New lung cancer treatment study

New lung cancer treatment study

There are 37 comments on the New York Daily News story from May 14, 2006, titled New lung cancer treatment study. In it, New York Daily News reports that:

Queens Cancer Center Associate Director Gina Villani and Registered Nurse Linda Bulone will be part of new study.

Join the discussion below, or Read more at New York Daily News.

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gdpawel

Philadelphia, PA

#1 May 15, 2006
Several new "targeted" drugs, like Tarceva and Avastin, have been introduced during the last few years. Most of them have been developed for use in solid tumors but some have also emerged for hematological maligancies. These new "targeted" drugs mostly need to be combined with active chemotherapy to provide any benefit and the need for predictive tests to individualize therapy selection has increased.

Unfortunately, the introduction of these new drugs has not been accompanied by specific predictive tests allowing for a rational and economical use of the drugs. Given the technical and conceptual advantages of cell cuture assays together with their performance and the modest efficacy of therapy prediction based on analysis of genome expression, there is reason for a renewal in the interest for cell culture assays for optimized use of medical treatment of malignant disease.

There was a recent study using an angiogenesis assay, describing correlations between cell culture assay results (cell death in response to Iressa exposure) and survival of patients with non-small cell lung cancer who had received extensive prior chemotherapy. These correlations were based on the actual assay results which had been reported, in real time, prospectively to the doctors who had ordered the assay laboratory tests. There were striking correlations between test results and patient survival.

By inhibiting anti-apoptosis with Iressa, or even Tarceva and Avastin, the cells can undergo apoptosis and die. And it is detected at the whole cell level in the cell culture assays and reported out -- prospectively -- that this correlates strikingly with patient survival. Not only is it a very important predictive test, but it is a unique tool for identifying newer, better drugs, testing drug combinations, and serving as a "gold standard" to develop new DNA, RNA, and protein-based tests of drug activity.
Dan Eichost

White House, TN

#2 May 15, 2006
I have stage four lung cancer, Pancoast Tumor. When I was diagnosed, in Jan '01, I was told I had 6 months to live. I had 17 treatments of radiation and 10 doses of chemo, 6 weeks apart. I am currently on Iressa. It's been over 5 years and I'm still here, my oncologist can't explain it, he says I'm his miricle patient.
gdpawel

Philadelphia, PA

#3 May 15, 2006
Iressa has been shown to benefit those that are benefitting from it. It may have been a hastely-made move to pre-maturely withdraw the drug from clinical trials last year. The drug is approved in Europe, Canada, Japan, and had been approved in the U.S., but the FDA revoked it, telling AstraZeneca (the owner/developer of Iressa) that they need a test to pre-identify patients who would most benefit from it. If the drug IS working for some people, then obviously there are others out there who would also benefit. This is, yet again, a great argument for Cell Culture Assay Tests of an individual's tumor before treatment.
Chris

Hangzhou, China

#4 Aug 4, 2006
Dan Eichost wrote:
I have stage four lung cancer, Pancoast Tumor. When I was diagnosed, in Jan '01, I was told I had 6 months to live. I had 17 treatments of radiation and 10 doses of chemo, 6 weeks apart. I am currently on Iressa. It's been over 5 years and I'm still here, my oncologist can't explain it, he says I'm his miricle patient.
-Actually you could use some alternitive therapy to make your life even longer with much better quality. Reply to: [email protected]
Dan Eichost

United States

#5 Oct 27, 2006
Chris wrote:
<quoted text>
-Actually you could use some alternitive therapy to make your life even longer with much better quality. R ly to: [email protected]
What kind of alternative therapy do you mean?
Penny

AOL

#6 Oct 28, 2006
I was diagnosed with stage 4 NSC lung cancer in March of 03 after 8 rounds of carbo& Taxel with shrinkage I'm now on Avastin and Tarceca with stable disease for the last year, yes like you I'm considered a walking miracle
Diane

Orlando, FL

#7 Nov 26, 2006
Is anyone who is on Avastin and Tarceva experiencing fatigue? I have just completed 7 weeks of therapy, and am experiencing fatigue that I never experienced when having Chemotherapy. I had 8 sessions of Gemzar and parplatin over 24 weeks and never experienced fatigue or nausea, however I am finding that with Tarceva and Avastin, I can not seem to 'not be tired'! I have stage 3b adenocarcinoma lung cancer.
K_M_Varghese

