FDA Warns About Cipro, Other Antibiotics

FDA Warns About Cipro, Other Antibiotics

There are 71 comments on the NBC 10 Philadelphia story from Jul 8, 2008, titled FDA Warns About Cipro, Other Antibiotics. In it, NBC 10 Philadelphia reports that:

Drug safety officials Tuesday imposed the government's most urgent safety warning on Cipro and similar antibiotics, citing evidence that they may lead to tendon ruptures, a serious injury that can leave ...

Join the discussion below, or Read more at NBC 10 Philadelphia.

Mike

Seattle, WA

#43 Sep 16, 2008
I was on cipro in 2001. Every day is still hell. I know we need drugs like this but not for simple things. The doctors are being had by the drug companys.
EL Kabong

Glenmoore, PA

#44 Sep 16, 2008
Mike wrote:
I was on cipro in 2001. Every day is still ****. I know we need drugs like this but not for simple things. The doctors are being had by the drug companys.
It's really up to the doctor to have the knowledge and experience to prescribe the appropriate medication. Mine at least knows that if I have a minor bronchial, ear, whatever infection, she's not going to prescribe a high yield antibiotic like cipro.
Jim

Whitby, Canada

#45 Dec 1, 2008
Tendon ruptures are just one of many serious side effects brought on by a reaction to the quinolone antibiotics. What goes unrecognized is that their side effects are far worse than what one would normally expect from a drug in that they last for months and even years and they can show up months after stopping the drug. What hurts the victims so much, and what guarantees that their will be more victims every day, is the fact that doctors and drug companies don't recognize these facts.
Jay B

London, UK

#46 Dec 3, 2008
I agree with Zakkismom. All this nonsense over an antibiotic is scaring some people who really need this drug.
I have prostatitis and have been on so many different forms of antibiotics that I have lost count. Cipro is the only one that has brought me replief from this condition and I have not had any serious side effects from taking it apart from some very strange dreams which in all honesty I enjoy. I've been on Cipro 2 x 500 for over 5 weeks now and im still here alive and able to write this message with no problems. I work out 3-4 times a week in the gym, no tendon ruptures or muscle pain.
Yes some individuals will experience bad side effects from taking this and I agree that doctors should monitor patients who are taking this medication but as far as scaring everyone to death with all the stories on here its crazy.
If I take Ibuprofen it causes me to have a nasty reaction resulting in anaphylactic shock but you dont see any forums or scare storied pasted on the internet about this drug. This one did nearly kill me but as far as cipro is concerned it is a wonder drug that has brought me relief from the discomfort and pain that I was going through.
If you are prescribed cipro take it BUT if you do exerience any adverse side effects then of course stop straight away and rin gyour doctor. Stop these scare stories. Has anyone never heard of the placebo effect and by reading this stuff you can actually give yourself the side effects that you are scared of getting in the first place.
Get back into reality and understand that all drugs can cause side effects.
Lance

Packwood, IA

#47 Dec 14, 2008
I just started Cpro for a tooth infection, and was playing table tennis and my right hamstring strained or a slight tear occured.

Does anybody know what antibiotic is considered a good alternative to this one which works well for the infection I had. Pencillin doesn't seem to work for me?
Concerned Son

Tallahassee, FL

#48 Jan 8, 2009
If there's anyone still looking at this forum, do you know of any class action suits? From everything I'm reading it should not be long now before people get together and stop another drug company from making billions...
xargaw

Everett, WA

#51 Jan 16, 2009
To those that think that the reported outrage over quins/floxins is overblown, they are obviously not victums. Tendon problems would be welcomed by many victums that have suffered the other side effects of mental disturbances, acute gastrointestinal distress, liver, kidney, pancreas, nuerological effects. People are sick for months or years after taking these drugs. Everyday brings a new and ghastly reaction long after the medication is taken. These drugs are poison to large numbers of people. MOST doctors have almost NO knowledge of the potential hazards of these drugs and base their opinions on the "sales pitch" of the pharma reps. My own Doc "googled" the drug when I told him what was happening to me and was surprised with the information. He didn't even know the drug had been "black boxed." Today, pharma does their own testing and clinical trials without outside scrutiny and then prepares it for the FDA. Post marketing reporting of side effects for these drugs show how pharma has distorted, buried and manipulated unfavorable data. Personally, I will never take another drug until I have done my own research. You can not trust pharma and most Docs are ignorant regarding the dangers of this family of drugs.

