Are You Intelligently Designed?

Oct 23, 2012 Full story: The Capital-Journal 409

Sometimes, when I'm discussing or debating issues with online atheists, agnostics, and evolutionists, the huge topic of Intelligent Design comes up, and they ask me to explain the Intelligent Design hypothesis to them.

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““You must not lose faith ”

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#303 Feb 1, 2013
I find it rather worrying that those quoted in science-daily do not entirely seem to understand the process.
It seems to me like they are about to cure a symptom.

How will degradation or the enzym BACE act on the type II diabetes-linked islet amyloid polypeptide in form morphologically a similar species?(30)

““You must not lose faith ”

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#304 Feb 1, 2013
Some articles/factsheet.
As in exploring Alzheimer, diabetes II and glucose-regulation.
Given the function of the hormone IAPP.
http://www.wikigenes.org/e/gene/e/3375.html

““You must not lose faith ”

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#305 Feb 1, 2013
Knock out mice and rats are not people, but IAPP infusion causes anorexia in rats.
And there is a different way to reduce ghrelin and IAPP in rats.
http://ajpregu.physiology.org/content/271/6/R...
http://www.ncbi.nlm.nih.gov/pubmed/16002530

BUT

Abstract
The AT-rich cis-motif A elements of the insulin gene promoter contribute to directing the gene's expression to pancreatic β-cells, bound by a homeodomain-containing transcription factor, PDX-1/IPF1/STF-1/IDX-1. The islet amyloid polypeptide (IAPP; amylin) gene, which is also expressed in limited tissues such as pancreatic β- and δ-cells, contained similar AT-rich sequences in its regulatory sequences. To understand the molecular basis of IAPP gene regulation, we evaluated the possible physiological significance of the motif in human IAPP gene regulation. All of the three typical A element-like sequences that matched the CT-box consensus (AT-1,-207/-202; AT-2,-154/-142; and AT-3,-88/-83) were shown to bind specifically to a nuclear factor in the β-cell-derived MIN6 cells, which was subsequently identified immunologically as the insulin gene transcription factor PDX-1. When the promoter activity was examined in MIN6 cells, the disruption of AT-1 or AT-3 but not of AT-2 caused a marked reduction in the IAPP gene promoter. Thus, despite the observation that all the three A element-like regions could bind to PDX-1, the AT-2 site may not be involved in mediating the PDX-1 actionin vivo.These observations suggest the involvement of PDX-1 in human IAPP gene regulation, which seems to be mediated through at least two A element-like cis-motifs in the gene promoter.

☆Abbreviations: IAPP, islet amyloid polypeptide; bp, base pair(s); PCR, polymerase chain reaction.
1Recipient of a fellowship and grant from the Japan Society for the Promotion of Science for Japanese Junior Scientists.
kajimoto@medone.med.osaka-u.ac .jp.
Copyright 1996 Academic Press. All rights reserved.

Transcriptional regulation of the IAPP gene in pancreatic β-cells2004, Biochimica et Biophysica Acta (BBA)- Gene Structure and Expression
Louisa M.A. Shepherd , Susan C. Campbell , Wendy M. Macfarlane PDF (339 K).

““You must not lose faith ”

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#306 Feb 1, 2013
Alzheimer and Diab. II are basicly about a proteine-lipid interaction.

http://www.ncbi.nlm.nih.gov/pubmed/15182369

Further reading for a better understanding.
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#307 Feb 1, 2013
Chimney1 wrote:
<quoted text>
But this prediction does not differentiate Sanford from standard evolution, which also predicts an increasing number of genetic diseases when natural selection is counteracted with medicine.
There is no medicine that counteracts against the increasing number of genetic diseases.