Singapore, Singapore

#8 Dec 4, 2006
What is Cancer Remission?
Marie Hakala

Mankato, MN

#9 Jan 21, 2007
My husband who has congestive heart failure and diabetes was dx with stage 3b non small cell lung cancer in Feb of 2006. Due to his overall condition he received chemo at lower amount but had 12 chemo treatments one week apart and had 30 radiation treatments. He did better than most and we feel the fact that he was on TAHITIAN NONI Juice from Tahitian Noni International as well as tumeric and a good multiple vitamin and folic acid has got him to almost one year since dx. He has less side affects than many. Although he was really weak at the end of the treatment. But he is still with us and doing quite well right now.
Phyllis

Little Rock, AR

#10 Jan 22, 2007
I was diagnosed jan 01 with stage iv nsc lc, surgery was unsuccessful and was given 6m to 3y. I have had several rounds of chemo, and iressa for 2yr 9m, and finally tarcevia 100mg since Apr 05. My lungs were clear but now two spots have returned. My biggest problem is the loss of much of my eyesight. The cornea's won't stay healed. I have developed severe dry eyes. Is anyone having trouble with their vision?
K_M_Varghese

Singapore, Singapore

#11 Jan 22, 2007
Hi Doctor,
What are the common drugs taken by a HIV patient and does this Drug have any after effect?
Thanks in advance
canada

Saint John, Canada

#12 Feb 6, 2007
I have just been approved for tarcevia
After reading this I wonder if I should try Tarcevia. Stage 3 lung cancer.
carol

Singapore, Singapore

#14 Feb 23, 2007
my father has stage iv nsc lung cancer. 2 sides lungs, medium lympha nodes and lympha nodes near the kidney below. he is on morphine now cause he has a lot of pain. spitting rusty phlegm and can breathe well while lying down. any advice?
Scott French

United States

#15 Feb 24, 2007
My mother has stage 4 lung cancer spread to her stomach and overies, any help, suggestions, alternative therapies ETC please e-mail me @ [email protected] Thank you
carol

Singapore, Singapore

#16 Feb 24, 2007
can anyone give me advice on how we should take care of my father. He always feel that he can't breathe. He is on supplements and can eat quite well, bit by bit. Now his pain is under control by morphine. His problem now is alot of phlegm inside and spit out blood about 3 times a day and cant breathe well. He is 71 yrs old but still very active 3 months ago. He had chemo and radiation from june 06 to Aug 06 and was well after that for about 3 months. He is so weak now and can only sit and sleep. Can anyone tell me if there's anyway to improve his condition? Help help help
carol

Singapore, Singapore

#17 Feb 24, 2007
Scott French wrote:
My mother has stage 4 lung cancer spread to her stomach and overies, any help, suggestions, alternative therapies ETC please e-mail me @ [email protected] Thank you
I will be checking with my dad's medical oncologist if the targetted drugs: tarceva, iressa or avastin will help my father. Maybe u may check with your oncologist too. I have read many people who had been treated with these had gone into remission.
carol

Singapore, Singapore

#18 Feb 24, 2007
Diane wrote:
Is anyone who is on Avastin and Tarceva experiencing fatigue? I have just completed 7 weeks of therapy, and am experiencing fatigue that I never experienced when having Chemotherapy. I had 8 sessions of Gemzar and parplatin over 24 weeks and never experienced fatigue or nausea, however I am finding that with Tarceva and Avastin, I can not seem to 'not be tired'! I have stage 3b adenocarcinoma lung cancer.
have your condition improved?'
carol

Singapore, Singapore

#19 Feb 24, 2007
Penny wrote:
I was diagnosed with stage 4 NSC lung cancer in March of 03 after 8 rounds of carbo& Taxel with shrinkage I'm now on Avastin and Tarceca with stable disease for the last year, yes like you I'm considered a walking miracle
Hi Penny,i felt encouraged and hopeful after reading about your condition. I m so worried about my father, stage 4 nsc, he is very weak now and is spitting out blood everyday and has difficulty in breathing, do u have any advice for me whether my dad will be cured.
lz_boston

Somerville, MA

#20 Apr 3, 2007
my uncle has stage 4 lung cancer spread to rib and liver. Any suggestion, alternative medicine ETC would be highly appreciated. Please email: [email protected]
Pam

Naperville, IL

#21 Apr 10, 2007
Diane wrote:
Is anyone who is on Avastin and Tarceva experiencing fatigue? I have just completed 7 weeks of therapy, and am experiencing fatigue that I never experienced when having Chemotherapy. I had 8 sessions of Gemzar and parplatin over 24 weeks and never experienced fatigue or nausea, however I am finding that with Tarceva and Avastin, I can not seem to 'not be tired'! I have stage 3b adenocarcinoma lung cancer.
My dad has Stage IV NSCLC and has been taking tarceva for 2.5 weeks. On the 14th day he became extremely lethargic and slept most of the next 48 hours (which brings us to today). I am concerned but the doctor says fatigue is very common. You are in my prayers, keep my dad in yours.

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