Biomarkers for deciding a medication ...

Biomarkers for deciding a medication in a myocardial infarction patient

Posted in the Cardiology Forum

Sciclips

Madison, WI

#1 Sep 2, 2011
This US patent application describes a method of deciding which treatment or combination of treatments is to be applied in a remodeling process of a patient after a myocardial infarction. The method consist of determining an amount of a natriuretic peptide, a cardiac troponin, and an inflammatory marker in a sample from the patient, and initiating a remodeling in the subject, wherein a medication to be applied in the remodeling is selected according to the level of the peptide, troponin, and marker determined. An amount of NT-proBNP of 300 pg/ml is indicative of administering a medication selected from the group consisting of beta blockers, natriuretics, loop diuretics, nitrates, and positive inotropic agents. An amount of GDF-15 800 pg/ml is indicative of administering a medication selected from the group consisting of ACE inhibitors, angiotensin receptor antagonists, statins; NSAIDS, and selective COX-2 inhibitors. An amount of CRP-15>3 pg/ml is indicative of administering a medication selected from the group consisting of statins. An amount of osteopontin >500 pg/ml is indicative of administering a medication selected from the group consisting of anti-inflammatory drugs, angiotensin receptor antagonists, and aldosterone antagonists. News link: http://www.sciclips.com/sciclips/biomarker-ne...

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