does the name Cyrus ring a bell?
Was Iran expanding when the European nations were colonizing the world using trade and deceit?
Now to your question, which I consider a great question. The answer is:
Sit down and talk!
The best example is the USSR, an entity, which was out to destroy the US. Right? Does Russia want to destroy the US and vice versa? Follow the example.