Role For Seroquel In The Treatment Of Bipolar Depression

Full story: Medical News Today

Category: Bipolar News Article Date: 08 Jul 2005 - 11am Published data shows Seroquel is efficacious in treating core symptoms of bipolar depression , including the reduction of suicidal thoughts - It is ...

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mike howard

United States

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#1
Jul 30, 2006
 
It's time America wakes up to the truth about drugs like Seroquel. Look at the data from every states poison control agency and see the volumes on suicides from overdoses of Seroquel. look at the FDA data on Seroquel and see where Astrazeneca hides the suicides by calling them "accidental overdoses" or "accidental injuries". The comparator drug used in Astrazenecas approval studies was at doses over what the FDA recommends for severe schizophrenia. Astrazeneca has conducted Seroquel studies and has failed repeatedly to publish those studies showing their drug caused harm. They only publish the studies where Seroquel in their opinion has an advantage.
Jeroen

Oudenaarde, Belgium

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#2
Jun 5, 2007
 
hi there, you are right,

but those people dont care

it took seroquel as prescribed, and it turned me into a zombie, non human, almost dead person, and i wasnt even psychotic, those doctors must be stopped, lot of people died or commited suicide as i am withdrawing from it now, it is nightmare, heavy sweating, feeling stupid and dead,
AMM

Des Plaines, IL

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#3
Jun 7, 2007
 
Seroquel was approved for ACUTE bipolar mania in 3 to 12 week clinical trials, and for bipolar depression in the study in this forum. Long term treatment of bipolar patients has not been studied in clinical trials, yet this is how it is generally used. The study claims that suicidal ideation is reduced during short term trials on depressed bipolar patients. Based on this, my doctor claims that Seroquel is the only antipsychotic approved for bipolar depression. The truth is that in the short term, Seroquel masks feelings of sadness, anxiety and other moods that lead to suicidal ideation. In my experience, Long term use of Seroquel led to 3 periods of suicidal ideation. The constant lethargy and general crappy feeling, along with substantial (about 50 pounds) weight gain, sexusal disfunction, bladder control problems, lack of willpower and initiative, and other side effects led to seriously considering suicide 3 times during the 5 years I took Seroquel. Fortunately, the third time I called a strikeout for Seroquel, quit cold turkey and feel 1000% better now. The rebound insomnia and wild emotional swings have been difficult and have clearly shown what Seroquel is. ALL of the side effects cleared up within a month of quitting and I now consider suicidal ideation another side effect of this powerful, dangerous and dependance for sleep drug. After 7 weeks off Seroquel I still have the urge to take Seroquel at bedtime to get to sleep.
AMM

Des Plaines, IL

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#4
Jun 7, 2007
 
The role of Seroquel in the treatment of bipolar disorder is so that no real treatment occurs. The hospitals and clinics just push more and more crap like Seroquel, Risperdal and Zyprexa like they are some kind of magic bullets. Patients are turned into fat, lazy zombies that are easier to deal with. Most patients get no exercise, and head strait for the junk food vending machines after their so called cooking skills class. The only reason they go outside is to smoke. The average life expectancy is only 51, so that makes them really easy to deal with.
Zoompad

Coventry, UK

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#5
Jun 8, 2007
 
I am a institutional child abuse and rape victim and I have been bullied into taking virtually every form of these drugs for over 30 years. I have struggled to find a councellor.

Something inside me kept me from taking any of this stuff. I had an uneasy feeling, that something wasn't right.

Now I know that I was right to refuse these drugs. I have seen what they have done to so many other people. It's not a pretty sight.

I found self help groups very good, and read some books on helping people to get through acute depression and child abuse. I have to warn you, I read one terrible book, and I realise now that it had been written by the same people who support False Memory Syndrome. There are paedophile psychologists who want to cover up institutional child abuse.

But self help groups are good. Talking about depression to other people is a very good thing. And some people are helping other people on these Topix forums.

