Accutane Side Effects Exposed: Side Effects of the Miracle Drug...

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If you suffer from severe case of acne that has failed to respond to conventional treatments such as antibiotics, then your dermatologist may recommend the use of the popular Accutane or Isotretinoin. Full Story
silverado

Seattle, WA

#1689 Jun 7, 2008
Grover wrote:
oh and i have a friend who has followed the raw food diet for i don't know how long (cause i only met him in January) anyways, he has really bad acne, but is like you and will never take accutane, he has accepted it and it doesn't phase him. He's a really positive guy.
I understand womens indirect language/code perfectly.

I am positive and charismatic.

I prefer to bust womens chops, tease and have fun rather than suck up, kiss but, buy attention with things, seek approval and other crap like that.
And I have had every possible test a woman could throw at me, which is why I look forward to the first clash in a relationship.
Grover

Kyle, TX

#1691 Jun 8, 2008
silverado wrote:
<quoted text>
I understand womens indirect language/code perfectly.
I am positive and charismatic.
I prefer to bust womens chops, tease and have fun rather than suck up, kiss but, buy attention with things, seek approval and other crap like that.
And I have had every possible test a woman could throw at me, which is why I look forward to the first clash in a relationship.
That was random.
Hels

Gateshead, UK

#1692 Jun 8, 2008
Just for added info, I've been on 20mg a day for 10 days now and the 'dryness' really started for me around day 7. My skin has got very dry, prickly & sensitive to the sun so using a factor is quite important now while Im outside. My scalp is also prickly and my hair has got very dry.. its not nice but its not unbearable!
The lips are the worst irritation for me though... Im using Blistex but like someone else on here said, they feel dry from the INside out so nothing relieves it that much. If anyone has any tips on the whole dry lips thing then do comment!
Anyhow, so far so good (ish) and well worth it if it works.
Good luck all ...
Grover

Kyle, TX

#1694 Jun 8, 2008
Hels wrote:
Just for added info, I've been on 20mg a day for 10 days now and the 'dryness' really started for me around day 7. My skin has got very dry, prickly & sensitive to the sun so using a factor is quite important now while Im outside. My scalp is also prickly and my hair has got very dry.. its not nice but its not unbearable!
The lips are the worst irritation for me though... Im using Blistex but like someone else on here said, they feel dry from the INside out so nothing relieves it that much. If anyone has any tips on the whole dry lips thing then do comment!
Anyhow, so far so good (ish) and well worth it if it works.

Good luck all ...
Aquaphor for your lips and nose(if needed), its at any pharmacy and grocery store.

Also, i wash my face with cetaphil (also everywhere) and then follow it with cetaphil moisturizer which i rub into my lips as well, i'm on 60 a day but i do alot to keep my dryness down.

Inshower lotions are awesome

Humidifiers help

Have lotion with you all the time and try not and scratch with your nails cause you can cut yourself pretty easy.

ALSO if you scalp is really bothering you ask your doctor about "dermasmooth" you wear it at night and it hydrates your scalp..and hair and it really really helps, i have psoriasis and the dryness made it worse and this helps alot!!!!

Let me know if you have anymore questions!
silverado

Seattle, WA

#1695 Jun 8, 2008
Grover wrote:
<quoted text>
Aquaphor for your lips and nose(if needed), its at any pharmacy and grocery store.
Also, i wash my face with cetaphil (also everywhere) and then follow it with cetaphil moisturizer which i rub into my lips as well, i'm on 60 a day but i do alot to keep my dryness down.
Inshower lotions are awesome
Humidifiers help
Have lotion with you all the time and try not and scratch with your nails cause you can cut yourself pretty easy.
ALSO if you scalp is really bothering you ask your doctor about "dermasmooth" you wear it at night and it hydrates your scalp..and hair and it really really helps, i have psoriasis and the dryness made it worse and this helps alot!!!!
Let me know if you have anymore questions!
As a note. Psoriasis is a fungus.

The more you dry skin permanently with accutane the worse your psoriasis will get.

It thrives in dry skin because the protective acidic oil mantel and any disruption to it is what controls fungus as well as bacterial infection entry such as staph

It will spread because you will have microcracks all over your body and no lotion contains the correct bio makeup/p.h/ fungal, bacterial enzyme inhibitors as your skin oils do to control its overgrowth.

