possible HIV vaccine and cure

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andrew j langham

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Jul 7, 2010
 

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Gram-negative bacterium such as pylori that colonizes the human stomach, secretes a toxin known as VacA. This toxin was initially identified based on its ability to cause vacuolation in cultured gastric epithelial cells. VacA causes several other alterations in gastric epithelial cells and targets multiple types of immune cells. Most VacA-induced cellular alterations are attributable to insertion of the toxin into cellular membranes and the formation of membrane channels this is thought to be acheived by bizarre estrifcation with testosterone possibly a single carbon strand similar to manufactured tamoxifen; it may be the case that HIV is intially caused in this manner and may be on going to a certain extent, along with the conventional thinking as regards Hiv transmission!
andrew j langham

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Jul 7, 2010
 

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note; pylori VacA toxin is prevelent in the lower bowel; along with natural alcohols, all manner of acids, water, and testosterone; so it follows that testosterone estrification can take place easily and can easily be absorbed through the anal tract at any juncture! esterase may not be able to break up this type of esterification in the same way as it cannot breakup the manufactured tamoxifen molecule complex! needs careful research urgently;
andrew j langham

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Jul 7, 2010
 

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The main reason that some individual's have natural immunity against Hiv is the fact they make natural antibodies that act against corrupt testosterone ie testosterone that has been under gone estrification with pylori toxin hiv contamination; these IgG globulin marked testosterone prevents transcription when docking on zinc fingure arrays; similar to tamoxifen in action; however normal testosterone will dock on receptors and will transcript correctly; so here lies the answer to a Hiv vaccine and cure combined! make a vaccine that blocks corrupt estrified testosterone but note allows normal unaldulterated testosterone to dock successfully:
andrew j langham

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Jul 23, 2010
 

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sophia a brown derby uk wrote:
Helicobacter pylori has a particular affinity to cholesterol. It is not known, however, whether other steroidal substances are bound as well. In order to characterize the specificity and nature of the H. pylori–steroid interaction, the affinity of H. pylori to cholesterol and several steroidal hormones was investigated. Seven strains of H. pylori (five reference strains, two wild strains) and one strain each of Staphylococcus epidermidis and Escherichia coli were cultured on a cholesterol-free medium. Cholesterol-free bacteria were incubated with cyclodextrin-mediated cholesterol and several cyclodextrin-mediated steroidal hormones (beta-estradiol, testosterone, progesterone, hydrocortisone, dexamethasone). The steroid contents of the bacteria were determined by gas liquid chromatography. High amounts of cholesterol were detected in all H. pylori strains, whilst steroidal hormones were not found. Neither S. epidermidis nor E. coli showed an appreciable amount of cholesterol in the chromatographic examinations. Bacterial pretreatment with proteinase K diminished cholesterol adsorption of H. pylori. These data indicate a specific affinity of H. pylori to cholesterol.
however pylori toxin does indeed bond with hormones forming single carbon strand esters especially affiliating to testosterone, which then enters cells and causes mis-transcription which maywell be the way the Hiv virion is initially established; this needs immediate careful research as soon as possible;
andrew j langham

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Jul 23, 2010
 

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the nuclear receptor of testosterone is present in all mammal cells; like that of all the steroid hormones, is a zinc finger protein and will accept single carbon esters of attached testosterone & DHT of which esterase cannot dissolve the bonding; what takes place is:- the testosterone molecule docks as normal and the carbon ester tail interferes with nucleartides disrupting secondary bonding and reverse DNA; The chromatins fixate incorrect gene formations upon zinc fingure arrays so that then results in incorrect STAT signalling; which consequently forms anamated varions; of which HIV gag proteins are then produced and go on to corrupt the genes that produce testosterone within the gonads, ovaries and adrenal cortex glands; so a Hiv vicious circle is produced; which infiltrates all cells; note; when an Hiv virion breaks down it releases corrupt testosterne; it is the corrupt testosterone thar enters other cells and proliferates the Hiv virus; and establishes its Hiv corruption, thus multiplying its gag tat protein chain variations which form closed loops;ie an Hiv capsid; we need a vaccine that will act solely against corrupted testosterone ie preventing docking registration and leaves normal unadultrated or administered testosterone to function as normal;
andrew j langham

