Possible connection i found between o...

Possible connection i found between opioid receptors and enjoiment of fatty food

Posted in the Evolution Debate Forum

First Prev
of 2
Next Last
Mhein

Tartu, Estonia

#1 Jul 8, 2012
Basically i compared public domain genome data using BLAST in NCBI (links in my site). Found out that several free fatty acid receptors (i didn`t add all to these evolution tree as they would get too crowded with names) were at least 20% identical to opioid and cannabinoid receptors. Also drinking about 1 gram of sunflower oil gave me pleasant buzz through body i`ve got with codeine. I wonder if i`m first to discover it or is that longer known thing. Maybe it would help people lose weight if they knew that they are kinda wired to enjoy fat similarly to opiates.
http://www.sidesofsentience.com/2012/07/about...
Mhein

Tartu, Estonia

#2 Jul 8, 2012
Define spam in this forum

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#3 Jul 9, 2012
Funny.
Peddling fat to control pain?
'Spam' can be used in several ways.
f.i. is this going anywhere"...or when the reply is not exactly relevant but not nonsense"
or when someone disagrees but not outspokenly'.
How it would link to the evolutionary tree would be the interesting bit.

Another theory is that cooking food makes it more nutricious, thus that helped develop our brains.

Given the comparison with codein.
Olive oil has known anti-inflammatory properties.
Research has been done in how fat, metabolism*, the hungercenter a.s.o. are linked to evolution of homo-sapiens.
And 20 % is an interesting number though the link was allready known.
Opiod receptors are not the same as cannabinoid receptors.
But it has virtually no effect on the pain-center. In general Cannabis is not supposed to have any effect on pain. It might relax people, if they are having that intention, but on the whole it just strenghtens whatever state people are in.

*Thin people have a slow metabolism, so less inclined to go hungry fast, so they eat less.
The feeling of being hungry is the same as craving a smoke. The body finds a way to express it.
Fat satisfies...it also gives energy fast.
It's also been found that if you would turn your meals in a pureed soup it would take longer to digest as in staying longer in the stomach, giving of slow energy, and in that way stave of appetite and mimicking the slow metabolism.
Mhein

Tartu, Estonia

#4 Jul 9, 2012
What peddling fat to control pain? I was critical of overuse of fat and i didn't write about its effect to pain.

Since: Jul 12

Location hidden

#5 Jul 9, 2012
Thin people consume somewhat less calories relative to their activeness than fatter people. Try do find me 1 article from pubmed central that says cannabis doesn't reduce pain.

How does puree absorb slower than something unchewed or intact?

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#6 Jul 9, 2012
Mhein wrote:
What peddling fat to control pain? I was critical of overuse of fat and i didn't write about its effect to pain.
You compared it's use to taking codein. It's effect to getting a buzz.
I stated the Pain-center.
And tests have shown cannabinoids do not work for pain in general.

Reverse the idea. it would mean that people taking cannabis and opiates would automatically loose weight.

No i'll not quote an article. i've looked into pain and the most effective ways to deal with it about two years ago. Including receptors and the case where opiates do not work. that would be the overactive pain-center.
i did notice that you thought your idea to have some merit for weight-control, but that is old news.
Find out how satiation works.
The Dude

Birkenhead, UK

#7 Jul 9, 2012
Mhein wrote:
Define spam in this forum
"Mhein"

Since: Jul 12

Location hidden

#8 Jul 9, 2012
I said opiates and cannabis both give munchies. How did you read it as reducing weight?

Also just because BLAST program can find connection between genome databases doesn't mean humans have known it.

BTW i feel opioids and cannabinoids start with satiation like buzz (i've tried both) but as they lose effects after receptor desensitizing then restless hunger starts maybe 2-4 hours after dosing.

Since: Jul 12

Location hidden

#9 Jul 9, 2012
If topix has most readers from small US towns like wiki says then it makes sense creationist type people start misreading important points or quietly try to remove it as spam.

“Transitional Molecular Fossils”

Since: Dec 06

Somewhere in Penn's Woods

#10 Jul 9, 2012
Post a link(s) to where your research has been published, other than your site. By whom was it peer-reviewed?

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#11 Jul 9, 2012
quote:
Basically i compared public domain genome data using BLAST in NCBI (links in my site). Found out that several free fatty acid receptors (i didn`t add all to these evolution tree as they would get too crowded with names) were at least 20% identical to opioid and cannabinoid receptors. Also drinking about 1 gram of sunflower oil gave me pleasant buzz through body i`ve got with codeine. I wonder if i`m first to discover it or is that longer known thing. Maybe it would help people lose weight if they knew that they are kinda wired to enjoy fat similarly to opiates.
http://www.sidesofsentience.com/2012/07/about ...

What peddling fat to control pain? I was critical of overuse of fat and i didn't write about its effect to pain.

I said opiates and cannabis both give munchies. How did you read it as reducing weight?

BTW i feel opioids and cannabinoids start with satiation like buzz (i've tried both) but as they lose effects after receptor desensitizing then restless hunger starts maybe 2-4 hours after dosing.
---
the only question left would be, if you got the munchies after taking 1 gram of sunflower-oil?

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#12 Jul 9, 2012
http://www.gnolls.org/tag/what-is-hunger/
lot's of references to all sorts of related findings.
Shocking: once you have been obese you have reduced the efficience of energy-use of your body permanently!

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#13 Jul 9, 2012
Ghrelin see site former post.
leptin discussed near bottom of page:
http://www.psychology4a.com/eating%20behaviou...

