Dr Nase Research and Elidel Rosacea Tx

Dr Nase Research and Elidel Rosacea Tx

Posted in the Rosacea Forum


Dallas, TX

#1 Jul 29, 2012
I remember reading Dr. Nase's book 12 years ago when Elidel was just being researched in its infancy for Atopic Dermatitis.

Based on Dr. Nase's research and knowledge of how Elidel, which just had a number back then, he came to the conclusion that this might be a weapon against rosacea redness and papules.

This was developed for a completely different disorder.

Elidel is now also a very good rosacea treatment that reduces facial redness, papules, pustules, and is one of the rare treatments that clears steroid rosacea.

That's exactly why the Rosacea Community still turns to Dr. Nase. He had a magical crystal ball on this one... or just darn good research by a physiologist.

I speak for everyone... thanks Dr. Nase


Dallas, TX

#2 Jul 29, 2012
Here are some of the articles that were posted on his Rosacea Forum:

Clin Exp Dermatol. 2010 Apr;35(3):251-6. Epub 2009 Jul 6.

A comparison of metronidazole 1% cream and pimecrolimus 1% cream in the treatment of patients with papulopustular rosacea: a randomized open-label clinical trial.

Koca R, Altinyazar HC, Ankarali H, Muhtar S, Tekin NS, Cinar S.

Department of Dermatology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey. [email protected]



There are various treatment options available for rosacea, depending on the subtype, but treatment is still generally unsatisfactory. Some reports have indicated beneficial effects of topical pimecrolimus.

To compare the efficacy and safety of pimecrolimus 1% cream and metronidazole 1% cream in the treatment of patients with papulopustular rosacea (PR).


A group of 49 patients with PR was investigated in this single-centre, randomized, open-label study. Patients were randomly assigned treatment with either pimecrolimus 1% cream or metronidazole 1% cream for 12 weeks. Response was evaluated by the inflammatory lesion count, the severity of facial erythema and telangiectasia, Physician's Global Assessment (PGA), and safety and tolerability at baseline and at weeks 3, 6, 9 and 12.

In total, 48 patients completed the study. Both treatments were very effective in the treatment of PR.

This is a very effective treatment for rosacea as you can see and no one even heard of this 12 years ago.


Dallas, TX

#3 Jul 29, 2012
Dr. Nase posted this a while back on his forum also. Great results of Elidel on inflammatory rosacea:

J Dermatol. 2011 Dec;38(12):1135-9. doi: 10.1111/j.1346-8138.2011.01223 .x. Epub 2011 Sep 28.

Pimecrolimus 1% cream for the treatment of rosacea.
Kim MB, Kim GW, Park HJ, Kim HS, Chin HW, Kim SH, Kim BS, Ko HC.

Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.

Rosacea is a common inflammatory skin disorder; the pathogenesis is unclear. Various treatment options for rosacea are available, but most have limited effectiveness. The aim of this study was to investigate the efficacy and safety of 1% pimecrolimus cream for the treatment of rosacea. Thirty patients with rosacea were enrolled in this 4-week, single-center, open-label study of 1% pimecrolimus cream. Patients were instructed to apply the cream to their faces twice daily and were not permitted to use any other agents. Clinical efficacy was evaluated by a rosacea grading system using photographic documentation and a mexameter. The 26 patients who completed the study experienced significantly reduced rosacea clinical scores from 9.65 1.79 at baseline to 7.27 2.11 at the end of treatment (P < 0.05). The mexameter-measured erythema index decreased significantly from 418.54 89.56 at baseline to 382.23 80.04 at week 4 (P < 0.05). The side-effects were mostly transient local irritations.

The results of this study suggest that 1% pimecrolimus cream is an effective and well-tolerated treatment for patients with mild to moderate inflammatory rosacea.

2011 Japanese Dermatological Association.

Dallas, TX

#4 Jul 29, 2012
Most forums are just re-releasing news that everybody has and knows. Oracea and Metrogel.

Dr. Nase has always been the exception to the rule from his strontium to zincO, to oatmeal cleanser testing and recommendations, to his oral rosadyn and his upcoming topical rosadyn.

We need more Dr. Nase's. More ground breakers. More innovators. More researchers that come through for us. Derms are just not getting it done... they just don't understand and never will. We all know what it's like to live with Rosacea. That's why I'm so glad we have Dr Nase as our rosacea advocate to set the derm world on notice and point them in the right direction.