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Jul 23, 2010
 

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the nuclear receptor of testosterone is present in all mammal cells; like that of all the steroid hormones, is a zinc finger receptor protein and will accept single carbon esters of attached testosterone & DHT of which esterase cannot dissolve the bonding;
what takes place is:- the testosterone molecule docks as normal and the carbon ester tail interferes with nucleortides disrupting secondary bonding and reverse DNA; The chromatins fixate incorrect gene formations upon zinc fingure arrays so that then results in incorrect STAT signalling; which results in the formation of HIV gag proteins and various hiv glycogen proteins;

note; various chains also form to produce Hiv chain capsids ie 'the actual Hiv virus' and go on to corrupt the genes that produce testosterone within the gonads, ovaries and adrenal cortex glands; so a Hiv vicious circle is produced; which infiltrates all cells; note; when an Hiv virion breaks down it releases gag proteins that corrupt testosterone; it is the corrupt testosterone that then enters other cells such cd4 and cd 25 & B memory cells and proliferates the Hiv virus; and establishes its Hiv corruption, thus multiplying its gag tat protein chain variations which form closed loops; ie an Hiv capsid; we need a vaccine that will act solely against corrupted testosterone ie preventing docking registration and leaves normal unadultrated or administered testosterone to function as normal;
andrew j langham

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Jul 23, 2010
 

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note; Hiv breaks down the cd 25 mechanism within B memory cells this is why cd 4 T cell activation fails and therefore, necessary IL 2 becomes unavailable and so cells will not effect a successful mitosis cycle, so the infected cells apoptically die; and body cell density waisting occurs;
andrew j langham

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Jul 31, 2010
 

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HIV has nine recognized genes (compared to more than 600 genes in a bacterium, and around 25,000 in a human). Three of the HIV genes, called gag, pol and env, contain information needed to make structural STAT proteins for new virus particles. The other six genes, known as tat, rev, nef, vif, vpr and vpu, code for proteins that control the ability of HIV to infect cells, example; some block protein A & G ; in B memory cells and alters Immunoglobulin G marking and antigen targeting capabilities;
At either end of each strand of RNA is a sequence called the long terminal repeat; which stops atomatic immune defences breaking up the closed loop; example; intergrase;
note; hiv corrupted testosterone esters trespass in and out of all cells especially the Hiv virus and are even processed within tiny emitted particles of hiv virions;it is the the corrupt testosterone that causes the vast amount of Hiv protein chain sequences making it so very difficult to target the virus and irradicate it from every cell within the human body;

research needs to urgently carried out in order to investigate hiv corrupted testosterone single stranded esters that esterase or the absense of esterase enzymes cannot degrade and abort the action of these hiv corrupt testosterone esters; a vaccine is needed that blocks corrupt testosterone but allows normal or administered testosterone to dock upon cell receptors as normal;
andrew j langham

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Aug 1, 2010
 

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The primary mechanism of action for testosterone receptors is direct regulation of gene transcription. The binding of an androgen to the androgen receptor results in a conformational change in the receptor and zinc fingure arrays which in turn causes dissociation of heat shock proteins, transport from the cytosol into the cell nucleus, and dimerization. The testosterone receptor dimer binds to a specific sequence of DNA known as a hormone response element. testosterone receptors interact with other proteins in the nucleus resulting in up or down regulation of specific gene transcription. Up-regulation or activation of transcription results in increased synthesis of messenger RNA which in turn is transcribed by ribosomes to produce specific STAT proteins. One of the known target genes of androgen receptor activation is insulin-like growth factor I (IGF-1)
note; testosterone has to be present in all cells in order for transcription to take place along with IL2 growth hormone or mitosis terminates; fact!
andrew j langham

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Aug 1, 2010
 

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Mitochondria with ref’ to HIV
The HIV virus enters the body using rogue testosterone; in blood or semen;
Rogue corrupted testosterone confuses RNA and ultimately corrupts DNA; ie #
(so called reverse transcription);
Rev pol gag tat sequences are derived from RNA and form HIV proteins such as
Glycogen protein 120 gp 41 etc ’via STAT signalled RAR retinol acid RXR acid annexed to immunoglobulin docking; especially on fc receptors upon B memory cells;
NOTE: it is mitochondria RNA DNA that is of a bacteria matrix design and it is this complex matrix that mixes into the main cell DNA which then causes the multiplicity of combinations of rev pol gag and tat HIV protein sequences; note; most drugs like reverse transcriptase only target RNA and DNA
NOTE; NOT MITROCHONDIRA RNA &DNA; as it needs to do;

