Breast cancer drug Arimidex cleared f...

Breast cancer drug Arimidex cleared for use in post menopausal ...

There are 135 comments on the Earth Times story from Jul 12, 2006, titled Breast cancer drug Arimidex cleared for use in post menopausal .... In it, Earth Times reports that:

AstraZeneca's breast cancer drug Arimidex has been cleared by the European medicine regulators, for use as a new treatment option, in women suffering from post menopausal early breast cancer, who are currently ...

Join the discussion below, or Read more at Earth Times.

DENISE

Midland, MI

#21 Feb 19, 2007
Julie wrote:
I had twelve months of treatment for breast cancer
chemo and radiotherapy,in 2003. No further treatment as it was not hormone receptive. Whilst having chemotherapy I got what seemmed to be bone pain in the long bones this always eased towards the end of chemo cycles. Since finishing treatment I have started to get very bad pain in most of my joints I have been taking Nsaids which help but pains are getting worse. I am sure that chemo has caused this problem.
I remember writing about this in July 06. I hadnt heard much from what I wrote...now there ar soooo many people complaining about this stuf - its unreal! About 8+ months for me, long lasting pain still, and I had my last treatment about 11/05,arimidex 2+ months about kicked me all the way down, Im 45, had tamoxifen until recently, wanted to see difference getting off it...Ive been taking about 2 per week for some protection becasue im scared, I know its risky but I too feel like hell. Hot flashes stopped , had a 2/1/07 period (none since May 05), hands/feet general joints irritated usually always...now left inside knee feels like I pulled something for over 2 months (new symptom) Got a weird bump on my right foot that feels like its fractured if im on my feet all day. Being seeing a TOP Neurologist...thought I had a mini stroke after a fall 9/24/06 out of no-where, fell from 5 feet up off the edge of my deck out of no-where, bent over slightly to pluck heads of petunias..on the ground totally confused, then went on. So they did a brain Spect- they are seeing early onset alzheimers or dementia....Im a pretty intelligent person, my BFF has noticed a change.
DENISE

Midland, MI

#22 Feb 19, 2007
Connie wrote:
Hi Sharon,
I too, took Arimidex twice.
I suffered from numbness and pain in my feet and pins and needles in my legs, numbness in my fingertips. Also, terrible pain in my legs at night. The initial pain started after only 2 weeks on the Arimidex.
I was only off it for 14 days, both times before I went back on it. That was my onc's. suggestion. I realize that wasn't long enough.
Switched to Femara. Same numbness and other side effects as with Arimidex. Not horrible leg pains.
I am doing research for Breast Cancer Action as to whether other countries list the same side effects for the three AI's.
Would love to hear about your complete side effects.
You may want to check into the site which is www.bcaction.org
If you wish to contact me please feel free to do so.
[email protected]
I posted a few replies to other comments Feb 19, 2007... pretty much the same! wrote down your email and web site thank you!
DENISE

Midland, MI

#23 Feb 19, 2007
Helen wrote:
<quoted text>
My husband took neuROTEN it made him have bad night mares and I could not leave him alone.I called it stupid pills.Neck injury from car wreck, he went to chiropractor and is off it.crazy I know but he was not right.the drug messed with his mind after2 weeks enough was enough.
Thank god that didnt happen to me, but I know someone it did happen too. Ive had it since May, I may of had some depression, but it knocked the edge off with out altering my mind to a high. I tried Cymbalta for anxiety with all the physical issues I have, plus my mother 65 is now "counting her days". Best to your husband I hope he finds a suitable solution
DENISE

Midland, MI

#24 Feb 19, 2007
Joanne wrote:
Have any of you read the report on symptoms published by Breast Cancer Action? It can be found at http://www.bcaction.org/Pages/GetInformed/AIR...
The part about the high incidence of strokes really has me worried.
Now I'm glad to see this...there hasnt been one place that suggests iut could happen - I know it happened to me...freaked me out. I just dropped- don't remember a thing but I think it was bend, fall, blank mind no clue what or how it happened. I am going to look at that site! Thanks dfalsetti @charter.net
DENISE

