Pfizera s Sutent is Recommended as Fi...

Pfizera s Sutent is Recommended as First-Line Treatment for Kidney...

There are 5 comments on the Earth Times story from Feb 4, 2009, titled Pfizera s Sutent is Recommended as First-Line Treatment for Kidney.... In it, Earth Times reports that:

Pfizer Inc said today that the United Kingdom's National Institute for Health and Clinical Excellence has issued its final appraisal document recommending the use of Sutent as a first-line treatment for ...

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Since: Dec 05

Union, NJ

#1 Feb 4, 2009
The short term future of cancer therapeutics is combinations of targeted drugs. Sutent could be one of those miracle targeted drugs. It is a "multi-targeted" kinase inhibitor. That means it inhibits several proteins involved in triggering replication in cancer cells.

Until Sutent, you had to take one type of drug for anti-tumor effects of human neoplasms, and another drug for anti-microvascular effects. With Sutent, multiple proteins are involved in both tumor proliferation (growth) and angiogenesis (blood vessels feeding a tumor). It has has both "anti-tumor" as well as "anti-angiogenic" properties. In addition, because it inhibits "multiple" kinases, it possesses activity against "multiple" types of tumors.

Sutent may directly bind to one of the proteins (VEGF) to directly inhibit angiogenesis (microvasculature regression). Within 24 hours of VEGF inhibition, endothelial cells have been shown to shrivel, retract, fragment and die by apoptosis (cell death). VEGF can cut off the supply of vessels that spring up to feed a tumor (angiogenesis).

How many days will Sutent take to respond on the tumors? No one really knows without testing the tumor first. Does the drug enter the cell? Once entered, does it immediately get metabolized of pumped out, or does it accumulate?

If, by testing the tumor first, Sutent is "synergistic" (cooperative) to cancer cells, it could be a miracle drug. It will not cure, but it can prolong survival for some time (like the cronic diseases).

Profiling the function of tumor cells can measure the net effect of everything which goes on (the entire genome of a cancer cell). It can look at both the anti-tumor and anti-microvascular effects of cancer drugs. Are the cells ultimately killed, or aren't they?
Harry

Albany, NY

#2 Jun 29, 2011
Reduced cost Brand Sutent, [email protected]
HIRA AKMAL

Lahore, Pakistan

#3 Sep 8, 2011
mery papa ko cancer ho gya ha wo sutent ues ker rehyn hn wo jald he teak ho jyn gy na
FBOMBER

Winnipeg, Canada

#4 Sep 8, 2011
Funny how every drug is called a miracle drug when someone is "pushing" it. A year or two later there's a class action lawsuit filed.
Wendy

Tel Aviv, Israel

#5 Nov 4, 2013
Hello, my mother have Kidney cancer ,the doctor said that he need to take Sutent medication. can some one advice me where is the best place to buy this medication?
Thank you

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