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#14 Jul 9, 2012
Katydid wrote:
Post a link(s) to where your research has been published, other than your site. By whom was it peer-reviewed?
i also miss proper test conditions, test-group, neutral, etc.

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#15 Jul 9, 2012

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#16 Jul 9, 2012
Ironically though, the lard would actually be more healthful for you than the soda!

Fructose simultaneously prevents weight loss and promotes fat storage, by:

■Diminishing your satiety (feelings of fullness) as it does not stimulate a rise in leptin, one of the most powerful hunger and fat storage regulators in your body. And, of course, when you're feeling hungry you tend to eat more.
Leptin resistance, just like insulin resistance, is also one of the most significant factors underlying a vast array of diseases. For example, it plays a significant if not primary role in the development of heart disease, obesity, diabetes, osteoporosis, autoimmune diseases, reproductive disorders, and perhaps the rate of aging itself.

■Not suppressing ghrelin (also known as "the hunger hormone"). Glucose, on the other hand, does suppress ghrelin, making you feel satiated
■Slowly, if consumed chronically, causing insulin resistance, which hampers weight loss efforts
■Converting directly to fat more readily than any other sugar. It is also known to raise triglycerides significantly
■Robbing your body of micronutrients while assimilating itself for use (in the case of foods containing high fructose corn syrup. Whole fruits on the other hand does not have this particular problem as the fruit contains all these extra nutrients along with the fructose)
With all these simultaneous factors coming into play every time you consume fructose, it's easy to see why a high-fructose diet can propel you into a vicious cycle of over-eating while also being malnourished.

My recommendation is to keep your total fructose intake below 25 grams of fructose per day, if you're in good health. Most people will also benefit from limiting your fructose from fruit to 15 grams a day, and, if you need to lose weight, you likely will need to limit your total fructose consumption to 15 grams a day total, including that from fruit.

---
Sugar made from mais does have no specific taste, so it is added to a lot of foods, especially kid-foods.
Recently they also found a link with reduced IQ through eating this a lot.
High Fructose Corn Syrup (HFCS)
Research by David Geffen School of Medicine.
High fructose rats navigated worse through a maze.

A third group got omega 3 as found in fatty fish and linseed-oil, They performed the best.

The key would be docosahexaeen-acid, which improves brainsynaptic conductivity, necessary for a good memory.
We do not make suffient amounts of it so have to get it from food intake.
Omega-3 is however broken down by fructose-syrup!
----
Well that's just about the big frame.
So how does Mhein's research fit the picture?

““You must not lose faith ”

Level 5

Since: Jun 11

Location hidden

#17 Jul 9, 2012
In ths thread it's presented clearly and well-sourced.
Best option for making a connection imo.
http://forum.lowcarber.org/showthread.php...

Since: Jul 12

Location hidden

#18 Jul 9, 2012
I didn't include sugar metabolism because its receptor didn't show up there. BTW CCK receptor that influences hunger did shown on evolution tree. There are many hormones dealing with hunger.
If i found this connection 2 weeks ago then how could i have it published already in peer-reviewed place? What is there to review beside redoing BLAST search? Can't you at least accept similarities you all could recheck within 2 minutes?

You said something about this at least 20% similarity being known but then could you show it somewhere?
Point was partly you can discover new stuff through using BLAST search but finding that connection with program doesn't prove humans knew about. Imagine all the known genes and then imagine how many possible pairs of comparisons can be made between them. This number is astronomical but BLAST can find closest matches within minutes for 1 gene at time.

Since: Jul 12

Location hidden

#19 Jul 9, 2012
BTW i did cite pubmed articles about how blood coagulation can be reduced with omega fatty acids and by some others.
Several blood coagulation receptors showed up along with blood pressure regulating receptors and guess if obese people have more heart or cardiovascular problems.

I included hypothesis that it would help reduce blood viscosity. And also why opiate withdrawal might cause intestinal cramps or vomiting.

Since: Jul 12

Location hidden

#20 Jul 9, 2012
I don't have job in lab although i almost have masters degree in molecular biology. Instead of my own animal experiments i use several studies that studied effects of fat on coagulation and mood.
For example blocked opioid receptors cause craving for fatty food ( http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2... ).
These connections keep making sense if i presume all these related receptors activate and stop working at same time.

@ MAAT Prove that "Omega-3 is however broken down by fructose-syrup!" actually is like that. Also what law of physics makes puree slower to absorb then barely chewed food?

Tell me when this thread is updated:

Subscribe Now Add to my Tracker
First Prev
of 2
Next Last

Add your comments below

Characters left: 4000

Please note by submitting this form you acknowledge that you have read the Terms of Service and the comment you are posting is in compliance with such terms. Be polite. Inappropriate posts may be removed by the moderator. Send us your feedback.

Evolution Debate Discussions

Title Updated Last By Comments
News Evolution vs. Creation (Jul '11) 13 min DanFromSmithville 168,771
News Aliens and evolution (Jun '12) 3 hr dirtclod 6,213
News "Science vs. Religion: What Scientists Really T... (Jan '12) 4 hr Chimney1 19,766
News It's the Darwin crowd that lacks the facts in e... (Mar '09) 20 hr Paul Porter1 141,815
How can we prove God exists, or does not? Thu Paul Porter1 197
How would creationists explain... (Nov '14) Thu Paul Porter1 561
three preventive measures for PID Thu qiu 1
More from around the web