Epigenetic biomarker for early-onset ...

Epigenetic biomarker for early-onset colorectal cancer detection

Posted in the Colon Cancer Forum


Madison, WI

#1 Sep 25, 2012
US patent application published on Sept. 20, 2012 – Described the application of LINE-1 methylation level as a marker for the diagnosis of early-onset colorectal cancer (CRC). LINE-1 methylation levels in tumors derived from two independent cohorts of early-onset CRC were significantly lower compared with older-onset CRCs and Lynch syndrome tumors. LINE-1 hypomethylation levels were similar in older-onset sporadic MSI tumors, Lynch syndrome CRCs and sporadic MSS tumors.
Details: http://www.sciclips.com/sciclips/biomarker-ne... [Patent%20News]

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