Scientists Identify Potential New Target For Treating Triple Negative Breast Cancer
Scientists believe they may have found a new target for treating triple negative breast cancer - one of the more difficult breast cancers to treat successfully and for which there is no targeted therapy at present.
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Since: Dec 05
#1 Nov 17, 2010
You have patients not just with lung cancer, but with virtually all solid tumors who are potential candidates for EGFR targeted therapy.
There are advantages in having cells which you can define as Tarceva/Iressa sensitive or resistant and studying what exactly is different. Then there is testing to circumvent resistance. Then there is testing combinations.
Rather than only give Tarceva/Iressa to all NSCLC patients with EGFR positive mutation, it could be given selectively to patients with all types of cancer, if it otherwise indicated and if a functonal profiling assay is positive for it.
These scientists hoped that inhibiting these enzymes might also be a possible treatment for other cancers in which members of the EGFR family are active. In addition to EGFR, the family consists of Her2, Her3, Her4, and these are implicated in a number of cancers such as lung, colorectal, head and neck and pancreatic cancers.
The KRAS marker appears to have a stonger correlation to ovarian cancer. So they can test for the KRAS gene mutation for ovarian cancer. Tarceva or Erbitux for ovarian cancer? Maybe?
Until recently, cancer treatment was ususally based on the tumor's location, such as the lung or breast. Doctors are now starting to consider the biology of the tumor cell along with the site of the tumor when determining treatment. They are learning that the same proteins and pathways are involved in many types of cancer.
#2 Sep 23, 2013
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