I referred to your mentioning of a 20% similarity.I didn't include sugar metabolism because its receptor didn't show up there. BTW CCK receptor that influences hunger did shown on evolution tree. There are many hormones dealing with hunger.
If i found this connection 2 weeks ago then how could i have it published already in peer-reviewed place? What is there to review beside redoing BLAST search? Can't you at least accept similarities you all could recheck within 2 minutes?
You said something about this at least 20% similarity being known but then could you show it somewhere?
Point was partly you can discover new stuff through using BLAST search but finding that connection with program doesn't prove humans knew about. Imagine all the known genes and then imagine how many possible pairs of comparisons can be made between them. This number is astronomical but BLAST can find closest matches within minutes for 1 gene at time.
I found myself several times checking long list with correlations...forgot the site.
So usually i think in correlations and not percentages.
All i can think of is perusing the literature and published articles with any content that vaguely goes that way.
What i did find is that fat like ghrelin and leptin also delivers a signal. How? Good question.
So what is it that you actually established?
What are we looking at.