Bisphosphonate Side Effects: Cause Fo...

Bisphosphonate Side Effects: Cause For Growing Concern

There are 53 comments on the Press Release News From 24-7 Press Release story from Sep 26, 2006, titled Bisphosphonate Side Effects: Cause For Growing Concern. In it, Press Release News From 24-7 Press Release reports that:

They may be among the most-prescribed drugs in America, but bisphosphonates such as Fosamax, Zometa and others presribed to prevent bone loss in women and men with osteoporosis may actually cause bone death in ...

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Portland, OR

#47 Aug 8, 2011
My husband started taking this and started losing massive weight and kept having horrible pain episodes, and the oncologist just bold face lied! saying it wasn't the zometa, when he quit taking it for 3 months he started to gain weight. Now they wanted him to keep taking it again, and he has been just awful sick and bed ridden with horrible pain and losing weight! I knew it was this damn drug! This is freaking criminal and his femur has been killing him!
Lane Simonian

Reno, NV

#48 Aug 9, 2011
Fosamax and other bisphosphonate osteoporosis drugs produce peroxynitrites which kill osteoclasts--cells that take minerals out of bones.
Through DNA damage, protein nitration, oxidation, lipid peroxidation, and cell death, peroxynitrites contribute to a series of other diseases, including esophagitis, esophageal cancer, jaw osteonecrosis, "brittle bones", atrial fibrilation, and Alzheimer's disease. All but the latter have been linked to bisphosphonate drugs. The evidence in regards to Alzheimer's disease is largely circumstantial: the number of reported Alzheimer's cases has increased by nearly one million people in the United States since Fosamax began to be prescribed in the mid-1990s. Women develop the disease more often than men and many of those receiveing osteoporosis drugs are women. The larger irony is that peroxynitrites just don't kill osteoclasts, they poison the brain, heart, esophagus, and even bones.

San Jose, CA

#51 Nov 25, 2011

Chicago, IL

#52 Nov 25, 2011
It should be a concern for those using these drugs, with the side effects growing the number of lawsuits, such as a Fosamax lawsuit are also increasing as well.

Since: Mar 11

Clarks Summit, PA

#53 Dec 7, 2011
Although devastating, this is mostly true because a lot of people have been filing complaints. You can read more here .

New York, NY

#54 Dec 20, 2011
Like any other medicines, side effects are inevitably present with Fosamax (Alendronate Sodium) intake. Fosamax is an oral bisphosphonate medication created to treat and prevent osteoporosis and other bone problems. However, it has been studied thoroughly in clinical trials, wherein a group of people taking the drug have side effects documented and compared to another group not taking the medicine. Studies have also suggested that Fosamax could lead to the decay and death of other bones in the hip, knees or shoulder. The drug works by preventing bone turnover to reduce the risk of fractures. Talking about harmful medical products, Finally, ASR Hip Replacement Recall was implemented by DePuy Orthopaedics Inc., a subsidiary company of Johnson&Johnson. There are around 98,000 recipients of the ASR XL Acetabular System and the ASR Hip Resurfacing System worldwide. After the release of data presenting that these devices fail prematurely in one out of eight patients, the two devices were recalled. The manufacturing and marketing of these two devices started in 2003. The global recall of these products were announced in August 2010. More information here: .

New York, NY

#55 Jan 13, 2012
Itís ironic that bisphosphonates are prescribed to those who are suffering bone loss yet they may be the main reason for bone depletion. Such medication may weaken the skeletal system, making the patient vulnerable to fractures. Fractures, aside from the pain, became more dangerous than its usual implication after the DePuy scandal took place, with the number of hip replacement failures and lawsuits that came thereafter. See:

Bradenton, FL

#56 Feb 26, 2012
I took Actonel and now my short term memory is screwed up... I can't remember long enough to write down the songs that I used to be able to write...

Clarks Summit, PA

#57 Mar 1, 2012
Yes, I already read about it in . I hope something can be done.

Clarks Summit, PA

#58 Mar 2, 2012
Its high time for the FDA to look closely on the side effects of this drug.Fosamax and other biophosphonate were reported to cause many adverse events.


#59 Sep 13, 2012
Bisphosphonates are a group of drugs that are relatively new in regard medical treatment. In its other form, they have been formerly used for industrial purposes. This may mean that it may take more time for any other potential health problems to be recognized. It may come as no surprise that reports of side effects from bisphosphonates such as Fosamax continue to mount. It helps a great deal to be updated of these adverse effects, comprehensive and current information at may be of great help to people concerned and interested.
Meliza B

Hillsboro, OR

#61 Oct 31, 2012
It's true that the side effects of bisphosphonates are a cause of major health concerns for those taking them. Especially when people have raised serious lawsuits against its manufacturers. Read more about the Fosamax lawsuits here.
Pilar M


#62 Dec 22, 2012
Bisphosphonates continue to be a growing concern for those taking them. People need to be mindful of them and consider that if they do not tolerate taking this type of osteoporosis medication, then, they should consider other forms of treatment.

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