Biomarker of radiotherapy induced malignancies in pediatric Hodgkin's lymphoma
Posted in the Lymphoma Forum
#1 Jul 25, 2011
Researchers have identified two variants at chromosome 6q21 associated with radiation therapyinduced second malignant neoplasms (SMNs) in survivors of Hodgkin's lymphoma treated with radiation therapy as children but not as adults. The variants comprise a risk locus associated with decreased basal expression of PRDM1 (encoding PR domain containing 1, with ZNF domain) and impaired induction of the PRDM1 protein after radiation exposure. These data suggest a new gene-exposure interaction that may implicate PRDM1 in the etiology of radiation therapy-induced SMNs. News link: http://www.sciclips.com/sciclips/biomarker-ne...
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