Cancer Drug "Holiday" May Extend Pati...

Cancer Drug "Holiday" May Extend Patient Survival

There are 3 comments on the MediLexicon story from Jan 10, 2013, titled Cancer Drug "Holiday" May Extend Patient Survival. In it, MediLexicon reports that:

New research on mice shows that drug-resistant melanoma tumors shrink when treatment is interrupted, or given a "holiday", suggesting that altering the dose pattern of cancer drug treatment in this manner could be a simple way to extend survival in human patients with late-stage disease.

Join the discussion below, or Read more at MediLexicon.

Since: Dec 05

Reading, PA

#1 Jan 10, 2013
Even in previously failed therapies, results from phenotype analysis have seen numerous occasions in which a drug used earlier becomes effective again, once the tumor has been removed from the selective pressure of drug exposure. The tumor loses the capacity to resist.

Changes induced by subsequent treatment may bring the tumor back to a point where failed drugs are viable again. A number of laboratory oncologists have tested many small molecules and in the past studied the P-glycoprotein and GST inhibitors to reverse drug resistance.

Zelboraf (vemurafenib) exploits the fact that BRAF proteins in healthy cells pair up with other BRAF proteins to form a multiprotein complex, while the mutated BRAF protein acts as a lone compound. This solitary structure can be hundreds of times more effective in activating cell division than the normal paired BRAF complexes.

Zelboraf (vemurafenib) targets tumor cells by only inhibiting the stand alone mutant version, while allowing the twinned version in healthy cells to act unimpaired. Secondary pathways, like NRAS and CRAF, may step to the fore and overtake the effect of the BRAF inhibition.

Using MEK/ERK inhibitors (vemurafenib) and PI3K/mTOR inhibitors, these laboratory oncologists can explore the activities, synergies and possible clinical utilities of these novel compounds, alone and in combination in human tumor primary culture microclusters. Exploration of horizontal pathway targeting.
Gordon
#2 Sep 23, 2013
I have ordered 2 times from this website PILLSMEDSHOP. COM . I called yesterday the customer care and asked for a discount as i was about to order twice the regular amount.
Conner

UK

#3 Sep 23, 2013
I have ordered 2 times from this website PILLSMEDSHOP. COM . I called yesterday the customer care and asked for a discount as i was about to order twice the regular amount.

Tell me when this thread is updated:

Subscribe Now Add to my Tracker

Add your comments below

Characters left: 4000

Please note by submitting this form you acknowledge that you have read the Terms of Service and the comment you are posting is in compliance with such terms. Be polite. Inappropriate posts may be removed by the moderator. Send us your feedback.

Cancer Discussions

Title Updated Last By Comments
LANGHAM CANCER RESEARCH @DERBY uk (Jul '13) Sat Andrew John Langham 19
News Video: Jimmy Carter to undergo treatment for ca... Aug 20 Well Wishes 1
Langham Medical Science Research Derby U.K. Aug 19 Andrew John Langham 1
News Making strides against breast cancer Aug 17 Caroline 1
News Medical researchers say fetal tissue remains es... Aug 12 cpeter1313 7
News Save the Chickens and the Children Aug 2 Gof print 1
News Good sex after breast cancer treatment (Mar '13) Jul '15 kateB4u 7
More from around the web