First Documented Case of Child Cured of HIV

Mar 4, 2013 Full story: www.sciencedaily.com 17

Deborah Persaud of Johns Hopkins University today described the first documented case of a child being cured of HIV.

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Since: Mar 09

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#1 Mar 4, 2013
The virus goes dormant and hides in organs and bone marrow.

“Equality First”

Since: Jan 09

St. Louis, MO

#2 Mar 4, 2013
snyper wrote:
The virus goes dormant and hides in organs and bone marrow.
I heard this reported on radio this morning, and also read an article in the paper. Neither one said anything about it hiding in organs and bone marrow. If that is true, I would assume that the doctors will continue to monitor the child.

Since: Mar 09

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#3 Mar 4, 2013
RalphB wrote:
<quoted text>
I heard this reported on radio this morning, and also read an article in the paper. Neither one said anything about it hiding in organs and bone marrow. If that is true, I would assume that the doctors will continue to monitor the child.
One hopes. What isn't mentioned is "Seral Conversion" which assists the early medications.

Still, the only truly proven cure to date is the Berlin case using complete destruction of the immune system and bone marrow transplantation.

“Equality First”

Since: Jan 09

St. Louis, MO

#4 Mar 4, 2013
snyper wrote:
<quoted text>
One hopes. What isn't mentioned is "Seral Conversion" which assists the early medications.
Still, the only truly proven cure to date is the Berlin case using complete destruction of the immune system and bone marrow transplantation.
I tried looking up "Seral Conversion". No hits. I did find this:

SERO CONVERSION /se·ro·con·ver·sion/(-con-ver´ zhun) the change of a seronegative test from negative to positive, indicating the development of antibodies in response to immunization or infection.

Of course I don't really get that either. Can you expand?

Since: Mar 09

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#5 Mar 4, 2013
RalphB wrote:
<quoted text>
I tried looking up "Seral Conversion". No hits. I did find this:
SERO CONVERSION /se·ro·con·ver·sion/(-con-ver´ zhun) the change of a seronegative test from negative to positive, indicating the development of antibodies in response to immunization or infection.
Of course I don't really get that either. Can you expand?
Sorry. I misspelled.

Infants are born with a very limited immune system. This limits the ability of HIV to become entrenched in immune cells during prenatal exposure ... mostly because there aren't very many, and the systems which produce them aren't actually up and running yet. Without a significant population of the virus, entrenchment within the various organs and tissues where HIV "likes to hide" has had very little time to occur. Seroconversion hasn't actually happened yet, so over-saturating the system with antivirals should eliminate the virus. Treatment need to be intensive and longterm because the kidneys take months to get up to speed in the best of conditions, and will have difficulty filtering and excreting the suppressed virus and virus particles.

Not much research has been done to determine if the HIV can reassemble itself given sufficient particles within a living host organ. Some viruses can, given the right conditions.

“Equality First”

Since: Jan 09

St. Louis, MO

#6 Mar 4, 2013
snyper wrote:
<quoted text>
Sorry. I misspelled.
Infants are born with a very limited immune system. This limits the ability of HIV to become entrenched in immune cells during prenatal exposure ... mostly because there aren't very many, and the systems which produce them aren't actually up and running yet. Without a significant population of the virus, entrenchment within the various organs and tissues where HIV "likes to hide" has had very little time to occur. Seroconversion hasn't actually happened yet, so over-saturating the system with antivirals should eliminate the virus. Treatment need to be intensive and longterm because the kidneys take months to get up to speed in the best of conditions, and will have difficulty filtering and excreting the suppressed virus and virus particles.
Not much research has been done to determine if the HIV can reassemble itself given sufficient particles within a living host organ. Some viruses can, given the right conditions.
Thanks. We learn something every day. Now, the trick is to remember it.
Nelson

Netherlands

#7 Mar 4, 2013
Now if they can only find a cure for homosexuality we'd be golden!