I only had facial acne when I started accutane. By month 8 or so I exploded with over 200 infections body-wide some the size of quarter.

Subsequent dry lung which led to fungal lung pneumonia. Both of these sent me to the emergency room at 3 am and I nearly lost my life because my immune system was obliterated.

One of the side effects of accutane is destruction of neutrophils.

Neutrophils is one of the largest parts of your immune fighting cells and neccessary to keep pathogens of all kinds under control. This is why my immune system collapsed.

All your doing is shutting off your protective sebum oils that keep your skin YOUNG, SMOOTH, SUPPLE AND WRINKLE FREE and destruction of the protective acidic oil mantel and replacing that with a lifetime use of chemical moisturizer this and chemical that.

I now have calcified granuloma, of the right lung, residual thymus, Spine damage, right shoulder joint damage, massive scarring all over.

This internal damage is evident on MRI and was not evident on MRI one month prior to accutane for a routine physical.

You are making a huge mistake and you like others that fail to listen and plow forward thinking this just some kind of inconveinient dryness will learn like me, tom, accupoisened and many, many others that have found out the hard way.

Your no expert to be giving advice here playing down the side effects as just some kind inconvienient dryness that is resolved with a smorgasborg of lotions and chemicals.

Get used to dry skin for the rest of your life and more.

to katreen

San Diego, CA

#1696 Jun 8, 2008
joint decomposition. serious. knees. inability to walk. pain. increased acne.

government experimentation at cost of patient looking for cure for her one and only ailment-- imperfect skin.
Grover

Austin, TX

#1699 Jun 10, 2008
silverado wrote:
<quoted text>
As a note. Psoriasis is a fungus.
The more you dry skin permanently with accutane the worse your psoriasis will get.
It thrives in dry skin because the protective acidic oil mantel and any disruption to it is what controls fungus as well as bacterial infection entry such as staph
It will spread because you will have microcracks all over your body and no lotion contains the correct bio makeup/p.h/ fungal, bacterial enzyme inhibitors as your skin oils do to control its overgrowth.
I only had facial acne when I started accutane. By month 8 or so I exploded with over 200 infections body-wide some the size of quarter.
Subsequent dry lung which led to fungal lung pneumonia. Both of these sent me to the emergency room at 3 am and I nearly lost my life because my immune system was obliterated.
One of the side effects of accutane is destruction of neutrophils.
Neutrophils is one of the largest parts of your immune fighting cells and neccessary to keep pathogens of all kinds under control. This is why my immune system collapsed.
All your doing is shutting off your protective sebum oils that keep your skin YOUNG, SMOOTH, SUPPLE AND WRINKLE FREE and destruction of the protective acidic oil mantel and replacing that with a lifetime use of chemical moisturizer this and chemical that.
I now have calcified granuloma, of the right lung, residual thymus, Spine damage, right shoulder joint damage, massive scarring all over.
This internal damage is evident on MRI and was not evident on MRI one month prior to accutane for a routine physical.
You are making a huge mistake and you like others that fail to listen and plow forward thinking this just some kind of inconveinient dryness will learn like me, tom, accupoisened and many, many others that have found out the hard way.
Your no expert to be giving advice here playing down the side effects as just some kind inconvienient dryness that is resolved with a smorgasborg of lotions and chemicals.
Get used to dry skin for the rest of your life and more.
I;m sorry you had to go through that?
How old were you?
silverado

Seattle, WA

#1701 Jun 10, 2008
Grover wrote:
<quoted text>
I;m sorry you had to go through that?
How old were you?
mid 30s
Grover

Austin, TX

#1702 Jun 10, 2008
I CAN"T BELIEVE YOU SPELLED "SMORGASBORG" right, sorry that just hit me. that's awesome.
Anyway, ya i've have psoriasis since childhood, and the stress of college really made it worse. I'm not all that dry either, but the tx humidity helps with that.
So did eating raw really help with your face?
isn't with that raw food nothing can be cooked over about 150 degrees b/c any higher would damage all the nutrients within the food.
for meat do you eat sushi grade tuna?
Grover

Austin, TX

#1703 Jun 10, 2008
silverado wrote:
<quoted text>
mid 30s
I've noticed that the side effects seem to be worse as a person gets older. Every one my age has had no problems at all. However, anyone i talk to that is mid 20's and up seems to have extremely horrific side effects. That's just an observation though.
silverado

Seattle, WA

#1704 Jun 10, 2008
Grover wrote:
<quoted text>
I've noticed that the side effects seem to be worse as a person gets older. Every one my age has had no problems at all. However, anyone i talk to that is mid 20's and up seems to have extremely horrific side effects. That's just an observation though.
If you look on this board for a thread called "accutane and diabetes" there are 15, 16, 17 year olds that now have permanent diabetes from accutane related organ damage. Same with chronic hair loss years post accutane.