But I am so glad I resisted the bullying doctors who tried to force me to take their drugs. I do not cry much these days, but I used to be always crying, day and night. It is wonderful to be free of the misery and the fear. Absolutly wonderful!
AMM

Tinley Park, IL

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#6
Aug 8, 2007
 
The psychiatrists use every tactic to trick their patients into taking medications like Seroquel, Risperdal and Zyprexa, almost always to the patients detriment. Most doctors will give patients several options when a major treatment decision is made, and then allow the patient to make the final decision. Psychiatrists virtually never do that, they choose several powerful and dangerous medications and then expect the patient to simply accept their expert decision. The psychiatirists "threaten" the patients with statements that the patients will become nonfunctional or be hospitalized if they don't take the medications, while downplaying the severe risks and troubling side effects. The Psychiatrists claim that the fact that mental hospital populations have plunged and most of the former patients are living in the community leading normal lives proves the effectiveness of their medications. This is exactly the opposite of what has actually happened. Most severely mentally ill patients that would have been hospitalized 50 or 100 years ago are in one of the following places;
Jail or prison
Living on the street
Living in miserable adult or nursing homes
Cemetery
Real treatment suffers as most patients don't have adequate access to psychotherapy, and most of those that do don't have the motivation to pursue adequate psychotherapy due to their medication induced apathy. Even when all a hospitalized patient has to do is walk 20 feet to participate in a group, most just sit or lie around near a blaring TV. In a way, the psychiatrists appear to be acting as if they are on the defensive, by keeping nearly total control over their patients and even the psychologists and social workers, any dissent is quashed. An example of this is a psychologist can't even hand a medication sample to a patient even when acting directly under the psychistrist's orders.
AMM

Tinley Park, IL

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#7
Aug 15, 2007
 
Seroquel has been approved by the FDA for the treatment of bipolar mania and depression, based on clinical trials conducted by AstraZeneca employees and affiliated researchers. Based on a variety of sources ranging from personal experiences to observations of other bipolar patients to internet postings to the observations of the handful of opposing experts, my contention is that not only is Seroquel dangerous and ineffective, it is counterproductive.
When I was first diagnosed with a mental illness, and then bipolar 8 years ago, I wanted to believe that a biochemical imbalance or structural brain defect was to blame. Although I was skeptical of medication at first and researched each medication before starting it, weighing the benefits, costs and risks, I believed that medications really could help and that the right medication could cure my illness. Thes beliefs continued until a few months ago when the side effects of Seroquel were beginning to lead to a third round of suicidal ideation, at which time I quit Seroquel cold turkey.
Case histories of patients who died from overmedication are posted at mindfreedom.org , and my case is very similar to these terrible outcomes in many ways. Increased patient aggression is responded to with an increase in dosage or number of medications, yet the aggression usually continues.
AMM

Tinley Park, IL

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#8
Aug 15, 2007
 
In early 2004 I was under multiple stressors, and was taking Seroquel and Depakote. In hindsight, I was manic, doing extremely aggressive and dangerous things and getting into trouble. In mid-May 2004 I started to become depressed, and as is my usual pattern, drowned my sorrows by binge eating. I developed nausea and vomiting from the binge eating, and stopped taking the Seroquel and Depakote to deal with the physical symptoms. The following day I passed by where an 11 year old boy had just been struck by an express train. Considering how I was feeling to begin with, and the withdrawl effects of the medications (which I didn't recognize until recently), seeing his bicycle pinned under the locomotive's fuel tank was extremely distressing. For the next 2 days I became increasingly irritable, until the outbursts were becoming far too dangerous. I would think about my problems, and without any outside provocation, instantly go into a rage, thinking why shouldn't I kill myself and those around me. Recognizing this extremely dangerous situation, I made the decision, alone and without prompting by anyone, to go to my outpatient clinic, fully realizing this would mean a hospitalization. My attitude was that it was far too dangerous to be outside the hospital where a wide variety of methods to kill myself or others was available. My attitude was it would be neccesary to spend a few days or weeks in the hospital, where I would be safe and could recieve treatment, until I could safely function outside again. For the first 8 hours, throughout the admissions process, I was trying to be calm (considering my mixed episode state) and was very cooperative with the hospital staff during the admissions process. Things were going as smoothly as could be expected in the situation, I was looking forward to talking with other patients and staff and attending groups. At 9pm May 28, 2004 I took a 400mg dose of Seroquel. Big Mistake.
AMM

