Study sheds light on angiogenesis inhibitors, points to limitations, solutions
A new generation of cancer drugs designed to starve tumors of their blood supply - called "angiogenesis inhibitors"--succeeds at first, but then promotes more invasive cancer growth-sometimes with a higher ...
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Since: Dec 05
#1 Mar 7, 2009
The benefits of the newer targeted therapies are marginal. They may impart a clinical benefit by stabilizing tumors, rather than shrinking them (substituting shrinkage for stabilization).
VEGF just happens to be one molecule which has been implicated in the process of angiogenesis, but there may be more.
If it were the only protein involved, then one would expect that VEGF expression would correlate with Avastin activity 100% of the time but it actually does so only about 20% of the time.
The presence of receptors to a specific antigen, which only "implies" dependence upon that antigen, a cell profile can actually assess the direct or indirect effect of the drug upon the cell, whether it is a tumor cell or an endothelial cell.
It doesn't just focus on VEGF or any one protein or mechanism. Whether it's VEGF alone (unlikely) or in combination with other proteins and other mechanical factors, the profile works by assessing the net effect of all those factors.
#2 Sep 23, 2013
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