Personally I lost no hair at all and have a full head of hair. Yet there are young people here complaining of chronic hair loss.

So it is dependent on your bio-make/dietary intake/habits what side effects you will get.

Many other conditions are non-age specific.
From my observations the suicide rate is higher within the younger age group.

The accutane "I-pledge" extended warning list is not age specific.

Granted all of our bodies have a different bio- make up of metabolism, fats, protiens, cholesterols etc, etc. as well as many other things that varies and that is what determines which side effect you will get.

Other things such as joint/spine damage are pretty much common to all because accutane shuts off hylauronic acid,(the body's water retention molecule in between collagen molecules), as well as has been shown to destroy cartilage.

Because accutane interfers with bone mineral metabolism I think women especially will develope osteoporosis earlier in life after accutane useage.
Grover

Kyle, TX

#1706 Jun 10, 2008
silverado wrote:
<quoted text>
If you look on this board for a thread called "accutane and diabetes" there are 15, 16, 17 year olds that now have permanent diabetes from accutane related organ damage. Same with chronic hair loss years post accutane.
Personally I lost no hair at all and have a full head of hair. Yet there are young people here complaining of chronic hair loss.
So it is dependent on your bio-make/dietary intake/habits what side effects you will get.
Many other conditions are non-age specific.
From my observations the suicide rate is higher within the younger age group.
The accutane "I-pledge" extended warning list is not age specific.
Granted all of our bodies have a different bio- make up of metabolism, fats, protiens, cholesterols etc, etc. as well as many other things that varies and that is what determines which side effect you will get.
Other things such as joint/spine damage are pretty much common to all because accutane shuts off hylauronic acid,(the body's water retention molecule in between collagen molecules), as well as has been shown to destroy cartilage.
Because accutane interfers with bone mineral metabolism I think women especially will develope osteoporosis earlier in life after accutane useage.
Ya, my bone density is good, the body composition "tech" is i guess what you would call her, said that i had the highest bone density she had ever seen. That is due to my exercise.

The one crazy side effect i have had is ingrown nails, SERIOUSLY ingrown nails, so painful, and they go from nothing to surgical over night. After i had two the lowered my dose to 40 mg a day, but they increased it last week, and.........i think I'm getting another.

I can definitely understand the suicide rate being higher for the younger. I got pretty depressed during finals, due to high stress, home sickness, weight gain, and lack of exercise.

My sister had zero side effects besides dryness, she was really lucky.

When you had your serious side effects did you stop or lower your treatment?
silverado

Seattle, WA

#1708 Jun 10, 2008
Grover wrote:
<quoted text>
Ya, my bone density is good, the body composition "tech" is i guess what you would call her, said that i had the highest bone density she had ever seen. That is due to my exercise.
The one crazy side effect i have had is ingrown nails, SERIOUSLY ingrown nails, so painful, and they go from nothing to surgical over night. After i had two the lowered my dose to 40 mg a day, but they increased it last week, and.........i think I'm getting another.
I can definitely understand the suicide rate being higher for the younger. I got pretty depressed during finals, due to high stress, home sickness, weight gain, and lack of exercise.
My sister had zero side effects besides dryness, she was really lucky.
When you had your serious side effects did you stop or lower your treatment?
At month 8 or so (pneumonia/massive body-wide breakout/infections), the Emergency room Doc said "This is NOT normal". The Dermatologist said, "Its normal, "Just ride it out", "This happens to everyone".????

I didnt know who to believe and not enough about accutane at the time because, "I pledge" (extended warnings) werent available and had no computer at the time for research.

I didnt want to interfer with the treatment, thought it was unrelated and due to the pneumonia so went with the Derms advice and continued.