HIV RNA gaining access into mitochondria can compromise mitochondrial function,
so that rogue testosterone esterifiction can actually link further as a sort of rogue peptide which 66 amino digits long and can cross the brain matrix barrier causing brain cancer and dementia’s;

conclusion; a vaccine is needed, in order to prevent;- note; ‘only’ testosterone that is adulterated ie estrified with Hiv+pylori =(rogue testosterone) from causing HIV transfer from cell to cell and person to person, via the mitochondria RNA cross mixing with normal cell RNA assisted by rogue testosterone acting as a latch key and metamorphic infiltrator; which multi-plexes rev, pol ,gag ,tat, genes and subsequently rev pol gag tat, rogue hiv proteins;
andrew j langham

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Aug 1, 2010
 

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Mitochondrial dysfunction is getting more and more attention as an underlying mechanism of chronic fatigue syndrome and is very apparent in all aids patients;
andrew j langham

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Aug 1, 2010
 

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Primosomes are at least 7 nucleoprotein assemblies that activate DNA replication strand division; Their primary role is to recruit the replicative helicase onto single-stranded DNA. The "replication restart" primosome, defined in Escherichia coli,and pylori bacta is involved in the reactivation of arrested replication fork patterns. Binding of the PriA protein to a Y fork pattern; DNA triggers its assembly. PriA is conserved in bacteria, but its primosomal partners are not. In Bacillus subtilis, genetic analysis has revealed three primosomal proteins, DnaB, DnaD, and DnaI, that have no obvious homologues in E. coli. Interestingly, they are involved in primosome function both at arrested replication forks and at the chromosomal origin. Our biochemical analysis of the DnaB and DnaD proteins unravels their role in primosome assembly. They are both multimeric and bind individually to DNA. Furthermore, DnaD stimulates DnaB binding activities. DnaD alone and the DnaD/DnaB pair interact specifically with PriA of B. subtilis on several DNA substrates. This suggests that the nucleoprotein assembly is sequential in the PriA, DnaD, DnaB order. The preferred DNA substrate mimics an arrested DNA replication fork with unreplicated lagging strand, structurally identical to a product of recombinational repair of a stalled replication Y fork pattern; Note Hiv pylori estrification ie 'corrupted testosterone' confuses this process substantially;
andrew j langham

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Aug 1, 2010
 

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Note; as hiv establishes within the patient the liver cells come under attack releasing oleic acid or similar types of glycogen clumps of unsaturated fatty acids which inhibit testosterone by blocking the action of esterase upon cholesterol, within the the action of the entire endocrine system, important: please note this is a significant clue in the hiv histology or cycle of HIV percularity events; because it helps explain not only but one of the reasons for a reduced levels of testosterone but importantly explains why esterase is unable to break up corrupt Hiv testosterone esters that are thought to disrupt cell transcription thus producing Hiv proteins directly via incorrect STAT signalling;
andrew j langham

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Aug 1, 2010
 

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Note; as hiv establishes within the patient the liver cells come under attack releasing oleic acid or similar types of glycogen clumps of unsaturated fatty acids which inhibit testosterone by blocking the action of esterase upon cholesterol, within the action of the entire endocrine system, important: please note this is a significant clue in the hiv histology or cycle of HIV percularity events; because it helps explain not only but one of the reasons for a reduced levels of testosterone but importantly explains why esterase is unable to break up corrupt Hiv testosterone esters that are thought to disrupt cell transcription thus producing Hiv proteins directly via incorrect STAT signalling;
andrew j langham

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Aug 4, 2010
 

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All PPARs heterodimerize with the retinoid X receptor (RXR) and bind to specific regions on the DNA of target genes. These DNA sequences are termed PPREs (enzyme control peroxisome proliferator hormone response elements). The DNA consensus sequence is AGGTCAXAGGTCA, with X being a random nucleotide. In general, this sequence occurs in the promotor region of a gene, and when the PPAR binds its ligand, it is then the corrupted Hiv transcription of varius target genes are increased or decreased, depending on the amount of Hiv proteins distributed throughout the entire anatomy ; The corrupted RXR also forms a heterodimer with a number of other receptors RAR etc;

The function of PPARs is modified by the precise shape of their ligand-binding domain induced by ligand binding and by a number of co-activator and corepressor proteins, the presence of which can stimulate or inhibit receptor function, respectively; note; this is why there isvery often a long delay before patients exhibit Hiv symptoms;

Endogenous ligands for the PPARs include free fatty acids and eicosanoids which when pylori toxin is present may form bizarre hormone estrification, of which esterase may be absent or non-effective; due to Hiv;

note; PPAR&#947; is activated by PGJ2 a type of prostaglandin hormone, ref Hiv is always elevated; In contrast, PPAR&#945; is activated by leukotriene B4. PPAR&#947; activation by agonist RS5444 often inhibit anaplastic thyroid cancer growth; and many myelomas of various kinds;