Midland, MI

#25 Feb 19, 2007
Julie wrote:
I had twelve months of treatment for breast cancer
chemo and radiotherapy,in 2003. No further treatment as it was not hormone receptive. Whilst having chemotherapy I got what seemmed to be bone pain in the long bones this always eased towards the end of chemo cycles. Since finishing treatment I have started to get very bad pain in most of my joints I have been taking Nsaids which help but pains are getting worse. I am sure that chemo has caused this problem.
Whats Nsaids? I was hormone receptive, have had hands, feet, top feet, right thumb, lower back now hurts, shoulders, neck, had this since 1/06 over a year now - frankly I see no end in sight! Im considering going back to Karmanos before check date - they have got to know something, you'de think. My care was great there, two-time breast cancer survivor 98, 05 - scared out of my mind, hate the drugs.
Guylene Lefort

Montréal, Canada

#26 Feb 27, 2007
Vitamin D daily (500 units) and lots of exercice especially intense stretching.
Jo Ann

AOL

#27 Mar 12, 2007
I have been on Tamoxifen for about a year. I have horrible pain in my feet. The bone around my foot and bottoms of my heels hurt badly. It really hurts when I get up every morning to walk...I feel like I am getting older more quickly.
Ann

Schenectady, NY

#28 Mar 13, 2007
bette wrote:
I am wondering if anyone developed osteoarthritus after taking tamoxifen? I went through a course of chemo for breast cancer and went on Tamoxifen for 5 years. I am now taking Femara. I have had 2 total knee replacements in the past 2 years. I can't find a link between the treatments and arthritus,but wondered if there were some others who have experienced the same thing.
It's the Femara. It's producing major side effects of this type in many women. Talk to your doctor about it.
Marcia

Colton, CA

#29 Apr 10, 2007
Wow.. I have a great oncologist, yet I just learned SO much here!! Just finished 5 years on Arimidex (flashes, insomnia, achy joints, weepy weepy moods, lethargy)
Now I'm wondering what's next??? Anyone out there come off of it?? My onc said maybe my hair will get shiny... There are no studies about what to do past 5 years.... hmmmm. You have to wonder. OH - Acupuncture - definitely helped me with side effects.
Never found a shrink or anti-depressents that I was comfortable with...
best, marcia
the other helen

United States

#30 Apr 19, 2007
Samara wrote:
Hi...
My Mum has been taking Arimidex for about 8 months now and she has developed Kidney problems out of the blue..raised creatinine levels and potassium...and high blood pressure.
I wonder if anyone else has had similar problems.
Very worried :(
Yes, my dear mum also, after we're not sure how long on the Arimidex, doctor just NOTICED it this year (2007), but last year's blood test was bad also. 2003 was fine, started A then. Have you heard anything since you posted? I'm not finding anything here online on this subject, except that it looks like they haven't particularly MEASURED this side effect. I'm not sure they really know how or why kidneys "peter out". Why should they care? It's only old people who have to eat bland boring diets until they go on dialysis=dollars and THEN it gets interesting again? Sorry for the attitude - miserable oncologist appt today.
Shirley

Norcross, GA

#31 Apr 20, 2007
Marcia wrote:
Wow.. I have a great oncologist, yet I just learned SO much here!! Just finished 5 years on Arimidex (flashes, insomnia, achy joints, weepy weepy moods, lethargy)
Now I'm wondering what's next??? Anyone out there come off of it?? My onc said maybe my hair will get shiny... There are no studies about what to do past 5 years.... hmmmm. You have to wonder. OH - Acupuncture - definitely helped me with side effects.
Never found a shrink or anti-depressents that I was comfortable with...
best, marcia
Marcia, Have been on Arimidex for past 3 1/2 years. Side affects are similar to yours. Take Paxil for the Weepie's and walk to keep weight down. Managed to develop a problem with the thyroid after radiation (which probably caused the problem) so seem to be on track now. As for what's next for us when we finish our 5 years - well according to an oncologist from MDAnderson in TX there are two drugs being tested to deal with the 5 years and out protection. Here's hoping they get FDA approval in our lifetime.
Pat

