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Level 5
Since: Mar 12
Dubai, UAE
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Russell wrote: <quoted text> E coli have a whole suite ---an operon---to confer citrate fermenting ability. They already possess the ability to "digest" citrate, but only under certain circumstances. We have been through this before.... Short attention span? Too close to bedtime? Lenski himself stated, " A more likely possibility, in our view, is that an existing transporter has been co-opted for citrate transport under high oxic conditions" Also see, in regards to the transporter: Pos, K M, Dimroth, P and Bott, M, "The Escherichia coli Citrate Carrier CitT: a member of a novel eubacterial transporter family related to the 2-oxoglutarate/Malate translocator from Spinach chloroplasts, J Bacteriol 180(16):4160-4165, 1998. www.pubmedcentral.nih.gov/articlerender.fcgi... This transporter is only activated under oxygen free conditions with good reason. But you will never know the reason..... Co-opting and elaboration of existing systems is evolution. The ability to digest citrate required a modification of existing systems and occurred through two separate mutations occurring thousands of generations apart, the first being apparently neutral until the second occurred.
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Level 5
Since: Mar 12
Dubai, UAE
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Russell wrote: This transporter is only activated under oxygen free conditions with good reason. "Good reasons" that are obviously absent in the environmental conditions of the Lenski experiment. Hence the adaptation. Now, once again, please present your argument as to why adaptation should not be a continual and open ended process? The distinction between adaptation and evolution raised by creationists is an artificial one. Evolution is simply adaptation occurring over long periods of time. Don't tell me...you're a YEC.
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Mugwump
London, UK
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The Dude wrote: <quoted text> And for reference, here is that thread. Where Russ starts out lying from the very first post: http://www.topix.com/forum/news/evolution/TMH... Despite his many mistakes he's not conceded a single one. Cheers dude - for some reason that thread only showed up on my phone, not on the tablet - hence could go back and fact check the details of the nonsense. Strange that creationists never fess up to lying - thought there should be a commandment about it personally.
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Level 5
Since: Mar 12
Dubai, UAE
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Subduction Zone wrote: <quoted text> You are conflating unsupported bullshit by creatards with debunking. And once again, the laboratory test of E. coli that evolved the ability to digest citrate was not adaptation. The inability of E. coli to digest citrate is well known. In fact during the test they took these precaution to make sure that it was NOT adaptation: <quoted text> http://en.wikipedia.org/wiki/E._coli_long-ter... Now you can make all of the unsupported creatard "adaptation" claims that you want. In this case we know that you are wrong. Wait a sec, lets get our terms straight. Developing the ability to digest citrate was an adaptation. All evolution is adaptation (with the exception of drift). Evolution is just a load of adaptation, iteration after iteration, with new variation entering via mutations and selected for, or against, by survival and reproductive fitness. What I want to hear is Russell's explanation of how he thinks this process somehow stops at some point, because if it dos not, that IS evolution!
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Russell
Adelaide, Australia
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Chimney1 wrote: <quoted text> Wait a sec, lets get our terms straight. Developing the ability to digest citrate was an adaptation. All evolution is adaptation (with the exception of drift). Evolution is just a load of adaptation, iteration after iteration, with new variation entering via mutations and selected for, or against, by survival and reproductive fitness. What I want to hear is Russell's explanation of how he thinks this process somehow stops at some point, because if it dos not, that IS evolution! Monod and Jacob must be turning in their graves.... Anyhoo... This is all covered ground... Just ask the Dude while he sits in a corner, cradling SETMAR, gentle rocking back and forth, saying, "I like you SETMAR. You're not all useless for evolutionary causes...I still like you...." No mate. Adaptation is not evolution. Lenski started with an organism with a complete genome. Reasonable to suggest that the transporter gene suffered a mutation. May have been neutral. A second mutation may have...who knows, converted the tartrate transporter to start transporting citrate even with oxygen present? Who knows really.... However, evolution it ain't. Citrate transportation is energy hungry. Therefore reserved only for special occasions where anaerobic respiration, less efficient, is needed. It benefits the organism to have this switched off in times of oxygen replete-ness A mutation ruining this status quo, eg no citrate uptake unless absolutely needed...is not beneficial. By the way, the generations needed to achieve just two mutations was 20,000. This is with huge numbers with short generation times...the mutations were barely achievable.... What does this say for human or mammalian evolution? This has all been covered before... I get the feeling that you view, as SubDud does, life as a huge overturned bowl of Jelly, with DNA amd RNA darting around ferociously mutating wildly and producing....well, er....design... No Bud, that just does not work. What else you got?