Tinley Park, IL

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#9
Aug 15, 2007
 
The next morning I woke up in the usual Seroquel induced fog, feeling crappy and emotionless. Unlike the previous day when I had a determination to solve my problems, Seroquel left me apathetic and without the motivation and willpower necessary to control my anger. My memory of what followed is minimal at best, and most of the following information is based on my chart. During lunch I suddenly and without warning felt overwhelmed by my situation. Nothing unusual was happening at the table, so the only thing others saw was me throwing a bowl of soup across the table. This was referred to as "internal stimuli", what the staff couldn't see was how the internal stimuli developed and how Seroquel made it uncontrollable. A confrontation developed with a patient who was struck by the soup, which nearly escalated into a chair throwing fight. Security was called, and I agreed to take Haldol. Next big mistake.
prosandcons

Dover, NJ

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#10
Aug 15, 2007
 
ive been on various psych meds for 7 years -i am 19-. i was on as many as 9 psychotropic medications at one time. they were to numb me until i couldnt feel. what i was feeling was unbearable, if id had to feel like that much longer, THAT would have driven me to suicide.
those medications, all 9 of them, allowed me to finish my sr. year of high school after 3 months in the hospital during the middle of my sr. year.

im now only on seroquel, and i absolutely LOVE it. i only take 100mg/night. i take up to 300 or 400 a night if i need it.
ive gone off seoquel, ive gone without meds for several months. i dont care if it makes me fat. or if it kills me early (which so far its done neither.) if it can make the years that i do live better and worth living, so be it. ill take 10 good/great years over 20 or more years that are bad.

yes; drs should use more discrescion in who they give what drugs. but just because a drug didnt work for you doesnt mean the drug is evil.
AMM

Chicago, IL

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#11
Aug 16, 2007
 
prosandcons wrote:
ive been on various psych meds for 7 years -i am 19-.
im now only on seroquel, and i absolutely LOVE it. i dont care if it makes me fat. or if it kills me early (which so far its done neither.) if it can make the years that i do live better and worth living, so be it. ill take 10 good/great years over 20 or more years that are bad.
prosandcons-
Your attitude is doing a good job of providing one of the few pieces of evidence that is missing from my mountain of evidence that Seroquel is dangerous and ineffective. When my doctor or therapist says "I know so many patients that have benefited greatly from medications", I don't have a response because of the small number of cases that I a familiar with.
Starting a 12 year old on antipsychotics and building up to a cocktail of 9 medications while still a teenager shows the reckless arrogance of the psychiatric profession. Few if any of these medications have been approved for children or teenagers, giving 9 is extremely dangerous. Perhaps Seroquel seems tolerable only when compared to the devastating effects of being on 9 medicatons. Your attitude toward the future looks like a combination of being a teenager, thinking I am invincable, and being under Seroquel's spell. It is easy to say when you are 19 that "I dont care if I only live to 29" and "I don't care if it makes me fat" when you have never been more than 100 pounds overweight. Your statement "better and worth living" sounds like a slogan put into your mouth by your doctor, who gets advice on how to convince patients to take Seroquel from AstraZeneca drug reps. I question both the effectiveness of Seroquel in controlling your symptoms, beyond Seroquel's sedating effect and the placebo effect, and the real tolerability of Seroquel's side effects for you. I took Seroquel for over 5 years, not realizing how many of the problems that I considered just something a 46 year old should expect, were actually Seroquel side effects. While on Seroquel, my basketball skills deteriorated so much that I didn't even practice once for years. This morning I got a great workout practicing basketball from 5:45 to 7:00. I also have seen patients at my clinic clearly suffering severe side effects, yet they are in total denial that their serious problems are being caused by their medications. You do care if you get fat and die in 10 years, your doctor probably doesn't and AstraZeneca sure doesn't.
AMM

