Haldane (1957) calculated that it would take 300 generations to select a single new mutation to fixation. This is called Haldane's dilemma because it is too slow for any macroevolution to be feasible. At this rate you can only fix 1,000 unlinked nucleotide mutations in 6 million years, the supposed time humans diverged from chimps.
This simple fact was confirmed by Crow and Kimura (1970) and ReMine (1993,2005). This is less information than is in this comment (if it were 333 characters long). There is no way possible for this tiny amount of information to turn an ape into a human. And this is only for independent, unlinked mutations. Selection for 1,000 specific and adjancent mutations could not arise in 6 billion years. And the more nucleotides under selection, the slower the progress.
We know that man and chimp differ by about 150 million nucleotide positions due to at least 40 million hypothetical mutations (Britten, 2002). Therefore if man evolved from ape, there must have been 20 million nucleotide fixations. But natural selection could only account for 1,000, that means all the rest must have been fixed by genetic drift. That's 19,999,000 deleterious mutations and 1,000 beneficial ones, which of course would obviously have killed us.
This is based on Sanford's Genetic Entropy, Pages 128-130.
Haldane's Dilemma refers to a limit on the speed of beneficial evolution, first calculated by J. B. S. Haldane in 1957, and clarified further by later commentators. Creationists, and proponents of intelligent design in particular, claim it remains unresolved. Contrary to creationist claims, Haldane's dilemma is of no importance in the evolutionary genetics literature. Today, Haldane's Dilemma is raised mostly by creationists opposed to evolution, who claim it is evidence against large-scale evolution, and a supposed example of negligence on the part of the scientific community.
Were do you dredge up these old tired tidbits from yesteryear?
Haldane stated at the time of publication "I am quite aware that my conclusions will probably need drastic revision", and subsequent corrected calculations found that the cost disappears. He had made an invalid simplifying assumption which negated his assumption of constant population size, and had also incorrectly assumed that two mutations would take twice as long to reach fixation as one, while sexual recombination means that two can be selected simultaneously so that both reach fixation more quickly. The creationist claim is based on further errors and invalid assumptions.
Game, set, match, tennis!