Targeted drugs in focus ahead of cancer meeting
The next wave of cancer therapy is focused on better ways of matching medicines to patients and on keeping tumors from recurring following successful treatment.
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Since: Dec 05
#1 May 20, 2011
Just think of all the time and money that could be saved if the drugs we already have were used more wisely, instead of concocting all these new and horrendously expensive targeted drugs and relying on maintenance therapy?
Many conventional chemotherapy drugs, in addition to killing tumor cells, also fight angiogenesis. The anti-angiogenic effects of therapy are masked and marginalized by the way it is usually administered. There are generally long breaks between drug administration that are necessary to allow the patient to recover from the harmful side effects of treatment.
When administering these drugs, the endothelial cells (involved in angiogenesis) are the first in the tumor to undergo cell death (apoptosis). However, this anti-angiogenic effect does not translate into a significant therapeutic benefit because the damage to the vasculature of the tumor can be largely repaired during the long rest and recovery periods between successive cycles of therapy.
The more frequent, lower-dose therapy can have an impressive anti-angiogenic and anti-tumor effects. Blood vessel cells are less likely than tumor cells to become resistant to chemotherapy, so if cancer cells become drug resistant, these medicines should still be able to shrink tumors by destroying their blood supply.
The main targets of dose-dense chemotherapy are proliferating tumor cells. The main targets of low-dose chemotherapy are the endothelial cells of the growing vasculature of a tumor. In other words, chemotherapeutics can be used as anti-angiogenic agents.
But this type of protocol willl never make the pharmaceutical companies gobs of money!
#3 Sep 23, 2013
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