Chicago, IL

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#12
Aug 16, 2007
 
After the chair incident, I was quickly placed on 7 medications - Seroquel, Haldol, Thorazine, Ativan, Klonopin, Depakote and Trileptal. This combination left me so heavily sedated that I have absolutely no memory of the following week. Although I have no memory of taking the medications, I assume that I was unable to realize what I was taking and protest or refuse the medications. I had completely lost control of my body and mind. The effects were devastating, quoting from the chart during that week, "pt came out of his room with unsteady giat, appeared very sedated and crumpled down in hallway to the floor" "arousable but very sedated" "too tired to talk" "pt. extremely sedated but responsive" "too tired to cooperate, barely able to open eys" "unable to answer questions due to lethargy" "he did not know the towels in his private room were for him to use" "speech: non-pressured, slow rate, only answers questions in barely audible volume" "tired now" "tongue is dry and covered by a graham cracker" "he is lying in bed clearly fatigued, not making any sense, speaking about "connecting dots 1-2-3" pt may be experiencing Thorazine induced anticholinergic delerium and so will give 5 mg Haldol rather Thorazine" "(after 1 week)Pt has not showered since his arrival, he is sleeping in the same clothes in which he arrived. My blood pressure fell as low as 64/45 with apulse of 131 versus my normal 130/85.
With this near-death blood pressure and extreme sedation from a cocktail of antipsychotics, you might assume my agression was gone, wrong.
Whenever I had enough energy to speak something intelligable, what I said was usually agressive. I threw a glass of water the first time I was able to make it to the dining room, and repeatedly hit my fist on the wall. What is absent from the chart speaks even more than what is in it. No curiousity about my situation, no attempt to do something to help my situation, the attitude of a few days earlier of confronting my illness was comletely gone, I didn't even request for food and water, the staff had to make sure I got enough water. These are extreme levels of the side effects of antipsychotics, yet where is the "antipsychotic" theraputic effect? So what happened when the medications were reduced?
AMM

Chicago, IL

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#13
Aug 16, 2007
 
As the medications were reduced, the anger became more managable. When another patient made a nasty comment about how I was drinking juice shortly after dosage reduction began, I threw the juice at him. A few days later the same patient commented "you have to finish 8th grade to use the remote", I responded with "I finished college before you were out of diapers". Also notice that the specific comments were remembered at least long enough to report them to staff. As Thorazine and Haldol were eliminated, so too was any further agressive outbursts. The pattern seems to be clear, the medication does nothing to reduce the real level of symtoms, rather to sedate so that symptoms appear to be reduced. The doctors always responded to agressive behavior with increased medication, even when the level of sedation was extreme, appearantly without considering that the medications may actually be making the agression worse.
The outcome of the hospitalization would have been completely different if I hadn't resumed taking Seroquel. I would have interacted with staff and other patients, attended groups, and would have been discharged in a fraction of the time. Although this experience can't be considered representative of what effects the medications would have on most or all other patients in other situations, it leaves me seriously considering if there is such a thing as "theraputic antipsychotic effect" from Seroquel and other antipsychotic medications.
I could have gone off Seroquel due to the side effects, and if I hadn't found extensive evidence that Seroquel is dangerous and ineffective, I would have just put Seroquel behind me and gone on with my life. My doctor's attitude, the rampant corruption in the drug industry, especially relating to the Zyprexa/diabetes cover-up, leaves me with the attitude "Seroquel almost got me, I'm going to get Seroquel, AstraZeneca and the American Psychiatric Association by spreading the word about how dangerous and ineffective Seroquel is.
kirsty

Cremorne, Australia

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#14
Aug 17, 2007
 
AMM wrote:
As the medications were reduced, the anger became more managable. When another patient made a nasty comment about how I was drinking juice shortly after dosage reduction began, I threw the juice at him. A few days later the same patient commented "you have to finish 8th grade to use the remote", I responded with "I finished college before you were out of diapers". Also notice that the specific comments were remembered at least long enough to report them to staff. As Thorazine and Haldol were eliminated, so too was any further agressive outbursts. The pattern seems to be clear, the medication does nothing to reduce the real level of symtoms, rather to sedate so that symptoms appear to be reduced. The doctors always responded to agressive behavior with increased medication, even when the level of sedation was extreme, appearantly without considering that the medications may actually be making the agression worse.
The outcome of the hospitalization would have been completely different if I hadn't resumed taking Seroquel. I would have interacted with staff and other patients, attended groups, and would have been discharged in a fraction of the time. Although this experience can't be considered representative of what effects the medications would have on most or all other patients in other situations, it leaves me seriously considering if there is such a thing as "theraputic antipsychotic effect" from Seroquel and other antipsychotic medications.
I could have gone off Seroquel due to the side effects, and if I hadn't found extensive evidence that Seroquel is dangerous and ineffective, I would have just put Seroquel behind me and gone on with my life. My doctor's attitude, the rampant corruption in the drug industry, especially relating to the Zyprexa/diabetes cover-up, leaves me with the attitude "Seroquel almost got me, I'm going to get Seroquel, AstraZeneca and the American Psychiatric Association by spreading the word about how dangerous and ineffective Seroquel is.
i strongly agree with u seroquel is dangerous. seroquel is a isolating and numbing anti-psycotic drug that does not help long term. i am still trying to get bak to the place i was b4 i started them good luck to u amm
chipper

