New safety concern related to antipsychotic treatment
Overall, antipsychotic medications are reasonably effective, and fairly well tolerated treatments for mood and psychotic disorders.
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#1 Dec 2, 2009
How Zyprexa makes you Fat
Study out on Eli Lilly Zyprexa causing diabetes
Anti-Psychotic Drugs (Zyprexa) Change Metabolism
Based on these findings we concluded that male rats treated with olanzapine experienced an early disruption of energy metabolism.
In the study 18 male rats were randomly assigned to one of three groups:(1) those receiving the conventional antipsychotic drug haloperidol (HA); (2) those receiving the atypical antipsychotic drug olanzapine (OL); or (3) the control (CO) group which did not receive either drug.
The medicines were given in food for a period of six weeks. Female rats were excluded to eliminate bias in the study since antipsychotic-induced weight gain in female rodents is likely related to an interaction of the drugs with estrogens.
Testing after four weeks found that the concentration of blood sugar (as glucose) was higher in OL rats (0.87 g/l) than in CO rats (0.75 g/l) and the levels increased more rapidly after a glucose meal. Testing six weeks later found fasting blood sugar levels continued to rise in OL rats (1.46 g/l vs. 1.25 g/l in CO rats) while the level of lipids (fats) in the blood was similar for both groups.
Although there was no difference in body weight gain or food intake, the proportion of fat stored in the abdominal cavity was higher in OL rats (1.63%) vs. CO rats (1.44%).
The HA rats did not vary in any way with the control group at any time. They exhibited a lower blood sugar level after a glucose meal and a lower proportion of intraabdominal fat store (1.44%) than OL rats.
Senior study author Dominique Hermier said,Based on these findings we concluded that male rats treated with olanzapine (Zyprexa) experienced an early disruption of energy metabolism. This was a result of the fat tissue we observed and the impairment in blood sugar regulation which are both associated with metabolic syndrome and subsequent risk of diabetes.
Source: American Physiological Society
Zyprexa,as well as the other atypical antipsychotics, are being prescribed for children, even though this is an unapproved, off-label use. Eli Lilly has been charged in allegedly pushing the drug for children in more than one state.
A report by Dr. Cooper at Vanderbilt University states that 2.5 million children are now taking atypical antipsychotics. Over half are being given them for Attention Deficit Hyperactivity Disorder. Perhaps it is statistics like these that caused the FDA to finally require warnings on the labels of the ADHD drugs.
The use of atypical antipsychotics for children should be banned.
Daniel Haszard Zyprexa Whistle blower
#3 Aug 1, 2013
I took Klonopin and Paxil for 15 years to treat my anxiety disorder. I had to detox from the Klonopin this past spring. I got off the Klonopin and switched my Paxil to Lexapro (sex side effect issue). I am also a recovering alcoholic. My doctor did not want me on Benzo's anymore (says it increased alcohol cravings). I stayed on Lexapro only for 9 months, but my anxiety came back strong on just the Lexapro alone. I almost resorted to taking Xanax before I switched doctors. My new doc gave Zyprexa from http://z-olanzapine.com a chance. I am on my 7th day and I haven't felt this "normal" in 5 years. I take 5mgs at night and it has ended the "chatter" in my head, and removed my anxiety. Great medicine so far.
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