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Russell
Adelaide, Australia
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Mugwump wrote: <quoted text> Cheers dude - for some reason that thread only showed up on my phone, not on the tablet - hence could go back and fact check the details of the nonsense. Strange that creationists never fess up to lying - thought there should be a commandment about it personally. C'mon Mugwump Stop being such a baby What else you got? You're stuck on 1000's base pairs and nothing can budge you! Pretty stubborn creature? By the way, have you met Prof Andy McIntosh? Much beloved by creationists and despised by the Dude? I think the Dude is just jealous since HE has no thermodynamic credentials.... Nothing to be jealous of, the Dude.... You too could be a Christian and Creationist one day, just like good ol' Prof
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Russell
Adelaide, Australia
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Chimney1 wrote: <quoted text> "Good reasons" that are obviously absent in the environmental conditions of the Lenski experiment. Hence the adaptation. Now, once again, please present your argument as to why adaptation should not be a continual and open ended process? The distinction between adaptation and evolution raised by creationists is an artificial one. Evolution is simply adaptation occurring over long periods of time. Don't tell me...you're a YEC. Here's my original post from a sister thread: http://www.topix.com/forum/news/evolution/TMH... Number 609 "PART 4 All this sounds great to an evolutionist. Until, enter Stage Left, operons. Thus the changes were not independent at all, but due to a change in just one control gene. A regulatory gene called spoT. The cost of the changes were that the energetically costly genes that make the bacterial flagellum were switched off. So, as is quite obvious, this experiment showed nothing but information reducing change. Deterioration. Proof of this was that none of the tribes could utilize ribose anymore and some lost their DNA repair ability. These poor pampered bugs could not compete with the wild types outside the environment of the lab. "A very clever man said this,“Chemicals obey the second Law of Thermodynamics and do not arrange themselves into self sustaining metabolic pathways. "Living cells have molecular machinery, whose assembly is directed by programmed instructions, to channel the chemistry in the right direction and amounts.” This brings me to Lenski’s citrate-using E coli. Rather than labour this point, suffice to say, utilising citrate is not Climbing Mount Improbable for bacteria. The Kreb’s cycle , aka Citric acid cycle, can occur in anaerobic conditions. The reason that this mutation to enable one tribe to utilise citrate, similar to chloroquine resistance, did not occur in the other tribes, was perhaps due to the requirement for more than one mutation. Difficult to achieve. Even this experiment neatly illustrates the difficulty with obtaining two mutations, even with thousands of generations and a massive population, a new function requiring two mutations was barely obtainable. Three would have been unreachable. E coli have a whole suite of genes, an operon, able to ferment citrate, including a citrate transporter gene that codes for a transporter protein that embeds in the cell wall. This operon is activated under low oxic conditions, as anaerobic respiration is less efficient than aerobic, so there is good reason for this to be switched off unless O2 is lacking. But, the Lenski citrate E coli demonstrated a lack of regulation, so it’s a downhill change. Lost specificity. So citrate-transporter-regulation damaged by mutation remains permanently switched on regardless of the oxygen state. A fault in this system. Also a tartrate transporter may have lost specificity and started to take up citrate." End of my old quote. You don't have to agree with everything.... You are allowed to have your views Just appreciate that we have all previously covered a lot of ground. So don't be astonished if I don't fall over backwards in amazement by what you have to say. Although I am ever hopeful...
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Mugwump
London, UK
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Russell wrote: <quoted text> C'mon Mugwump Stop being such a baby What else you got? You're stuck on 1000's base pairs and nothing can budge you! Pretty stubborn creature? By the way, have you met Prof Andy McIntosh? Much beloved by creationists and despised by the Dude? I think the Dude is just jealous since HE has no thermodynamic credentials.... Nothing to be jealous of, the Dude.... You too could be a Christian and Creationist one day, just like good ol' Prof As mentioned, I recalled what you said incorrectly - but the point still stands - you presented a straw-man of Abiogenesis - namely that life started with a cell that coded for 1000s of proteins. But failed to present a reference for where science claims this. Seems straightforward to me
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Russell
Adelaide, Australia
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Mugwump wrote: <quoted text> As mentioned, I recalled what you said incorrectly - but the point still stands - you presented a straw-man of Abiogenesis - namely that life started with a cell that coded for 1000s of proteins. But failed to present a reference for where science claims this. Seems straightforward to me You really are stuck... Try this on for size: http://www.gizmag.com/first-synthetic-organis...