Note; free retonoic acids when reverse transcripted become alleled to glycogen substrates & form random STAT signalled estrified gp 160 gp120 gp41 proteins carried by cell peroxsomes especially ref 'Hiv; which then, these Hiv proteins act as cataylst promoters for Hiv proteins,as well as all other proteins inside the nucleus of all cells and proliferate; this then causes imbalance of cell production; example; carrier peroxsomes enzymes, do not then remove excess potassium and peroxides so cell apoptosis ensues; consequently Hiv proteins are released along with corrupted testosterone/estradiol with attached Hiv esters; which further proliferate Hiv virions of which contaminate other cells;
andrew j langham

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#18
Aug 4, 2010
 

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alleled Hiv gag protein trafficking defect in which AGT is addition may lead to direct Hiv tubular and enzyme damage. mistargeted from peroxisomes to mitochondria;
andrew j langham

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Aug 4, 2010
 

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eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids such as omega-3 & omega-6 they are very much affected by Hiv;
example; corruption of prostaglandin,causing over production; eicosaoidal signalling can result in incorrect first line bacterial histomine response and macrophage's being sustained, when should be terminated, ie when infected by host virions; eichosanoids are not easily detectible and some only last 20 micro-seconds others last for several hours; aspirin can control the production of eicosanoids has a calming effect and down grades production by controlling sensory nerves;
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Aug 4, 2010
 

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gamma interferon macrophage activating factor—stimulates macrophages to produce nitric oxide. The source of interferon-gamma can be CD4+ T cells, CD8+ T cells, natural killer cells, B cells, natural killer T cells, monocytes, macrophages, or dendritic cells. Nitric oxide because of its toxicity, kills viral microbes near the macrophages and within the macrophage cell actvation glomeration; Activated macrophages produce and secrete tumor necrosis factor. This cytokine—a class of signaling molecule— interluekin 12 kills cancer cells and cells infected by viruses, and helps to activate the other cells of the immune system; however when infected by Hiv proteins whether te cd4 cells are signalling correctly or not, or the ccorreect cytokine cascades are functioning correcty or not it is the termination of the macrophages when infected with Hiv proteins it regognises the hiv proteins as antigensand ingests them but does not recognise Hiv corrupt testosterone esters and so consequently the corrupt testosterone esters continue to infect as they are not recognised and so consequently the macrophage cellular complex niether terminates its life cycle or extinguishes the Hiv virions; this is the main reason Hiv persists within the human and mammalian anatomy; Fact;
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Aug 5, 2010
 

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Testosterone acts non-genomically, i.e. through surface receptors, on murine T cells and 'macrophages's especially, which becomes evident as a rapid rise in the intracellular free Calcium ions). In T cells, this rise reflects predominantly influx of extracellular Calcium ions, while it is predominantly due to release of Ca(2+) from intracellular Ca(2+)-stores in macrophages, conclusion testosterone plays an important role as regard T cell macrophages are concerned; consequently Hiv patients are always deficient as regards macrophage on station alerting defence action due too testosterone levels being always at low levels in HIV PATIENTS and note; the testosterone is always corrupted by pylori toxin Hiv esters; Fact; consequently all cells within the anatomy become corrupted by Hiv virions;
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Aug 5, 2010
 

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gamma interferon macrophage activating factor—stimulates macrophages to produce nitric oxide. The source of interferon-gamma can be CD4+ T cells, CD8+ T cells, natural killer cells, B cells, natural killer T cells, monocytes, macrophages, or dendritic cells. Nitric oxide because of its toxicity, kills viral microbes near the macrophages and within the macrophage cell activation glomeration; Activated macrophages produce and secrete tumor necrosis factor. This cytokine—a class of signaling molecule— interluekin 12 kills cancer cells and cells infected by viruses, and helps to activate the other cells of the immune system; however when infected by Hiv proteins whether the cd4 cells are signalling correctly or not, or the correct cytokine cascades are functioning correctly or not, it is the termination of the macrophages when infected with Hiv proteins, it regognises the hiv proteins as antigens and ingests them, but does not recognise Hiv corrupt testosterone esters and so consequently the corrupt testosterone esters continue to infect, as they are not recognised and so consequently the macrophage cellular complex neither terminates its life cycle or extinguishes the Hiv virions; this is the main reason Hiv persists within the human and mammalian anatomy; Fact;

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