United States

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#15
Aug 17, 2007
 
MOST PSYCHIATRISTS HAVE PARTICULAR MEDICATIONS THEY FEEL COMFORTABLE PRESRIBING TO PATIENTS DEPENDING ON THERE DIAGNOSIS OF THE INDIVIDUAL.UNFORTUNITILY, PSYCHIATRY IS LESS OF AN EXACT SCIENCE THAN WE WOULD LIKE TO THINK.OFTEN THEY DO ATTEMPT TO TREAT VARIOUS DISORDERS ACCORDING TO THERE EXPERIENCE IN PRACTICE, DIAGNOSES W/ REGARD TO DSM IV, AND HISTORY OF THE CLIENTS PREVIOUS PROGRESS W/ OTHER ANTIPSYCHOTICS OR MOOD STABILIZERS.THESE MEDICATIONS ARE OF A WIDE VARIETY AND OFTEN THE OLDER TYPICAL ANTIPSYCHOTICS HAVE VERY HARSH SIDE EFFECTS,SEROQUEL IS ONE IN PARTICULAR.I WOULD SUGGEST REQUESTING OR DEMANDING,IF NEED BE, A SECOND OPINION.THERE ARE MANY NEW ATYPICAL ANTIPSYCHOTIC MEDICATIONS W/ VERY LITTLE SIDE EFFECTS NOW ON THE MARKET.AGAIN, TREATMENT W/ THESE MEDICATIONS ARE VERY INDIVIDUALISED.WHAT HELPS ONE MY BE DETREMENTAL TO THE OTHER.I REALIZE THIS IS NO ANSWER,HOWEVER,I HOPE IT WILL HELP SOMEONE IN SOMEWAY.
snoopy

Bridgewater, NJ

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#16
Aug 22, 2007
 
i was prescribed a very low dose of seroquel and find that it's helped me focus better. i know that the general vibe in this forum is that seroquel is bad...but i kind of like it. My choice is either to stay on this, try a more formal mood stabilizer like depakote or struggle through life.

to me, the seroquel seems like the best choice because i can take it as needed.(though I'm beginning to think that might be daily.)

thoughts?
snoopy

Bridgewater, NJ

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#17
Aug 22, 2007
 
ps...i don't live in abington!
AMM

Des Plaines, IL

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#18
Aug 22, 2007
 
It's almost impossible to take Seroquel as needed, because you won't be able to sleep without it. The ability to focus better is a result of impaired brain function, Seroquel blocks emotions and slows processing, hence blocking out multiple thoughts. The result after years of Seroquel use is an inability to think creatively and learn new things. Seroquel is highly addictive, after a few doses most people would never want to take more, however once dependent the anxiety and insomnia of withdrawl make it extremely difficult to quit. In the long run, dealing with side effects like weight gain, excessive sleeping and constant fatigue will make it even more difficult to struggle through life.
snoopy

Bridgewater, NJ

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#19
Aug 23, 2007
 
okay, thanks...i'll continue to think about this. just so you know though, I only take half a pill which is 12.5 mg. and i don't take it every day. my therapist suggested that i experiment taking it every day for a week to see if i noticed some stability in my mood/ability to focus. and i have...which is why i'd like this to work. but, obviously still need to think about it.

thanks again
Stimulant

Ireland

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#20
Aug 27, 2007
 
Hey guys,
The point being missed here is that any anti-depressant, SSRI or whatever, is a highly addictive mind-altering drug pushed by the psychiatric and pharmaceutical industry.
Years ago, they used LSD and speed as their drugs of choice on prescription. Believe me, many of the patients they dealt with felt better; for a while. The effects were so bad long term that even the government stepped in and banned LSD and speed. Thus it became outlawed.
Anti-depressants are actually classed in the same category as speed and LSD... Oh you didn't know!!!???? Well they are hardly going to tell you. They are in the same category and are simpy renamed and a few different forms of chemicals put into it. Of course people will feel better taking them now, but longterm, they are highly DANGEROUS.
Challenge your MD and psychiatrist. They only prescribe this shit because they are taught to. And what they are taught on the mind is DEEPLY flawed

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