In elderly men with prostate cancer o...

In elderly men with prostate cancer on Zoladex treatment, what is the ...

There are 15 comments on the NLH Question Answering Service story from Oct 25, 2007, titled In elderly men with prostate cancer on Zoladex treatment, what is the .... In it, NLH Question Answering Service reports that:

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Yheodore

Shanghai, China

#1 Dec 18, 2007
I'm a PCa patient of 74 age, using Zoladex. now. I adopt the intermittent therapy.My first treat cycle is rather successful, it lasts about 20 months. After injection about 7 monts, thwn I have had a lenitive stage of 12months. As my understanding , the length of the lenitive stage is determined by the rate of increment of antrogen, but not the rate of tumer growth. Since in the early of this stage, the hormone level is still low thus couldn’t nurture the tume. Thus I consider after the continuous injection of Zoladex is stopped,, one could using some single supplementary injection of a small dosage of Zoladex to control the antrogen on a suitable leve.l Pls tell me if it is feasible?
beer1

Petah Tiqwa, Israel

#2 Dec 20, 2007
Yheodore,
You need to know yore PSA. When your PSA goes up you need to go back to Hormonale treatment.
It is also a good practice to measure your Testosteron (T) level. When your T is low (Below 1 nmol/l) there is no need to get the Zoladex injection.
Itzhak
Nancy

Ottawa, Canada

#3 Jan 9, 2008
Hi,
My father has a prostate cancer at early stage. He has received his second injection of zoladex a month ago and is not doing good at all. He has leg pains to the point that he can't walk. It has been like that for a week and he is undergoing tests at the hospital. He is also feeling numbness in the face and a hand. We are extremely worried. Has anyone experienced those kind of symptoms?
Beth

Medina, OH

#5 Mar 20, 2008
My grandpa is a survivor of prostate cancer, and has been on zoladex for 18 years, is this harmful?
9438 KBS

London, UK

#6 Jun 26, 2011
I had radical prostatectomy in 2001 for locally advanced Ca Prostate. Soon after that I have had Zoladex injections every 12 weeks. My PSA after surgery has always been between 0.01- 0.04. Should I now stop Zoladex or use it intermittently ?
The opinions on this matter vary so much. May I have your thoughts on this matter. Thank you.
Ana M

Torrance, CA

#7 Jul 15, 2011
My grandfather has been diagnosed with prostate cancer. We are about to start this treatment. I hope this is going to help him ease the pain and make his life better. http://www.hiprecalllaw.com
Raymond

Torrance, CA

#8 Jul 21, 2011
Since we are talking about cancer, I have read news linking Fosamax to esophageal cancer - and that is - on top of the known Fosamax side effects.

http://www.fosamaxfemurfracturelawsuit.com/fo...
Dave

Torrance, CA

#15 Nov 29, 2011
We always need to be careful about the drugs that we take in. Zoladex is not the only one affected. There are other tons of drugs like Fosamax which you can read about here http://www.fosamaxfemurfracturelawsuit.com/fo... .
Guihan

Melbourne, Australia

#16 May 10, 2012
9438 KBS wrote:
I had radical prostatectomy in 2001 for locally advanced Ca Prostate. Soon after that I have had Zoladex injections every 12 weeks. My PSA after surgery has always been between 0.01- 0.04. Should I now stop Zoladex or use it intermittently ?
The opinions on this matter vary so much. May I have your thoughts on this matter. Thank you.
After my radical prostatectomy in 2003, my PSA was stuck on 0.1 until 2006, when it began to rise. It reached 0.8 in 2007, when my urologist started me on intermittent Zoladex (two implants in tandem, three months apart). My Psa immediately dived, but rose again to 0.17by January 2009. That cycle of tandem implants followed by a "holiday period" has now been repeated several times. I adopted the policy of beginning each new treatment cycle whilst my PSA was at a lower and lower level. I recorded all dates and PSA levels carefully, and I did a lot of charts. I have noticed something that came as a surprise: I computed the number of days between the first implant of each cycle and the subsequent reappearance of a measurable PSA (after the effects of implant #2 has worn off) and I found that the period kept kept increasing. Now, that was not the surprising thing (after all, I was starting each cycle at a lower PSA level than before). What surprised me was that my graphs of this period clearly revealed that each measred period was not only longer than the last, but it was growing exponentially. In other words, my graphs were telling me that the lower your PSA at the time of your Zoladex treatment, the (much) greater will be the period before your PSA subsequently rises again. I suspect that this phenomenon has not been studied before. It would also explain why some specialists (in Australia, at least) still adopt the policy of allowing the patient's PSA to rise to 7 or 8 before resuming intermittent therapy. From my experience, I don't think that is a very good idea.
Dave R
#17 Aug 16, 2012
A recent study actually suggests that osteoporosis drugs may help ease incapacitating bone pain that may come in as a complication of prostate cancer. However, this may also put patients at risk of side effects from bone-sparing drugs such as Fosamax. http://www.fosamax-lawsuit.net features updated information about Fosamax and related side effects.
Tanmay

Mumbai, India

#18 Aug 22, 2012
My father has undergone a Robotic Surgery in USA for Prostrate Cancer, he has been taking Zoladex injections every 3 months, this has been over the last 3 years. He was wondering if he could use Zoladex every 6 months but is afraid that PSA can go up. Can you advice his PSA currently is measured every 3 months before taking injections as is below 0.01. Can you please give me some advice urgently
Guihan

Melbourne, Australia

#19 Aug 22, 2012
Tanmay wrote:
My father has undergone a Robotic Surgery in USA for Prostrate Cancer, he has been taking Zoladex injections every 3 months, this has been over the last 3 years. He was wondering if he could use Zoladex every 6 months but is afraid that PSA can go up. Can you advice his PSA currently is measured every 3 months before taking injections as is below 0.01. Can you please give me some advice urgently
Tanmay, I am not a doctor, and can only speak from my own expertience. I have settled on 6-monthly implants and that is working for me. It is great that your father's PSA reading is <0.01, so he has a good chance of being able to switch to 6-monthly implants. It all depends on the doubling time of his cancer. My Zoladex implants reduce my PSA at a faster rate than it later climbs (as the effects of the Zoladex wear off). Mine is a pretty aggressive cancer, with a doubling time of 67 days. However, my PSA halving time (after a Zoladex implant) is just 21 days. This drives my PSA so low that, even after 6 months, the PSA does not reach the 0.01 level. I used mathematics and graphs to understand my cancer. If you can do the same (or get help to do so) you should be able to work out your father's cancer behaviour by careful use of starting values and exponential projections. I feel this is worth doing, as I suspect that using more Zoladex than is necessary may encourage the hormone treatment to fail sooner.
Rina

Hillsboro, OR

#21 Sep 21, 2012
Different drugs have their own controversies regarding its effects and some of them have been reported to occur in several patients. Bone drugs like Fosamax has been linked to inadvertent effects including femur fractures, an effect that one may think of as ironic. http://www.fosamaxfemurfracturelawsuit.com
Kurt John

Idaho Falls, ID

#23 Oct 20, 2012
Elderly men need to take note of this especially those who have been diagnosed with prostate cancer. Some information is available here. http://www.fosamaxclassaction.us
Stacie

Nassau, Bahamas

#26 Jan 25, 2013
hi my husband was has been on Zoladex now for 1 year. I want to know how long do he have to be on this

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