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Russell
Adelaide, Australia
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Mugwump wrote: <quoted text> As mentioned, I recalled what you said incorrectly - but the point still stands - you presented a straw-man of Abiogenesis - namely that life started with a cell that coded for 1000s of proteins. But failed to present a reference for where science claims this. Seems straightforward to me For your reading pleasure: http://creation.com/chemical-soup-is-not-your... and also by Dr Aw Swee-Eng http://creation.com/origin-of-life-critique
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“Aut Pax Aut Bellum”
Level 5
Since: Nov 10
Leyland (or close enough)
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appleboy wrote: <quoted text> I've always thought that there were mudering bastards on both sides. Some folks who grow up in war learn to love it. But at some point, in order to stop the carnage, the leaders must learn to shake hands and go home. That does not stop the hurt of the people those leaders have caused to be injured or maimed. Or the hurt of those whose loved ones have been murdered on either side. The difference is that those protecting unionism in what is after all a predominantly “unionist” environment did not deliberately and arbitrarily target innocent children and unarmed civilians
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Level 5
Since: Mar 12
Dubai, UAE
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Russell wrote: <quoted text> Monod and Jacob must be turning in their graves.... Anyhoo... This is all covered ground... Just ask the Dude while he sits in a corner, cradling SETMAR, gentle rocking back and forth, saying, "I like you SETMAR. You're not all useless for evolutionary causes...I still like you...." No mate. Adaptation is not evolution. Lenski started with an organism with a complete genome. Reasonable to suggest that the transporter gene suffered a mutation. May have been neutral. A second mutation may have...who knows, converted the tartrate transporter to start transporting citrate even with oxygen present? Who knows really.... However, evolution it ain't. Citrate transportation is energy hungry. Therefore reserved only for special occasions where anaerobic respiration, less efficient, is needed. It benefits the organism to have this switched off in times of oxygen replete-ness A mutation ruining this status quo, eg no citrate uptake unless absolutely needed...is not beneficial. By the way, the generations needed to achieve just two mutations was 20,000. This is with huge numbers with short generation times...the mutations were barely achievable.... What does this say for human or mammalian evolution? This has all been covered before... I get the feeling that you view, as SubDud does, life as a huge overturned bowl of Jelly, with DNA amd RNA darting around ferociously mutating wildly and producing....well, er....design... No Bud, that just does not work. What else you got? There were 12 flasks in Lenski's experiment, and all of them adapted to the environment given and showed population increases over time as they adapted. Just as we would expect in the evolution / adaptation paradigm. And while all of them came from a monoclonal starting culture, the specific adaptations and mutations involved in every flask were different. The famous citrate-eater flask was an unexpected bonus. Adaptation is not evolution? Perhaps, in the same way that driving a mile a mile is not a trip across America, but evolution is nothing but adaptation continued. You now have to explain what effect exists that you think prevents adaptation from continuing indefinitely, especially in environments that are not as stable as provided in the Lenski experiment. What is this magic wall that you IDers are so sure has to exist?
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One way or another
Orlando, FL
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Russell wrote: <quoted text> You really are stuck... Try this on for size: http://www.gizmag.com/first-synthetic-organis... It must end badly, for what has man made or contrived, that has not been abused? What is released in nature will find its way into man and mutate.
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“Pissing people off since 1949”
Level 8
Since: Apr 08
Tampa, FL
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HTS wrote: <quoted text>I don't have a scientific survey. I know that the majority of physicians I know think goo-to-you evolution is absurd. Any survey that you can site will invariably fail to define "evolution". So you're full of crap then. Thanks ever so much for clearing that up.