Dallas, TX

#5 Jul 29, 2012
I had a severe case of steroid rosacea with see-through skin and massive amounts of blood vessels. Derms labelled me untreatable.

Not Dr. Nase. Recommended Elidel for this very treatent 12 years ago and it changed my life and cleared almost all my symptoms. This is backed up by clinical studies now:

Br J Dermatol. 2008 May;158(5):1069-76. Epub 2008 Mar 20.

Pimecrolimus 1% cream for the treatment of steroid-induced rosacea: an 8-week split-face clinical trial.

Lee DH, Li K, Suh DH.

Department of Dermatology, Seoul National University College of Medicine, 28 Yongon-Dong, Chongno-Gu, Seoul 110-744, Korea.


Steroid-induced rosacea is a relatively common dermatosis that is caused by the prolonged application of topical steroid to the face.

The purpose of this investigator-blind, split-face study was to evaluate the efficacy and safety of pimecrolimus 1% cream for the treatment of steroid-induced rosacea.


Patients were instructed to apply pimecrolimus 1% cream twice daily to the involved areas of a randomly allocated half side for the first 2 weeks, and to follow this by applying pimecrolimus 1% cream to both sides for a further 6 weeks.


Fifteen of the 18 patients completed the 8-week study. After 1 week of application, a statistically significant improvement was observed for investigator's global assessments of erythema and papules on prior-treated sides (P-side). Later-treated sides (L-side) showed subsequent improvement after use of pimecrolimus on the L-side. Likewise, a statistically significant improvement was also observed for numbers of papules/pustules on P-sides after 1 week, and L-sides showed a significant improvement after application of pimecrolimus on the L-side. Comparative reflectance colorimetric assessments revealed that DeltaL*, Deltaa* and Deltab* tended to converge to zero during the first 4 weeks. A statistically significant improvement was observed for percentage area affected on P-sides after 1 week of application. The L-side showed a significant improvement after use of pimecrolimus cream on that side. The visual analogue scale of P-sides decreased more rapidly than those of L-sides. Cutaneous side-effects were mild and transient.


This study suggests that pimecrolimus 1% cream is an effective and well-tolerated treatment for steroid-induced rosacea

No one else would have ever known about this treatment and I would have never gotten better without Dr. Nase's unique background and research.

So, for me (and many many others)... THANK GOD for Dr. Nase.

Forever in debt.


Phoenix, AZ

#6 Jul 29, 2012
Dr. Nase pointed out in his forum that elidel is especially useful for rosacea sufferers that are "untreatable" and left without hope.

In a study he quoted (sorry doc for stealing your research), 12 rosacea sufferers that failed all other treatments noted significant clearance of facial redness and an 80% reduction in papules and pustules!!!

Who could have performed this cutting edge research 12 years ago on a drug developed for a different skin disorder and came through for us like this? Nobody on any forum, blog or publication that we know of. Rosacea treatment with vinegar is still the hottest topic in the few remaining forums because they have no idea what to discuss as we are not researchers. The other hot topic is generic metronidazole vs metrogel. Jeez...

From Dr. Nase's forum for untreatable rosacea sufferers:

Skinmed. 2005 May-Jun;4(3):147-50.

Pimecrolimus for treatment of acne rosacea

Crawford KM, Russ B, Bostrom P.

Dermatology Clinic, Malcolm Grow Medical Center, Andrews Air Force Base, MD 20762, USA. [email protected]


Rosacea is a common disease, which is often resistant to treatment. Topical calcineurin inhibitors have been efficacious in the treatment of other inflammatory disorders of the skin, and tacrolimus has been reported as an effective treatment option for erythrotelangiectatic rosacea.


Because of the benefits seen with tacrolimus in previous publications, we investigated the efficacy of a closely related compound, pimecrolimus, in patients with erythrotelangiectatic, papulopustular, and edematous rosacea.


Twelve patients with erthryotelangiectatic or papulopustular rosacea who had failed conventional therapy were treated with topical pimecrolimus cream twice daily for 12-18 weeks. No patients had used any other treatment for rosacea within 30 days of the start of therapy. During the course of the study, no other topical or systemic treatment of rosacea was allowed.


Ten of 12 patients showed substantial improvement of erythema, while five of six patients with a papulopustular component noted at least an 80% decrease in the number of lesions.