““You must not lose faith ”

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#308 Feb 1, 2013
APP undergoes rapid anterograde transport in neurons. During its transport, APP was found to interact with kinesin-I and functions as a kinesin-I membrane receptor to mediate axonal transport of &#946;-secretase (BACE1) and PS1 [26,27]. However, another study failed to verify the interaction between APP and kinesin-I and the co-transport of BACE1 and PS1 with APP [28]. We recently found that APP and its derived membrane-associated form, CTFs, can regulate cell surface delivery of PS1/&#947;-secretase but not BACE1 [29]. In addition, APP was found to be a major component of herpes simplex viral particles and likely mediates fast anterograde transport of these particles [30,31]. Another study showed that increased doses of APP markedly decreased retrograde transport of nerve growth factor and resulted in degeneration of forebrain cholinergic neurons in a mouse model of Down's Syndrome [32]. APP was also found to interact with high-affinity choline transporter (CHT) through the C-terminal domain and APP deficiency affected CHT endocytosis [33]. Overall, most studies suggest that APP plays some role in regulating protein trafficking.

Molecular Brain APP Processing in Alzheimer.
The APP gene is found on chromosome 21.
http://www.molecularbrain.com/content/4/1/3
beta ACE stands for splicing APP.

---
I would simply stay away from High Fructose and Glucose corn-sirup products. Made from mais, and added to just about all pre-prepared food and sweets, cereals a.s.o.
They have the same detrimental effect on the brain.->acidification that interrupts neural growth and connectivity.
And makes the body fat real fast.

If you wanted to duplicate the effects of DIAB.II and Alzheimer, you could not find a better way.

If APP is frankly a regulating mechanism (closely related hormonal enzym to insulin, that can in high dosage give rats anorexia.), it will try to counteract all the excess, but in doing so attracts co-location of proteins with fiber-proteins, or the toxic phase just before that.
And the key is probably hiding in the RNA (This was one for KittenKoder)

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#309 Feb 1, 2013
Shubee wrote:
<quoted text>There is no medicine that counteracts against the increasing number of genetic diseases.
How long have those genes been there...whut...they did not pop-up yesterday!
I do not understand why you can not understand the proper relation.
Nor methylation.
Or hormonal Alzheimer caused by an epigenetic, phenotypical disturbance that the body is not capable of dealing with.
Or environmental cocktails of toxins.
The Dude

Birkenhead, UK

#310 Feb 1, 2013
Shubee wrote:
<quoted text>There is no medicine that counteracts against the increasing number of genetic diseases.
This argument might be valid if all humans have acquired all genetic diseases simultaneously.
The Dude

Birkenhead, UK

#311 Feb 1, 2013
Shubee wrote:
<quoted text> Garbage in; garbage out. Why not start with a realist sense of fitness?
Note that if we were actually debating reality, we would begin by questioning how researchers decide which diseases originate from externalities like environmental pollutants versus genomic decay.
You have no basis for genomic decay as it relies on a so far undemonstrated ideal of Adam and Eve's genome, and ignores the fact that other organisms have an even greater genome difference than humans and seem to get by just fine. But still none of this matters when your god magically poofs things into existence at whim, hence you have no idea whether people are even suffering "genomic decay" or were simply magically poofed, uh, sorry, I mean "designed" - into existence that way by your god - whose existence and methods are ALSO undemonstrated. I pointed out this flaw to you days ago yet here you are still arguing from an undemonstrated premise.

Such is the nature of pseudo-scientific fundies such as yourself.
The Dude

Birkenhead, UK

#312 Feb 1, 2013
Shubee wrote:
<quoted text>Everyone understands fitness to mean health. Shouldn't we also include the absence of genetic diseases?
No, in your case your idea of "fitness" means a very specific genome configuration which you're unable to specify or demonstrate, hence vague references to genetic diseases. Unless every human is demonstrated to have every genetic disease ever, AND to the point that natural selection cannot overcome them thus reducing the current population as a whole, you got zip. This is why I'm still waiting for a specific date for genetic critical mass based on current mutation rates from which humanity will not be able to recover.

This must be the third Seventh Day Adventist Great Disappointment. As it seems to tie in with when Jesus is coming back.

“I Am No One Else”

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#313 Feb 1, 2013
Shubee wrote:
<quoted text>There is no medicine that counteracts against the increasing number of genetic diseases.
Did you skip his entire post? Because your response has nothing to do with what he said. Or are you using the strawman fallacy .... again.