“Live and let live”

Since: Apr 08

New Orleans

#8 Mar 4, 2013
snyper wrote:
<quoted text>
Sorry. I misspelled.
Infants are born with a very limited immune system. This limits the ability of HIV to become entrenched in immune cells during prenatal exposure ... mostly because there aren't very many, and the systems which produce them aren't actually up and running yet. Without a significant population of the virus, entrenchment within the various organs and tissues where HIV "likes to hide" has had very little time to occur. Seroconversion hasn't actually happened yet, so over-saturating the system with antivirals should eliminate the virus. Treatment need to be intensive and longterm because the kidneys take months to get up to speed in the best of conditions, and will have difficulty filtering and excreting the suppressed virus and virus particles.
Not much research has been done to determine if the HIV can reassemble itself given sufficient particles within a living host organ. Some viruses can, given the right conditions.
HIV does not reassort. Because it writes itself into the genome, it sometimes undergoes anti-genic shift and drift when read out of the genome via tramscrption factors, but the genetic material cannot recombine freely, as is the case with the flu. A reasonable hypothesis for why antiretrovirals might prove effective at curing HIV in some infants is that young children have much more active DNA repair mechanisms than adults. If the virus cannot store any backup copies of itself (in the DNA of bone marrow cells mostly), then antiretrovirals could effectively eliminate it.

Since: Mar 09

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#9 Mar 4, 2013
Josh in New Orleans wrote:
<quoted text>
HIV does not reassort. Because it writes itself into the genome, it sometimes undergoes anti-genic shift and drift when read out of the genome via tramscrption factors, but the genetic material cannot recombine freely, as is the case with the flu. A reasonable hypothesis for why antiretrovirals might prove effective at curing HIV in some infants is that young children have much more active DNA repair mechanisms than adults. If the virus cannot store any backup copies of itself (in the DNA of bone marrow cells mostly), then antiretrovirals could effectively eliminate it.
Any data on the mechanism of facilitation in marrow cell invasion?

Research biochemist?

“Equality First”

Since: Jan 09

St. Louis, MO

#10 Mar 4, 2013
Wow, this thread went over my head some time ago. I guess from here on out I will just read and learn.

Since: Mar 09

Location hidden

#11 Mar 4, 2013
RalphB wrote:
Wow, this thread went over my head some time ago. I guess from here on out I will just read and learn.
Well, a good place to start is to know that the immunodeficiency viruses (SIV, HIV, EIV, BIV, FIV) are kinds of retroviruses which cannot replicate themselves, but rewrites the DNA of the host to do that job. Nasty little opportunists.
Fred

Alexandria, VA

#12 Mar 4, 2013
Nelson wrote:
Now if they can only find a cure for homosexuality we'd be golden!
Agree with you 150%

“Equality First”

Since: Jan 09

St. Louis, MO

#13 Mar 4, 2013
snyper wrote:
<quoted text>
Well, a good place to start is to know that the immunodeficiency viruses (SIV, HIV, EIV, BIV, FIV) are kinds of retroviruses which cannot replicate themselves, but rewrites the DNA of the host to do that job. Nasty little opportunists.
Believe it or not, that much I knew. Of course, that's like saying I know 1 + 1 equals 2, while the rest of the class is into Physics.

“Live and let live”

Since: Apr 08

New Orleans

#14 Mar 4, 2013
snyper wrote:
<quoted text>
Any data on the mechanism of facilitation in marrow cell invasion?
Research biochemist?
http://europepmc.org/abstract/MED/2460922/rel...

Since HIV infects Tcells, and the production line begins in the marrow, the virus also infects progenitors. It can infect neurons too, so a diminished Tcell count is not likely to prevent seroconversion. Besides, the infection in this child was already full blown.

I'm not a biochemist, but I am a data scientist. DNA is data, so I have an idle academic interest in the subject.

“Live and let live”

Since: Apr 08

New Orleans

#16 Mar 5, 2013
RalphB wrote:
<quoted text>
Believe it or not, that much I knew. Of course, that's like saying I know 1 + 1 equals 2, while the rest of the class is into Physics.
As far as learning something new goes, everyone has to start somewhere. Not more than a decade ago I would have fainted at the proposition of building and working on some of the data systems I do now. Looking back on it, I simply started by learning a little bit here and a little bit there. Eventually, and with the help of college, I gained a robust knowledge about computer science. The same applies to any academic field- it takes time to learn it.
Vaccine Started

Winnipeg, Canada

#17 Mar 5, 2013
It started either accidently or purposely through vaccine contamination.

“Equality First”

Since: Jan 09

St. Louis, MO

#18 Mar 6, 2013
Josh in New Orleans wrote:
<quoted text>
As far as learning something new goes, everyone has to start somewhere. Not more than a decade ago I would have fainted at the proposition of building and working on some of the data systems I do now. Looking back on it, I simply started by learning a little bit here and a little bit there. Eventually, and with the help of college, I gained a robust knowledge about computer science. The same applies to any academic field- it takes time to learn it.
True enough. I sometimes amaze myself at the things I have learned since I was 50. That's about the age that I reached the pinnacle of my career, and then had the time to spend learning new things.

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