It appears pimecrolimus may be efficacious in the treatment of erythrotelangiectatic and papulopustular rosacea and may be considered in patients with recalcitrant disease.


Chantilly, VA

#7 Jul 29, 2012

Thank you for sharing your story and Dr. Nase's research and articles. Sorry you had to go through that but I was also "untreatable" for 17 years after years of steroid treatment given to me by dermatologists. Then they just let me go with no hope and no treatment. Dr. Nase's book and his research into Elidel turned my life completely around.

To this day most derms still do not know about Elidel and its use in rosacea. That completely dumbfounds me. Do they not do research or read journal articles?

Here's another clinical study that Dr. Nase discusses on his forum... I can't wait until he gets the newest forum up and running again, but he's only one person so I will let him slide on this one:)

Hautarzt. 2007 Apr;58(4):338-42.

[Steroid-aggravated rosacea: successful therapy with pimecrolimus].

Meykadeh N, Meiss F, Marsch WC, Fischer M.


Steroid-induced erythema in rosacea is a therapeutic challenge because of its tendency to rebound and the local characteristics of the facial skin. We describe 3 cases of steroid-induced rosacea with the typical history of steroid abuse with tachyphylaxis. Steroids with increasing potency had to be used with increasing frequency in the course of treatment in order to achieve a response. Acute exacerbations followed any attempt at withdrawal. The steroid treatment was discontinued and therapy with pimecrolimus cream 1% twice daily initiated. This brought rapid and marked improvement within a few days.

The cases show that the calcineurin antagonist pimecrolimus offers an effective and well-tolerated therapy option in the acute therapy of steroid-aggravated facial dermatoses.

Elidel was the only thing that would have ever helped me and Dr. Nase was the only source of information and research into this area outside the rosacea box.

All the best Geoffrey. Thank you.

Chantilly, VA

#8 Jul 29, 2012
Please continue your research efforts... you are one of the best sources of research and information that people like myself can turn to.


Since: Nov 08

Location hidden

#9 Jul 29, 2012
Lol, you crack me up Dr. Nase.

Dallas, TX

#11 Jul 29, 2012
Elidel was the best addition to my rosacea routine. Some may experience a minute or two of skin warmth sensations but I believe that's due to the Elidel's anti-inflammatory component causing the redness and blood flow to move along.

This helped me mostly with treatment-resistant facial redness and each month I use it, the redness fades even more.

Every dermatologist I've been to has never heard of
Elidel for rosacea.

Dr. Nase pulled this bunny out of his hat.

I hope he publishes a journal article on this so more doctors know about this option.

Since: Jul 12

Location hidden

#13 Jul 29, 2012
Jason1970 wrote:
Solid. No whitty retort by the peanut gallery. LOL
No need Nase because the "NUTS, CLUELESS, SPAM or DISAGREE" judging symbols fit your posts perfectly :)

Cardiff, UK

#20 Jul 29, 2014
I have this cream off my skin specialist --not sure to use it when it is red or not - as was told both ways by 2 different specialist-- now I will try it morning and night and hope I am as Lucky as you all have been - can not stand this itchy stingy Burny feeling of Rosacia :-(

New York, NY

#21 Sep 12, 2015
I began to suffer from rosacea in my late fifties. I tried all the over counter products that promise to reduce the redness and spots within hours ....they didn't. i always felt an irritation under the spots which meant I was constantly touching...and made it worse. After the first application of the Made from Earth Green Tea Cleanser & Rosehip Hibiscus Serum - my skin felt calm. No the spots and redness didn't disappear overnight but the skin felt so comfortable that I continued with it for that reason. After 1 week of using the Made from Earth Rosehip Serum there was an amazing improvement and after 2 weeks .....clear of spots and redness reduced . To those who are not having immediate results........I would say 'persevere'. After a month my skin is the best it has been for 10 years.

New York, NY

#23 Dec 1, 2015
Why would you want to use steroid creams all the time? It the long run they will ruin your skin! I also suffered from rosacea for many years - nose and forehead area....i used EVERY steroid cream, and while they sometimes worked, they also left me with burning and they stopped working after a while. I recommend you switch to more natural and gentle products. I currently only use natural stuff. I still have yet to find a face cleanser I reocmmend (they are all harsh for me), but as a moisturizer, the Somaluxe Redness Repair is what I use. It does really calm my skin - especially if my rosacea gets worse - I apply that twice a day, and in 24 hours the redness is gone.

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