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Level 5
Since: Mar 12
Dubai, UAE
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Russell wrote: <quoted text> Here's my original post from a sister thread: http://www.topix.com/forum/news/evolution/TMH... Number 609 ....So, as is quite obvious, this experiment showed nothing but information reducing change. Deterioration. Proof of this was that none of the tribes could utilize ribose anymore and some lost their DNA repair ability. These poor pampered bugs could not compete with the wild types outside the environment of the lab. "A very clever man said this,“Chemicals obey the second Law of Thermodynamics and do not arrange themselves into self sustaining metabolic pathways. "Living cells have molecular machinery, whose assembly is directed by programmed instructions, to channel the chemistry in the right direction and amounts.” This brings me to Lenski’s citrate-using E coli. Rather than labour this point, suffice to say, utilising citrate is not Climbing Mount Improbable for bacteria.... Even this experiment neatly illustrates the difficulty with obtaining two mutations, even with thousands of generations and a massive population, a new function requiring two mutations was barely obtainable.... End of my old quote. You don't have to agree with everything.... You are allowed to have your views Well, I will grant that you argue better than most ID/creationists. More generally, you are making the argument that adaptation involves a loss of function and adapted organisms are weaker than their wild cousins. Yes, often, but not always. "Kassen and Bataillon (2006) took a wild-type Pseudomonas flourescens bacterium, and exposed it to an antibiotic. They obtained over 600 antibiotic-resistant strains, with an estimated frequency of 2.4 x 10-9 beneficial mutations per cell division....These antibiotic-resistant strains were much fitter in the new environment than the parent wild-type bacteria, which could not survive at all in the presence of the antibiotic. Interestingly, even in the absence of antibiotic, at least 2.7% of the mutants were superior to the wild-type." Nature Genetics 38, 484 – 488 (2006) Rees Kassen and Thomas Bataillon Abstract: http://www.nature.com/ng/journal/v38/n4/abs/n... Of course, the bacteria are adapting to the environment they are in so one would expect them to become less well adapted to the original wild environment anyway. But the fact that some do better falsifies the assertion that adaptation causes a general loss of fitness. There are also documented benefits from gene duplication events which show that information can be "created" and provide novel material for further evolutionary development. And pulease, don't give us the old 2nd Law canard. If that version of the second law held, snowflakes and glaciers would be impossible. In an energy flux, localised spontaneous reduction of entropy is not an issue in physics.
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Level 5
Since: Mar 12
Dubai, UAE
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Russell wrote: For yours: [19]:“One example of a beneficial mutation comes from the mosquito Culex pipiens. In this organism, a gene that was involved with breaking down organophosphates – common insecticide ingredients -became duplicated. Progeny of the organism with this mutation quickly swept across the worldwide mosquito population.” Further details on this mutation are available [44]. It involves multiple duplications of two genes that generate carboxylesterases. As with the two examples below, gene duplication gave increased expression of certain enzyme(s), which increased the fitness of the organism. Natural selection would then favor the retention of the additional genes. http://letterstocreationists.wordpress.com/st...
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Mugwump
London, UK
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Russell wrote: No what you have linked to is a creationist site that presents the strawman that the first life consisted of a fully formed complex cell that coded for 1000s of proteins. What you meant to post I am sure is where science states this is the case. Fancy another try ?
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LowellGuy
Lowell, MA
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Judged:
1
Russell wrote: <quoted text> Monod and Jacob must be turning in their graves.... Anyhoo... This is all covered ground... Just ask the Dude while he sits in a corner, cradling SETMAR, gentle rocking back and forth, saying, "I like you SETMAR. You're not all useless for evolutionary causes...I still like you...." No mate. Adaptation is not evolution. Lenski started with an organism with a complete genome. Reasonable to suggest that the transporter gene suffered a mutation. May have been neutral. A second mutation may have...who knows, converted the tartrate transporter to start transporting citrate even with oxygen present? Who knows really.... However, evolution it ain't. Citrate transportation is energy hungry. Therefore reserved only for special occasions where anaerobic respiration, less efficient, is needed. It benefits the organism to have this switched off in times of oxygen replete-ness A mutation ruining this status quo, eg no citrate uptake unless absolutely needed...is not beneficial. By the way, the generations needed to achieve just two mutations was 20,000. This is with huge numbers with short generation times...the mutations were barely achievable.... What does this say for human or mammalian evolution? This has all been covered before... I get the feeling that you view, as SubDud does, life as a huge overturned bowl of Jelly, with DNA amd RNA darting around ferociously mutating wildly and producing....well, er....design... No Bud, that just does not work. What else you got? So, it's not evolution; it's just a genetic mutation that conferred a survival advantage and was thus spread through the population. The frequency of expression of the allele responsible for the survival advantage changed in the population over time, but it wasn't evolution. You do realize that this is the definition of evolution, don't you?
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LowellGuy
Lowell, MA
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Russell wrote: Creation.com : science :: Snoop Dogg : just say no
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“What, me worry?”
Since: Mar 09
I'm a racist caricature!
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Urban Cowboy wrote: <quoted text> We admit a duality of religion and science. You misrepresent ideology and history as "science", i.e., you guys are the ones at fault - not us. When you have to make up your own "science," you've stopped doing science. Tell us again about all the actual research being done by ICR and DI. Tell us about the experiments they're doing, and the innovations and technologies that are being derived from their research. You have yet to cite a single innovation or technology stemming from creationism. It's been months. You've certainly had plenty of time to find one. No luck thus far? Shocking.
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