I thought the breakout period would eventually stop, but it didnt until I finally ceased using it. It was all due to the accutane.

Approximately 200 scars. 57 on my right arm alone . I never had "acne" or any other skin problem on my arms prior to accutane nor my legs/calves.
My back looks like someone shot me with a shot gun a couple of times.
Grover

Kyle, TX

#1709 Jun 10, 2008
That's insane!!!!!

I would've sued.
Gosh, i can see why you are so against it.
I'm so sorry, that sounds so horrible, and i thought an ingrown was bad,(which i removed the new one).

I can't believe your dermatologist just blew that off! That makes me get all flustered and pissed.

You shouldn't be self conscience about your scars though...they are way hotter than acne.... and i'm not joking, i once knew a burn victim who had half his face and body scarred and ...ya, that just made him hotter. I don't know if that helps you at all, but that's a girls perspective for ya.

However, that doesn't justify what happened to you or make it any better.
Hels

Gateshead, UK

#1710 Jun 11, 2008
Grover thanks very much for your advice re combatting the dryness... its really getting me down! Im going to get those products you've recommended. Its now more my skin (face) thats causing me problems as I cant even wear makeup anymore.. it just flakes off!

Anyway thanks again!
Grover

Kyle, TX

#1711 Jun 11, 2008
Hels wrote:
Grover thanks very much for your advice re combatting the dryness... its really getting me down! Im going to get those products you've recommended. Its now more my skin (face) thats causing me problems as I cant even wear makeup anymore.. it just flakes off!
Anyway thanks again!
Np prob, anything to help

get an more hydrating make up, neutrogena, healthy skin enhancer, its a pump and its very hydrating and light, and it's great in the summer.

Or just moisturize your face before applying makeup and you should be fine, pay attention to around the eyes and mouth the most.
Monica

Portland, OR

#1713 Jun 11, 2008
I just went in to get my 3rd month of accutane pills and I told my dermatoligist about my side effects.I've been soooo tired and getting a little down and a lot of joint pain.So she took me off the pill for 1 week so see if I feel better and then she will lower my dose.So if your having side effects it's defentily good to take a little break and I already feel so much better.So we'll see if I get back on it lol.
NCC

Trinidad, CO

#1716 Jun 13, 2008
Accutane: castration from the inside
Accutane reduces the levels of testosterone receptors in the body. This article applies this to the skin, which must account for a lot of testosterone reception as the skin is a large area of the human body, but what's to say that this doesn't occur for all testosterone receptors in the body?
With a blood test, Accutane patients will test normal on testosterone level and DHT. However, the message is going around, but no-one is there to receive it because the receptors for the testosterone in the body are decreased 2.6 fold by Accutane, as proved by the study below. And this is just after 3 months. Rather than the removal of your balls from the outside of your body, your ability to receive the testosterone is removed from the inside of your body.
This study came out way back in 1995, but do they bother to share this information with acne patients?
http://jcem.endojournals.org/cgi/content/abst...
Effect of oral isotretinoin treatment on skin androgen receptor levels in male acneic patients
P Boudou, H Soliman, M Chivot, JM Villette, P Vexiau, A Belanger and J Fiet
Department of Hormonal Biology, St. Louis University Hospital, Paris, France.
'Androgen receptor status was investigated in back skin biopsies obtained in acne areas before and after 3 months of isotretinoin treatment. The treatment did not modify the binding affinity constant of skin androgen receptor (0.44 vs. 0.32 nmol/L), but it did induce a 2.6-fold decrease in its binding capacity constant (62 vs. 24 fmol/mg cytosolic protein), as assessed by Scatchard plot and confirmed immunologically by Western blot analysis. These data clearly showed that skin androgen receptor was sensitive to oral isotretinoin administration in acneic patients. The decrease in skin androgen receptor levels (this study) and the recently reported suppression of skin 5 alpha-dihydrotestosterone production by isotretinoin treatment appeared consistent with the involvement of androgen receptor and 5 alpha-dihydrotestosterone in the pathogenesis of acne. Indeed, sebum production is under androgen control, and an abnormal response of the pilosebaceous unit to androgens appears to be implicated in the pathogenesis of acne. These observations were consistent with the absence of sebum in complete androgen-insensitive patients and normal sebum production in male pseudohermaphrodites.'
NCC

