Krill Oil considered to Prevent and Treat Heart Disease
Posted in the Heart Disease Forum
#1 Feb 9, 2012
The AJCN states, Habitual “Consumption of 250-500 mg DHA and EPA per day, from either dietary or supplement sources should be part of management for primary prevention of Cardio Heart Disease death. It’s important also to note that consumption after a coronary event is said to also reduce risk of Cardio Heart Disease Death.
I feel it important to state that n-3 fatty acids (DHA and EPA) should not be considered as a single therapy in prevention of and/or treatment for cardiovascular disease. Rather, higher n-3 fatty acid intakes should be considered as a biologically active partner to lifestyle changes and to medications that are used to prevent and treat cardiovascular disease.
Why would this be important?
EPA and DHA are both extremely unsaturated and, as we all know, the greater the degree of unsaturation, the greater the tendency to go rancid, hence fish burp’s. When these oils go rancid they don’t go from being healthful to simply becoming neutral, they actually convert to harmful oxidized fats called lipid peroxides.
Lipid peroxides can (and do) start free radical forces that can damage fatty cellular membranes. At the very least lipid peroxides consume the body’s storage of vitamin E and other antioxidants in order to neutralize itself, leaving the body short of many of its natural defenses.
What I understand being said is when you are consuming rancid oils or oils that have long started the oxidation process we are actually affecting the bodies abilities to fight against any and all inflammatory diseases.
So many of us believe that all krill oils and fish oils are the same where in fact they are all very different.
There is a general consensus, consistently in the Am J Clin Nutr agreeing that marine omega-3's are considered to be the most effective natural means of lowering elevated plasma triacylglycerol concentrations, Krill oil being the best because of its natural phospholipid form.(pubmed). These elevated plasma triacylglycerol concentrations are the cause of coronary heart disease. Mortality risks are also attributed to reduced arrhythmic death in the primary prevention setting and after an initial cardiac event.
In the Am J Clin Nutr, there were 2 important cardiovascular outcome trials that stood out as important influences, GISSI –Prevenzione Study and JELIS- Intervention Study.
GISSI: The study showed patients had a significant reduction of 21% in total mortality and a 45% reduction in sudden death by study end with n–3 FA treatment.
JELIS: tested the hypothesis that the addition of 1.8 g/d highly purified EPA to statin therapy can reduce the incidence of major cardiovascular events in Japanese patients with hypercholesterolemia.
All patients were given low-dose statin therapy and continued to consume a diet rich in omega-3 Fatty Acids. At the end of 54 months, the incidence of major coronary events was reduced 19%(95% CI: 5–31%; P = 0.011), including the composite endpoint of nonfatal MI, coronary artery disease death, unstable angina, and revascularization procedures. The incidences of unstable angina and nonfatal coronary events were significantly reduced by 14%(P = 0.014) and 19%(P = 0.015), respectively, but the incidences of sudden death and coronary death were unchanged.
The degree of triacylglycerol concentrations reduction depends on both the baseline triacylglycerol concentration and the dose of EPA/DHA used.
It’s important to state that one of the most important effective uses of high dose omega-3's is in combination with other lipid-lowering drugs. Higher omega-3 intakes should be considered as a biologically active partner to lifestyle changes and to medications that are used to prevent and treat cardiovascular disease.
Omega-3 Krill Oil is particularly attractive in combination therapy because of their lack of side effects and lack of drug interactions.
Vital HP krill oil- most effective source of omega-3's. Ensuring the highest quality available.
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