Since: Jan 09

Almaty, Kazakhstan

#52 Jan 30, 2009
My uncle takes Cipro from http://totaldrugs24.com/item/cipro.html It really helps him
william shaw

Kansas City, MO

#53 Feb 22, 2009
Charlotte Wales wrote:
I took Ciprofloxacin this past January for an upper-respiratory virus going around town. I am pretty much a naturalist, and very healthy - haven't had to go to a doctor for anything in many years. This virus filled my lungs, and I finally went, was prescribed Cipro, and within 3-4 days, had virtually every adverse reaction on their paper, plus a few others. I took myself off the drug on the 5th day, and went back to the doctor, who gave me a powerful shot of steroids to counteract the Cipro, and also oral steroids for 7 days. I did have calf pain - intense pain, but luckily, no permanent damage. My main problem continues to be my eyes - they burned and turned very bloodshot when I took Cipro, and got worse each day. When I returned to see the doctor, she prescribed some eyedrops ($50 for a tiny bottle!) that only made it burn worse. I continued with them for a few days, despite the increaded pain; I virtually looked like my eyes would start bleeding at any moment - scary. So, I took myself off the eyedrops, and the pain finally stopped. However, it comes and goes, the pain and the redness, and now, my vision has been affected in my left eye. I'm going to seek legal and medical help with this, as my eyes are damaged, I hope not permanently, but that remains to be seen. Has anyone else had this reaction?
I took cipro 500 mg 2x a day and had severe eye redness that has not disappeared 5 days after stopping. Extreme eye redness was reported in the initial drug evaluation at a rate of 1 in 200.
Shells

AOL

#54 Feb 24, 2009
Charlotte....IF the Eyedrop is called VIGAMOX...it is also a FLUOROQUINOLONE.

You may want to check that!!

~Shells~
Charlotte Wales wrote:
I took Ciprofloxacin this past January for an upper-respiratory virus going around town. I am pretty much a naturalist, and very healthy - haven't had to go to a doctor for anything in many years. This virus filled my lungs, and I finally went, was prescribed Cipro, and within 3-4 days, had virtually every adverse reaction on their paper, plus a few others. I took myself off the drug on the 5th day, and went back to the doctor, who gave me a powerful shot of steroids to counteract the Cipro, and also oral steroids for 7 days. I did have calf pain - intense pain, but luckily, no permanent damage. My main problem continues to be my eyes - they burned and turned very bloodshot when I took Cipro, and got worse each day. When I returned to see the doctor, she prescribed some eyedrops ($50 for a tiny bottle!) that only made it burn worse. I continued with them for a few days, despite the increaded pain; I virtually looked like my eyes would start bleeding at any moment - scary. So, I took myself off the eyedrops, and the pain finally stopped. However, it comes and goes, the pain and the redness, and now, my vision has been affected in my left eye. I'm going to seek legal and medical help with this, as my eyes are damaged, I hope not permanently, but that remains to be seen. Has anyone else had this reaction?
Shells

AOL

#55 Feb 24, 2009
These are NOT mere "side effects" but adverse reactions due to the toxic nature of this particular class of antibiotic. The doctors are the ones who need to be doing their jobs by NOT prescribing these powerful antibiotics as first line of defense. The damages are very real, severe, and often permanently debilitating. They are being given out like candy regardless of condition or age....even prescribed to otherwise healthy CHILDREN who merely need a safer antibiotic for ear and eye infections. Not worth risking a childs life because of doctors' ignorance. Glad it has helped your child though. Very different story.(I have a ZACH too) Hard to be thankful when a previously healthy person is suddenly crippled for life. Good luck and best to you and your boy.