Redmond, WA

#32 Apr 20, 2007
I am taking arimidex since last Aug.('06) after 5 years of tomoxafen. I was told arimidex is hard on the bones, and I should take boniva also. I had just had my 4th. scope,(egd) for two ulcers, that had appeared after 4 years of fosomax. Ulcers are healed, but I still have gastritis, so boniva is out. My 2nd opinion,(another oncologist) felt I needed the arimidex, but to not take boniva, but see an endrocrinologist. She did blood work and found all to be well except I was low in Vit. D. I now take Vit. D, as well as calcium, as I've taken for years, and will be monitored with bone density tests, q year or 6 mos. if needed till done with arimidex, hopefully 5 years or less. I have none of the symptoms the rest of you mention. I do have low back discomfort, and arthritis in my thumbs, but have had it 6years or more. MarPat_353msn.com
Lynn in Raleigh

Durham, NC

#33 Apr 22, 2007
Pat wrote:
I am taking arimidex since last Aug.('06) after 5 years of tomoxafen. I was told arimidex is hard on the bones, and I should take boniva also. I had just had my 4th. scope,(egd) for two ulcers, that had appeared after 4 years of fosomax. Ulcers are healed, but I still have gastritis, so boniva is out. My 2nd opinion,(another oncologist) felt I needed the arimidex, but to not take boniva, but see an endrocrinologist. She did blood work and found all to be well except I was low in Vit. D. I now take Vit. D, as well as calcium, as I've taken for years, and will be monitored with bone density tests, q year or 6 mos. if needed till done with arimidex, hopefully 5 years or less. I have none of the symptoms the rest of you mention. I do have low back discomfort, and arthritis in my thumbs, but have had it 6years or more. MarPat_353msn.com
Shortly after beginning Tamoxifen I also got "thumb arthritis". It got so bad that a specialist made xrays and recommened joint replacements in the thumbs. I had serious pain! However, within 3 months of stopping Arimidex,(my drug after Tamoxifen), my thumb joints are back to normal again!(Maybe minor pain during bouts of bad weather..) I also noticed Boniva increased my oesteoarthritis pain for several days after taking it. I have stopped Arimidex, stopped Boniva. I take my calcium and vitamins and Vit. D and a cholesterol lowering drug. My cholesterol count went sky high after Arimidex was added to my daily regimen. It is under control now--but not as great as use to be without the drug. I do think Arimidex is hard on the bones--I think it causes a lot of discomfort!! Pat, hope this helps some.
susanL

Midland, NC

#34 May 4, 2007
I didn't have chemo, but did have radiation. Is there anyone here who didn't have chemo and has neuropathy? Drs think my neuropathy is from radiation damage, but really, it's a theory. I have thought for some time that arimidex may have caused it. I took it for 4 years, tamoxifen for one. Am off it now and will mention my joint pain is gone. It was severe at first and then improved, but now it's gone.
SusanL
ESS survivor
Taxotere

Izmir, Turkey

#35 Jun 1, 2007
Latest advance about taxotere should be considered i think in every stages of breast cancer and lung cancer..This is a rememberence for me to you..By the way there are some alternative cancer treatments in http://www.canserious.com/special/alternative... link..May be you wanted to get an idea about natural treatment ways
lana

Godalming, UK

#36 Jun 7, 2007
Hi Linda, I have been on Armidex for three years and boy did I suffer and still am, am back on Tamoxifen as my life was unbearable with thigh cramps and pain in my feet, felt my bones in my feet were going to break. Evils of Armidex... Thank you for your comment.
LINDA wrote:
I've been taking Arimidex for almost three years. About 6 months ago I started getting severe (and I mean severe!) leg cramps at night (which seem to have replaced foot pain-that's gone all of a sudden). My oncologist prescribed Baclofen but I don't want to take it after reading about it in the PDR (it's prescribed for cerebral palsy--yikes!). Has anyone found a solution to the problem that doesn't involve drugs that may be worse than the problem? I don't want to stop the Arimidex before my 5 years are up. Any ideas?
lana

Godalming, UK

#37 Jun 7, 2007
I have been on Armidex for three years and boy did I suffer and still am, I am back on Tamoxifen as my life was unbearable with thigh cramps and pain in my fee, felt bones in my feet were going to break, Evils of Armidex
DENISE