““You must not lose faith ”

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#314 Feb 1, 2013
Recall the SHUBEE quote:
Dr. Pasinetti and his colleagues are optimistic that if they find that PGC-1 can be manipulated pharmacologically to prevent BACE accumulation in the brain, these studies will provide important insights for the formulation of novel treatments and possible preventative strategies in Alzheimer's disease.

PGC-1
A proliferator-activated receptor gamma coactivator-1
Short name: PGC-1 beta
or PPAR-gamma activator-1 beta
or PPARGC-1-beta

ALTERNATIVE MAME(S): PGC-1 RELATED ESTROGEN RECEPTOR
PGC-1- alpha has the same effect, but is also sold as a proteine to enhance muscles.

L.O.L.

So it's estrogen, the pill, or rather a combination, a boost so to say, but sold as a fancy gen, or expensive protein and I'll bet even more expensive medication.

So you can look for the protein pgc-1-alpha and it's price and take estrogen, and leave those corn-sugars alone and add more f.i. lentils or linseed (cheap option) or nuts and fish to your diet.
And do loose weight.
The Dude

Birkenhead, UK

#315 Feb 1, 2013
Shubee wrote:
<quoted text>I am very happy to acknowledge that my fellow Christian brother Dr. John C. Sanford was the first person to define devolution theory scientifically. However, I believe that I deserve the recognition of discovering devolution theory independently of Sanford and more importantly, that Im the first to axiomatize devolution theory. http://everythingimportant.org/genome.pdf
Devolution theory is certainly not refuted by noting the obvious and unquestionably uncontested fact that average population fitness initially increases if a sizable number of extremely defective machines do not reproduce.
So natural selection can overcome devolution even though natural selection can't overcome devolution. And just ignore the reality-denying young Earth apologetics.

But none of it matters since there really is no devolution as it's actually just the designer magically poofing each new life form into existence with increasingly less robustness. Devolution is therefore false.
The Dude

Birkenhead, UK

#316 Feb 1, 2013
Shubee wrote:
<quoted text>And as the number of new genetic diseases escalate, devolution theory will grow in acceptance to the point of being practically undeniable.
And so will creationism. Which appears to have suffered from devolution over the past three millenia.

OMG you're right! Devolution proved!!!

:-O

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#317 Feb 1, 2013
Jesus Christ was intelligently designed and here is the, two part, tale of just how it happened.....

http://www.youtube.com/watch...

)))((((((
(*)...(*)
....u....
____O____---{Oh my!}
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#318 Feb 1, 2013
The Dude wrote:
So natural selection can overcome devolution
No, natural selection can only slow down devolution.

““You must not lose faith ”

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#319 Feb 1, 2013
Shubee wrote:
<quoted text>No, natural selection can only slow down devolution.
AAAARRRGHH
And will you now please read all the scientific work and the line on human origin...so we can have a normal conversation.

“I Am No One Else”

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#320 Feb 1, 2013
MAAT wrote:
<quoted text>
AAAARRRGHH
And will you now please read all the scientific work and the line on human origin...so we can have a normal conversation.
WAIT! Hold the bus. Are you asking him to ....*gasp* learn something? Are you insane?

““You must not lose faith ”

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#321 Feb 1, 2013
Shubee wrote:
<quoted text>No, natural selection can only slow down devolution.
Your example on Alzheimer that was meant to be your proof, was nothing but a spiel, a marketing trick.
It'snot about a gene.

So do answer The DUDE's question,estimate,calculation, number of genes involved. Till we reach full stop and give birth to mud.

I just read about little arizona flies evolving proteases consisting if digestive enzymes and a coating in their tiny wombs and in their reproductive female tract, so they can store sperm.
Evolution that did not happen for 24 million years, but right here and now. Interrelational breeding with melanogasters and not just intra-group.

““You must not lose faith ”

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#322 Feb 1, 2013
KittenKoder wrote:
<quoted text>
WAIT! Hold the bus. Are you asking him to ....*gasp* learn something? Are you insane?
Nooo... cool as a vagina with teeth! YOMAMA.

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