Honey, I could have posted the abstract because I sourced the link. Clearly that link speaks to the accumulation of deleterious mutations because the effectiveness of natural selection has declined.Does ths article state that the human genome is irrevocably down the drain, Mazhere?
What is the gain for humans?
What is it ofset to?
Although sequences containing regulatory elements located close to protein-coding genes are often only weakly conserved during evolution, comparisons of rodent genomes have implied that these sequences are subject to some selective constraints. Evolutionary conservation is particularly apparent upstream of coding sequences and in first introns, regions that are enriched for regulatory elements. By comparing the human and chimpanzee genomes, we show here that there is almost no evidence for conservation in these regions in hominids. Furthermore, we show that gene expression is diverging more rapidly in hominids than in murids per unit of neutral sequence divergence. By combining data on polymorphism levels in human noncoding DNA and the corresponding human–chimpanzee divergence, we show that the proportion of adaptive substitutions in these regions in hominids is very low. It therefore seems likely that the lack of conservation and increased rate of gene expression divergence are caused by a reduction in the effectiveness of natural selection against deleterious mutations because of the low effective population sizes of hominids. This has resulted in the accumulation of a large number of deleterious mutations in sequences containing gene control elements and hence a widespread degradation of the genome during the evolution of humans and chimpanzees.
Citation: Keightley PD, Lercher MJ, Eyre-Walker A (2005) Evidence for Widespread Degradation of Gene Control Regions in Hominid Genomes. PLoS Biol 3(2): e42. doi:10.1371/journal.pbio.00300 42
reading is a skill.
"likely that the lack of conservation and increased rate of gene expression divergence are caused by a reduction in the effectiveness of natural selection against deleterious mutations because of the low effective population sizes of hominids."
Did you notice the word LIKELY? In actual fact researchers have no idea what the population size was at any time in the ancient past. They use what suites them. So in the end this research provides data that the homonid genome is deteriorating through the accumulation of deleterious muations and they offer an evolutionary get out of a falsification for free card by offering a possible scenarion.
The problem is I have provided multiple examples of deteriorating genomes and I can provide a plethora more....
..... AND I was talking to KAB in support.
That is not my discussion. KAB can handle you lot running around like lunatics going from one topic to another and not concluding any point. Talk to him. He wraps you lot up in foil and bakes you very easily.
If you lot cannot offer a reply then I will take the point as being established. Placental mammals are dated to 245mya and falsify the current evolutionary mess that isn't evidence for anything, and provides support for Devonian cetaceans!