~Shells~
Zakkismom wrote:
Cipro has saved my son's life, repeatedly, when he has had pulmonary (lung) infections and resultant hemorrhages (lots of blood not a little). This miracle drug I am very thankful for. This kind of nonsense - of people being bitter over the side effects of a medication that SAVES others' lives - shows how spoiled and mean spirited some people are. If people are able to rupture a tendoon while on this very strong medication, than perhaps they did not need Cipro in the first place and it should be reserved for the patients who need it the most and wouldn't complain if their lives were saved but had side effects. By the way, every drug has side effects - both positive and negative. So does alcohol...but I bet you don't go and sue the company that makes the alcohol because it made you drunk and stupid!
Shells

AOL

#56 Feb 24, 2009
Hello, I am also a victim of LEVAQUIN and AVELOX poisoning. For my tooth infection, my dentist prescribed Clindamycin (300 mg 3x's/day), and I took it with no problem.

~Shells~
Lance wrote:
I just started Cpro for a tooth infection, and was playing table tennis and my right hamstring strained or a slight tear occured.
Does anybody know what antibiotic is considered a good alternative to this one which works well for the infection I had. Pencillin doesn't seem to work for me?
Shells

AOL

#57 Feb 24, 2009
Again....we are NOT dealing w/ mere side effects, but serious, often disabling and permanent adverse reactions due to the toxic nature of this class of antibiotic. Calling this drug an antibiotic is putting it mildly. It "works" by destroying HEALTHY DNA....the damage is being done, and continues long after the drug is stopped. How's that for a scare....just wait for the straw that broke the camels back....or for the timebomb to go off. Believe me...being POISONED is not pretty.

~Shells~
Jay B wrote:
I agree with Zakkismom. All this nonsense over an antibiotic is scaring some people who really need this drug.
I have prostatitis and have been on so many different forms of antibiotics that I have lost count. Cipro is the only one that has brought me replief from this condition and I have not had any serious side effects from taking it apart from some very strange dreams which in all honesty I enjoy. I've been on Cipro 2 x 500 for over 5 weeks now and im still here alive and able to write this message with no problems. I work out 3-4 times a week in the gym, no tendon ruptures or muscle pain.
Yes some individuals will experience bad side effects from taking this and I agree that doctors should monitor patients who are taking this medication but as far as scaring everyone to death with all the stories on here its crazy.
If I take Ibuprofen it causes me to have a nasty reaction resulting in anaphylactic shock but you dont see any forums or scare storied pasted on the internet about this drug. This one did nearly kill me but as far as cipro is concerned it is a wonder drug that has brought me relief from the discomfort and pain that I was going through.
If you are prescribed cipro take it BUT if you do exerience any adverse side effects then of course stop straight away and rin gyour doctor. Stop these scare stories. Has anyone never heard of the placebo effect and by reading this stuff you can actually give yourself the side effects that you are scared of getting in the first place.
Get back into reality and understand that all drugs can cause side effects.
Shells

AOL

#58 Feb 24, 2009
WRONG!! I have personally stopped two babies from being exposed to CIPRO EARDROPS and VIGAMOX EYEDROPS....but unfortunately my own son, at 6 yrs of age was prescribed VIGAMOX eyedrops (before I knew about the TOXICITY of this class of antibiotic). These deadly antibiotics are also currently being RESEARCHED using CHILDREN as human guinea pigs. Please go to FQRESEARCH.ORG for the TRUTH about FLUOROQUINOLONE TOXICITY.

~Shells~
OMGWTF wrote:
This really isn't news. Quinolones are rarely prescribed for children for this very reason.
TBY

United States

#59 Feb 24, 2009
People like Zakkismom and Jay 8 just don't get it. It's like saying: sure, I played russian roulette and nothing happened to me! That's how stupid they sound to someone like me that had a severe Adverse reaction to Cipro and am now crippled. I have all kinds of other CNS problems that would blow your little minds if you only knew. These drugs are TOXIC POISON! Try going from great health to a complete wreck in 2 weeks and having your life and finances ruined because your stupid Dr. gave you Cipro for a simple UTI. I could have been given half a dozen other less toxic antib's instead. Cipro is over used plain and simple. If you think it's such a great drug, keep taking it and see what happens. nobody gets away undamaged. It just takes a little longer for that damage to show up for some. people should be scared to death of this drug...and for good reason
bob

