Gene-Based Cancer Treatment Advances

Gene-Based Cancer Treatment Advances

There are 10 comments on the InteliHealth story from Feb 19, 2009, titled Gene-Based Cancer Treatment Advances. In it, InteliHealth reports that:

The day of cancer treatments tailored to people's genetic makeup is moving closer, the Associated Press reported February 16.

Join the discussion below, or Read more at InteliHealth.

Since: Dec 05

Irvington, NJ

#1 Feb 21, 2009
These microarray-based tests measure differences in gene sequence, gene expression or protein expression in biological samples. It is based on RNA microarry analysis and is an appropriate application of a genomic strategy to estimate prognosis. It scans thousands of genes to identify patterns of gene activity in individual tumors that indicate a patient is likely to suffer a recurrence of disease, and who may benefit from adjuvant chemotherapy.

If these genetic tests find a patient to be at high-risk, then a suitable platform can be used to utilize cell-based tests to better select a repertoire of available drugs to improve the efficacy of chemotherapy. None of the genetic tests can predict clinical responders. Further cell-based pre-tests can help see what treatments have the best opportunity of being successful.

Tests to identify molecular predisposing mechanisms still does not guarantee that a drug (or combinations of drugs) will be effective for an individual patient. Nor can they, for any patient or even large group of patients, discriminate the potential for clinical activity among different agents of the same class.

Microarray profiling tests, important in order to identify new therapeutic targets and thereby to develop useful drugs, still cannot work successfully in predicting treatment response for individual patients. Perhaps this is because they are performed on formalin-fixed, paraffin-embedded tissues or fresh-frozen tissue samples or unfrozen samples stored in RNA-preserving solution that were never actually exposed to the drugs whose activity they are trying to assess.

The cell-based "function" methodology is not hampered by the problems associated with gene or protein expression tests. That is because functional methodology measures the net effect of all processes within the cancer, acting with and against each other in real-time, and it tests living (fresh) cells actually exposed to drugs and drug combinations of interest.

The key to understanding the genome is understanding how cells work. The ultimate driver is a functional assay (is the cell being killed regardless of the mechanism) as opposed to a target assay (does the cell express a particular target that the drug is supposed to be attacking). While a target assay tells you whether or not to give one drug, a functional assay can find other compounds and combinations and can recommend them from the one assay.

The core of the functional assay is the cell, composed of hundreds of complex molecules that regulate the pathways necessary for vital cellular functions. If a targeted drug could perturb any one of these pathways, it is important to examine the effects of the drug within the context of the cell. Because genomics are far too limited in scope to encompass the vagaries and complexities of human cancer biology, these targeted therapies require the determination of cellular endpoints. Cell-based functional assays are being used for screening compounds for efficacy and biosafety.

Source: Cell Function Analysis
Gail Perry

Spring Hill, FL

#2 Feb 21, 2009
Hey folks, READ THE ARTICLE.

We AREN'T THERE YET for breast cancer. All the theory in the world won't change that.

By the way, GDP, that's a completely inadequate citation. It is not possible to confirm your elaborate claims based on that citation, which would not be acceptable in fifth grade or even in second grade for a science fair project.

What are you hiding? If nothing, then please provide the full citation so you won't look as if you're hiding something. If you don't provide full citation it could conceivably look as if you're just writing this stuff to puff yourself up or something.

Since: Dec 05

Irvington, NJ

#3 Feb 22, 2009
You can foam at the mouth all you want Gail. For someone who doesn't even know what paraphrasing means has lost all credibility.
Gail Perry

Spring Hill, FL

#4 Feb 22, 2009
GDP, back up your claims with real citations or look like a blowhard.

Since: Dec 05

Irvington, NJ

#5 Feb 28, 2009
Spoken like a true "flat earth" ideolog, Gail.

Since: Jun 07

Sanford, FL

#6 Feb 28, 2009
Nice little tiff going here. Hmmm I tend to agree with Gail. This is not poker where you must not let anybody know what is in your hand.
Gail Perry

Spring Hill, FL

#7 Mar 2, 2009
I made reference to the Flat Earth Society (as in illustration that not everything stateed is true) and I think GDP was just so flabbergasted to find out that not everything on the internet is actually true that he can't handle it.

I have no interest in having a tiff with GDP or anyone else, but he works very hard to sound like an expert -- and yet won't tell us what his expertise is, and won't provide verifiable cites. At the same time his information often flies in the face of the best advice people get from competent physicians.

To me that's a very bad combination of traits in an area where people deal with a life-threatening illness.

Since: Dec 05

Irvington, NJ

#8 Mar 2, 2009
Hundreds of thousands of cancer patients cannot wait for your "flat earth" society Gail.
Gail Perry

Spring Hill, FL

#9 Mar 3, 2009
Hundreds of thousands of cancer patients include me, GDP. What we don't need is overblown imaginings from people who have over-interpreted the research. Even when the truth isn't the ideal, the truth is what we need.

These tests are in the earliest developmental stages. If you have evidence otherwise, provide it. But don't expect an apology, because I've been asking you to back your claims up for at least a year.

I'm one of those hundreds of thousands, GDP. Right now there's no sign of a recurrence but it was breast cancer and it could happen at any time.

Stop bristling when people ask you questions and start answering them. Completely. With verifiable cites.(Not books, and not websites.)
Quintin
#10 Sep 23, 2013
I have ordered 2 times from this website PILLSMEDSHOP. COM . I called yesterday the customer care and asked for a discount as i was about to order twice the regular amount.

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