Trinidad, CO

#1717 Jun 13, 2008
Most of you are extremely naïve and have absolutely no idea what you’re dealing with, let me give you a quick crash course on Accutane’s history and pharmacology. Not a lot of people know this but Accutane is not technically an acne medication, it was originally developed to be a chemotherapy drug back in the 1970’s and is still used as chemotherapy today for leukemia, pancreatic cancer, brain tumors, and other types of cancers. It has powerful systemic cell division reducing effects throughout the entire body, and acne reducing skin dryness happens to be one of its side effects. Cancer chemotherapy drugs by their very nature are the most powerful and toxic pharmaceuticals used in conventional medicine. During clinical trials in the late 1970’s, researchers discovered that some of their cancer patients had their acne cleared up during their chemotherapy. Hoffman-La Roche couldn’t make enough money with Accutane as a chemotherapy drug so they decided to expand it with clever marketing and fraudulent clinical trials. This is when all logic and common sense got thrown out the window and Accutane slowly became known as a popular treatment for acne. Roche accomplished this by paying off several different doctors (Dr. William Cunliffe, Dr. Douglas Jacobs, Dr. Susan Jick) to promote Accutane as a safe and effective drug for acne. Near the beginning of an Accutane documentary that was broadcast in Switzerland last year, United States attorney Mike Papantonio was quoted saying,

“The interesting thing about this drug it’s that it was never intended for something like clearing up pimples. This was a drug that was intended for chemotherapy. Roche could not make enough money with it just with chemotherapy, so they said: Let’s expand it. Let’s sell it to more people. And they ended up selling it to people with acne.”

http://www.accutaneaction.com/swiss_tv/061114...

I've got a question for everyone and all the dermatologists out there who don’t believe that Accutane affects brain function, and therefore had nothing to do with all of the reported psychiatric injuries, suicides, and murders. If Accutane supposedly only affects the skin, then why do oncologists use it for pancreatic cancer, leukemia, brain tumors and other certain types of cancers?
NCC

Trinidad, CO

#1718 Jun 13, 2008
http://www.seniorfitness.com/Show_Disease_and...

“Accutane: Based on the need to inhibit pancreatic cancer cell division at different stages of its growth and induce apoptosis (programmed cell death) of cancer cells, multiple therapeutic modalities are often recommended. One successful treatment modality is to combine the differentiating-inducing drug Accutane (13-cis-retinoic acid) with other chemotherapy drugs, such as 5-FU. Both Accutane and 5-FU are toxic drugs that must be carefully administered by a medical oncologist. A combination of 13-cis-retinoic acid (Accutane) and interferon-alpha was tested in a Phase II trial of 22 patients with pancreatic cancer. One patient experienced partial remission and 14 patients demonstrated stable disease for about 5 months (Brembeck et al. 1998).”

Joseph Mercola, D.O. states on his website “Chemotherapy, which has been one of the principal treatment methods for the past 50 years, works by killing all cells - throughout your body - that multiply and divide rapidly. This would include cancer cells, but also other rapidly multiplying and dividing cells, such as: Bone marrow (which produces blood), Digestive system, Reproductive system, Hair follicles.” http://www.mercola.com/

Throughout the past 25 years that Accutane has been on the market, Hoffman-La Roche has used the lame excuse in the Physician’s Desk Reference that the exact mechanism of action of Accutane is unknown. They don’t mention that Accutane is a systemic chemotherapy agent that reduces cellular proliferation of the sebaceous glands in the skin all over the body (which is why it’s so effective against acne), and also does the same thing to the cells lining the digestive tract and mucous membranes (causing a lot of dryness). To corroborate my previous statement, take a look at what scientist James Crandall says in a study that can be found on PubMed. He is stating point blank this is how Accutane works and this is what’s causing the side effects.

"Retinoic acid (active form of Accutane) induces differentiation and reduces proliferation of stem and progenitor cells. It works on acne by inducing similar events in basal sebocytes. These same actions also lead to 13-cis-retinoic's (Accutane’s) side effects, and these are directed towards proliferating cells in the adult such as in the skin, gut and bone."

"A wide ranging effect of retinoic acid is to inhibit proliferation in dividing cells, and this accounts for its frequent consideration as an anti-cancer agent."

http://www.pubmedcentral.nih.gov/articlerende...

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