Newport, MI

#38 Jun 28, 2007
Wow, Chemo, arimidex????
Same problem - 16 months OFF Arimidex and now on Tamoxifen. I quit Tamoxifen for a couple months to see if it changed...I didn't. Tamoxifen has increased hot flashes. I have knee, foot, hand, neck, shoulder pain and am developing arthritus.I HATE MILK, SO I EAT CHEESE, ALOT OF YOGURT NOW AND CHOCOLATE MILK. I ADD A NATURAL HERB TO MY YOGURT that's imported through a naturalist woman from Canada. So far so good. Discomfort with neck/shoulders causes sleep disturbances for me. I would like to know more about Femara.
My best friend who died recently from 2nd breast cancer + metasteses was on Tamoxifen for 5 years and Herceptinand other chemo drugs, she lost her battle in May 07. The problem here was in 98' when she had a tumor they removed it, she opted out of chemo-it wasn't pushed as much then either, then 5 years almost exactly she had 3 brain tumors, several lung nodules and it progressed after about 2-1/2 yrs - she fought hard, she had gamma knife, brain surgery, extensive/years of chemo. Best friends for 32 years - we had breast Cancer twice together, my mom lost her battle too 4.22.07 after 1.07.05 brain cancer, primary lung cancer, she was only 66 - I will miss them both - I have to keep trying.....it is very difficult, My doctor put me on Cymbalta for anxiety and depression last January 07, and it also helps alot with chronic pain. It has reduced mine probably about 35% or more, and helped manage the stress of losing my two favorite women. I stopped the Neurotin after starting Cymbalta, this works better, I had no side effects of neurotin, it got me through 8 months of 2006 to be able to work and walk more. Hang inthere ladies, WE ARE STILL HERE!
i speak the truth

United States

#39 Aug 2, 2007
DENISE wrote:
Wow, Chemo, arimidex????
Same problem - 16 months OFF Arimidex and now on Tamoxifen. I quit Tamoxifen for a couple months to see if it changed...I didn't. Tamoxifen has increased hot flashes. I have knee, foot, hand, neck, shoulder pain and am developing arthritus.I HATE MILK, SO I EAT CHEESE, ALOT OF YOGURT NOW AND CHOCOLATE MILK. I ADD A NATURAL HERB TO MY YOGURT that's imported through a naturalist woman from Canada. So far so good. Discomfort with neck/shoulders causes sleep disturbances for me. I would like to know more about Femara.
My best friend who died recently from 2nd breast cancer + metasteses was on Tamoxifen for 5 years and Herceptinand other chemo drugs, she lost her battle in May 07. The problem here was in 98' when she had a tumor they removed it, she opted out of chemo-it wasn't pushed as much then either, then 5 years almost exactly she had 3 brain tumors, several lung nodules and it progressed after about 2-1/2 yrs - she fought hard, she had gamma knife, brain surgery, extensive/years of chemo. Best friends for 32 years - we had breast Cancer twice together, my mom lost her battle too 4.22.07 after 1.07.05 brain cancer, primary lung cancer, she was only 66 - I will miss them both - I have to keep trying.....it is very difficult, My doctor put me on Cymbalta for anxiety and depression last January 07, and it also helps alot with chronic pain. It has reduced mine probably about 35% or more, and helped manage the stress of losing my two favorite women. I stopped the Neurotin after starting Cymbalta, this works better, I had no side effects of neurotin, it got me through 8 months of 2006 to be able to work and walk more. Hang inthere ladies, WE ARE STILL HERE!
More power to you! It is incredibly hard to go through something like this... I'm glad you are still going strong!
Susan

Eatontown, NJ

#41 Aug 19, 2007
I have been taking arimidex for a year. In the last 8 months I have had a preforated intestine and 3 months later had to have my gall bladder removed. My arthritis is worse and I have severe leg cramps at night. I have heard from friends and relatives that tomoxifen and femara also cause leg cramps. I am beginning to think that chemo, radiation and hormone therapy is taking their toll.This may be the price we have to pay to prevent recurrance.

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