United States

#60 Jan 18, 2010
As I under stand the british journal of medicine study, the fluoroquinolones do not attack tendons directly. they attack the tissues which transport nourishment in and wasteproducts out of the tendons. The tendons actually rupture later because they are dying(necrotic tissue).
The fluoroquinlones are also said in the study to cause perforations in the brain/blood barrier to the brain.
In the BJM study of rats given one series of the drug (as we would receive for say a bladder infection), The rats' collagen production was down 68%. and capability of tissues to nourish tendon reduced 36 to 38%.
google: jason alexander uttley, fluoroquinolones.org and aforementioned fqresearch.org
fiona

Ballina, Ireland

#61 Feb 28, 2010
ciproxin was prescribed for my 16 year old son three weeks ago for a bacterial infection, he is now lying in agony, the pain in his legs is so severe, can anyone advise me what to do for him, thank you
Sally Kosmalski

Clinton, IL

#62 Apr 3, 2010
Zakkismom wrote:
Cipro has saved my son's life, repeatedly, when he has had pulmonary (lung) infections and resultant hemorrhages (lots of blood not a little). This miracle drug I am very thankful for. This kind of nonsense - of people being bitter over the side effects of a medication that SAVES others' lives - shows how spoiled and mean spirited some people are. If people are able to rupture a tendoon while on this very strong medication, than perhaps they did not need Cipro in the first place and it should be reserved for the patients who need it the most and wouldn't complain if their lives were saved but had side effects. By the way, every drug has side effects - both positive and negative. So does alcohol...but I bet you don't go and sue the company that makes the alcohol because it made you drunk and stupid!
Apparently you don't know the devistating effect of Cipro. First, could another antibiotic have saved your son's life? What would they have given him before Cipro was around?
I have been suffering for 17 months and the end is no where in sight. I have lost a job and my life has been ruined. I can't do my everyday household chores, nor walk very far because I'm in constant pain. The drug manufacturer knew this, and so must have the FDA, before they ever released it.
Well, it is not entirely clear what causes the tendon rupture with quinolones (cipro). Studies have implicated ischemic, toxic, and matrix-degrading processes which cause degenerative tendon lesions with interstitial edema and necrosis. It is apparent that quinolone-induced tendon rupture more often occurs in less vascularized areas (such as the legs), which further supports an ischemic process. In laboratory studies, exposure of tendon tissue to ciprofloxacin showed a 60% to 68% decrease in fibroblast proliferation, a 36% to 48% decrease in collagen synthesis, a 14% to 60% decrease in proteoglycans synthesis, and a significant increase in matrix-degrading proteolytic activity after only 72 hours in culture. So it appears that the quinolone is somewhat poisonous (cytotoxic) to the tendons.
In terms of rehabilitating the tendon, there is, unfortunately, no magic bullet. The problem with quinolone exposure is that it can cause tendon rupture months, even years, after exposure to the medication. I spent a lot of time this morning reviewing the literature and aside from conservative treatment of splinting, etc.. there is no medication to reduce the inflammation...
Best wishes
DoctorRich (Online)-- Doctor -- 99% Positive Feedback on 965 Medical Accepts
American Board Certified in Emergency Medicine
Nobody, and I repeat nobody and not the print out that came with the Rx, told me about any possible serious side effects.
Hopefully your son won't have any delayed and negative reactions to the drug, because it's poison to tendons.
Sally Kosmalski

Clinton, IL

#63 Apr 3, 2010
Hopefully you're never affected with those negative side effects, nor your son either, because if you were you'd be filing a lawsuit too. The drug company deliberately withheld the damaging information until Public Citizen Advocacy Group filed a lawsuit against the FDA in Jan. 2008, because they had known about the problem for 10 years and had done nothing, and I repeat NOTHING, about it during that time. No doctor ever told me about the dangers.
thisisit

East Northport, NY

#64 Apr 12, 2010
you should search for adverse effects at http://www.medsafetyinfo.com/aers.html ...

it's so easy and it's free. no registration required. it's real data from the FDA.

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